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Cat. No. | Product Name | Target | Signaling Pathways |
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T37691 |
Phosphatidic Acids (egg) (ammonium salt)
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Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis. It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple routes, including the glycerol-3 phosphate and dihydroxyacetone phosphate pathways, enzymatic conversion of phosphatidylcholine by phospholipase D, and acetylation of lysophosphatidic acid by lysoPA-acyltransferase, among others. It has roles in shaping cellular membranes, cellular ... | |||
T21729 |
(±)-Lisofylline
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Others | Others |
(±)-Lisofylline 是一种对映异构体特异性、烷基取代的甲基黄嘌呤,在下调白细胞活化方面具有特异性和有效的活性。它是一种抗炎剂。 | |||
T67073 | 1,2-Distearoyl-sn-glycero-3-phosphatidic acid (Na+ salt) | ||
1,2-Distearoyl-sn-glycero-3-phosphatidic acid (Na+ salt) 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T67073。 | |||
T21654 |
1-Oleoyl lysophosphatidic acid sodium
1-Oleoyl lysophosphatidic acid sodium salt |
LPA Receptor | GPCR/G Protein |
1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt 是 LPA1 和 LPA2 的内源性激动剂,可通过诱导 DNA 合成促进有丝分裂,参与正常和病理性情绪反应,如焦虑和抑郁。 | |||
T36907 |
1-Oleoyl Lysophosphatidic Acid
Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid |
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1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase.[1] Hydrolysis of the fatty acid at the sn-2 position by phospholipase A2 (PLA2) yields bioactive LPA. LPA binds to one of five differe... | |||
T36452 |
1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
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1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differe... | |||
T37283 |
1-Palmitoyl Lysophosphatidic Acid (sodium salt)
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1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, pipe... | |||
T33076 |
Lysophosphatidic acid
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Lysophosphatidic acid is a bioactive chemical. | |||
T83772 |
1-Linoleoyl Lysophosphatidic Acid sodium
1-Linoleoyl-2-hydroxy-sn-glycero-3-PA,LPA(18:2),PA(18:2(9Z,12Z)/0:0),1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate,18:2 Lyso PA,1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA,PA(18:2/0:0),1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate,1-Linoleoyl LPA |
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1-Linoleoyl LPA(1-亚油酰LPA)是LPA2受体的激动剂,属于一种含有亚油酸的甘油磷脂,在sn-1位置含亚油酸。它是小鼠和人体血浆中最丰富的LPA。1-Linoleoyl LPA在表达LPA2受体的Sf9细胞中选择性地增加细胞内钙水平(EC50约为10 nM),相较于表达LPA1和LPA3受体的Sf9细胞(EC50分别约为200和80 nM)。携带NCTC克隆2472肿瘤的小鼠中,1-linoleoyl LPA的血清水平增加。与患有初发进行性多发性硬化症的患者相比,复发缓解型多发性硬化症患者的血浆1-Linoleoyl LPA水平降低,且与神经功能缺损严重程度负相关。 | |||
T37282 |
1-Palmitoyl Lysophosphatidic Acid
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Antibacterial | Microbiology/Virology |
1-Palmitoyl Lysophosphatidic Acid 是 LPA 的类似物,通过结合 Ca2+ 和 Mg2+ 提高氨苄西林、哌拉西林和头孢他啶对各种铜绿假单胞菌菌株的作用。 | |||
T36768 |
1-Octadecyl Lysophosphatidic Acid
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1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA recepto... | |||
T77789 |
Oleoyl-L-alpha-lysophosphatidic acid sodium salt
LPA sodium salt |
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Oleoyl-L-alpha-lysophosphatidic acid sodium salt为必需的细胞膜生物合成代谢物,可通过与G蛋白偶联受体(GPCR)(即LPA受体)相互作用来介导信号传导,是LPA1和LPA2受体的内源性激动剂。 | |||
T83879 |
1-Arachidoyl Lysophosphatidic Acid sodium
1-Arachidoyl LPA,LPA(20:0),1-Eicosanoyl-Lysophosphatidic Acid |
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1-花生四烯酰基溶血磷脂酸(1-arachidoyl LPA)是溶血磷脂酸受体1(LPA1)的激动剂,并且是一种含有花生四烯酸的甘油磷脂,花生四烯酸位于sn-1位置。它能在主要表达LPA1而非LPA2-LPA6的人类肺成纤维细胞中诱导钙离子动员(EC50 = 3.6 µM)。在无细胞试验中,1-Arachidoyl LPA(2.5 µM)还能结合到过氧化物酶体增殖物激活受体γ(PPARγ)的配体结合域。人类尿液中也发现了该化合物。 | |||
T72322 |
R 59-022 hydrochloride
DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride |
5-HT Receptor; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Neuroscience |
R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂,可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生,并抑制嗜中性粒细胞中磷脂酸的产生。 | |||
T10005 |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate
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Others | Others |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate, a phosphatidic acid, is a human endogenous metabolite. | |||
T16709 |
R 59-022
Diacylglycerol kinase inhibitor I,DKGI-I |
Others | Others |
R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neu | |||
T37122 |
1,2-Dilinoleoyl-sn-glycerol
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1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (18:2) side chains attached at both the sn-1 and sn-2 positions. It has been found as a component of phosphatidic acid in rat liver mitochondria and in spinach chloroplast membranes. 1,2-Dilinoleoyl-sn-glycerol is upregulated in some pregnant women and has been used as a biomarker to predict later preeclampsia in early pregnancy. | |||
T76120 | Phospholipase D | ||
PhospholipaseD (PLD) ,即磷脂酶 D,是磷脂酶超家族的一种酶,广泛存在于细菌、酵母、植物、动物和病毒中,常用于生化研究。PhospholipaseD 可以催化甘油磷脂的磷酸二酯键水解,产生磷脂酸和可溶性胆碱。PhospholipaseD 参与了多种疾病相关过程,包括糖尿病、动脉粥样硬化形成、肥胖、肿瘤发生、免疫反应和神经内分泌功能。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T10005L |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium
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Endogenous Metabolite | Metabolism |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium 是一种人内源性代谢物,是一种磷酸酯。 | |||
T69446 |
Cochlioquinone A
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Cochlioquinone A is an inhibitor of diacylglycerol kinase (DGK) and diacylglycerol acyltransferase (DGAT). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma and has also been shown to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors. |