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Search Results for " l-leucine "

38

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T32811	L-Leucine-1-13C L-(1-13C)Leucine,(1-13C)Leucine	Endogenous Metabolite; mTOR	Metabolism; PI3K/Akt/mTOR signaling
	L-Leucine-1-13C (L-Leucine-13C)是一种 13C 标记的 L-Leucine，显著增强了 GLP-4 的亲和力。
T64400	N-Cbz-L-Leucine N-[(Phenylmethoxy)carbonyl]-L-leucine	Amino Acids and Derivatives	Metabolism
	N-Cbz-L-Leucine (N-[(Phenylmethoxy)carbonyl]-L-leucine) 是一种亮氨酸衍生物，是一种常用的氨基酸保护基基。
T7739	L-Leucyl-L-Leucine methyl ester hydrochloride Leu-Leu-ome hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) 是一种人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物，能够选择性消除具有细胞毒性潜能的淋巴细胞，也能够诱导溶酶体途径应激。
T1387	Acetylleucine N-Acetyl-DL-leucine,乙酰亮氨酸,N-acetyl-L-leucine	Amino Acids and Derivatives	Metabolism
	Acetylleucine (N-Acetyl-DL-leucine) 是一种口服具有活性的化合物，可用于研究急性前庭眩晕，小脑性共济失调和眼球震颤。
TP1264	Prolylleucine ((Benzyloxy)carbonyl)-L-prolyl-D-leucine	Others	Others
	Prolylleucine (((Benzyloxy)carbonyl)-L-prolyl-D-leucine) 是一种二肽，含有支链氨基酸，可以影响动物的昼夜节律和行为。
T8638	NPC 15199 FMOC-L-Leucine,Fmoc-L-亮氨酸	Others	Others
	NPC 15199 (FMOC-L-Leucine) 是选择性的PPARγ调节剂。它对 PPARγ 的激活效果比罗格列酮低，但二者最大效应相似。它能够改善正常、饮食诱导的葡萄糖不耐受和糖尿病 db/db 小鼠的胰岛素敏感性，一定程度上能够诱导脂肪生成。
T20445	L-Leucine-p-nitroanilide
	L-Leucine-p-nitroanilide is a substrate. It is used for the colorimetric determination of leucine aminopeptidase.
T33612	N-Carbomethoxy-L-leucine
	N-Carbomethoxy-L-leucine is a bioactive chemical.
T31907	Gamma-Methylleucine L-Neopentylglycine,gamma-Methyl-L-leucine,3-叔丁基-L-丙氨酸,2-Amino-3-tert-butylpropionic acid	Others	Others
	Gamma-Methylleucine (2-Amino-3-tert-butylpropionic acid) 是铜催化的不对称迈克尔反应的辅助剂。
T36879	L-Leucyl-L-Leucine methyl ester hydrobromide
	The lysosomotropic dipeptide LLME has selective toxicity for NK cells, CTL, and M phi without adverse effects on a variety of other lymphoid or nonlymphoid cell types. See also E-2080.
T37062	L-Leucine-7-amido-4-methylcoumarin hydrochloride
	L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase.1Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Izquierdo, M., Lin, D., O’Neill, S., et al.Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using rapidfire mass spectrometryS...
T11997	MELK-IN-1 Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L	MELK	PI3K/Akt/mTOR signaling
	MELK-IN-1 (MELK inhibitor 17)是一种母体胚胎亮氨酸拉链激酶的有效抑制剂，IC50=3 nM，Ki=0.39 nM。
T31948	Glutarylleucine Glutaryl-L-leucine
	Glutarylleucine is a bioactive chemical.
T20443	Tyrosylleucine Tyr-leu,L-Tyrosyl-L-leucine
	Tyrosylleucine is a dipeptide composed of tyrosine and leucine. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following
T34020	Phenylalanylleucine Phe-leu,L-Phenylalanyl-L-leucine
	Phenylalanylleucine is a bioactive chemical.
T33574	N-Acetylmelphalanylleucine N-Acetyl-melphalan-L-leucine
	N-Acetylmelphalanylleucine is a bioactive chemical.
T29839	Albutoin, (S)- L-Leucine-3-allyl-2-thiohydantoin
	Albutoin, (S)- can be used as a new thiohydantoin derivative for grand mal epilepsies.
T31711L	Ethyl L-leucinate Leucine ethyl ester
	Ethyl L-leucinate is a essential amino acid.
T64647	Boc-L-Leucine
	Boc-L-Leucine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64647，CAS号为 13139-15-6。
T131571	N-Benzoyl-L-Leucine
	N-Benzoyl-L-Leucine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131571。
T65805	L-Leucine benzyl ester p-toluenesulfonate salt
	L-Leucine benzyl ester p-toluenesulfonate salt 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65805，CAS号为 1738-77-8。
T65042	N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-leucine
	N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-leucine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65042，CAS号为 73401-65-7。
T8054	L-Leucyl-L-alanine Leucyl-alanine,L-Leucyl-L-alanine Hydrate,L-亮氨酸-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	L-Leucyl-L-alanine 是由 L-亮氨酸和 L-丙氨酸组成的简单二肽。
T5652	L(+)-Leucinol	Aminopeptidase	Metabolism
	L(+)-Leucinol 是一种有效的亮氨酸氨基肽酶抑制剂。
T41274	p-Fluoro-L-phenylalanine	Hydroxylase	Metabolism
	p-Fluoro-L-phenylalanine 是酪氨酸羟化酶的一种底物。它可以与大肠杆菌的 L-亮氨酸特异性受体结合，KD 为0.26 μM。
T36879L	H-Leu-Leu-OMe . HBr H-Leu-Leu-OMe . HBr (16689-14-8 Free base)	Others	Others
	H-Leu-Leu-OMe . HBr 是由人单核细胞或多形核白细胞产生的L-亮氨酸甲酯的二肽缩合产物。 H-Leu-Leu-OMe . HBr 诱导内溶酶体途径应激并选择性地消除具有细胞毒性潜力的淋巴细胞。
TQ0081	JPH203 KYT-0353	Others	Others
	JPH203 (KYT-0353) 是一种 L 型氨基酸转运蛋白 1 (LAT-1) 的抑制剂，具有有效性和特异性。JPH203 可以抑制细胞对亮氨酸的摄取，抑制细胞增殖、诱导细胞凋亡，具有抗炎和抗肿瘤活性。
T22043	BCATc Inhibitor 2	Others	Others
	BCATc Inhibitor 2 是选择性分支链氨基转移酶抑制剂，可用于神经退行性疾病的研究。能够抑制 rBCATc (IC50:0.2 μM)，hBCATc (IC50:0.8 μM)、 rBCATm (IC50:3.0 μM)。其中BCATc 也称为 BCAT1，存在于细胞质基质中的亚型。
T24906L	Tuna AI acetate	Angiotensin-converting Enzyme (ACE)	Metabolism
	Tuna AI acetate 是一种源自金枪鱼肌肉的非竞争性血管紧张素转换酶 (ACE) 抑制剂。
T76108	Leucine dehydrogenase
	Leucine dehydrogenase 能够从球形芽孢杆菌中纯化得到。Leucine dehydrogenase 催化L-亮氨酸、L-缬氨酸、L-异亮氨酸、L-去甲缬氨酸、左旋α-氨基丁酸酯和L-去甲亮氨酸的氧化脱氨，以及它们的酮类似物的还原胺化。
T35727	4-methyl-2-Oxovalerate (sodium salt)
	4-methyl-2-Oxovalerate is an immediate precursor and metabolite of L-leucine. It is a precursor leading to the synthesis of 2-methylpropyl glucosinolate, via L-leucine, in plants. 4-methyl-2-Oxovalerate is one of several plasma metabolites found to differ significantly between type 2 diabetes and control subjects.
T32404	KMH-233 KMH233
	KMH-233 is a potent selective LAT1 inhibitor 1 that inhibits the uptake of LAT1 substrate, L-leucine, and cell growth. Even at low concentrations (25 μM), it significantly enhanced the efficacy of betastatin and cisplatin.
T82191	H-Leu-Leu-Ala-OH
	H-Leu-Leu-Ala-OH，一种三肽，由两个L-亮氨酸单元通过肽键与一个L-丙氨酸单元连接，具备抗氧化活性。
T10939	D,L-Cystathionine dihydrochloride	Others	Others
	D,L-Cystathionine dihydrochloride is an intermediate in the synthesis of cysteine, which acts from the isotype of cysteine-β-synthase (CBS) produced by leucine and serine. Derived from cysteine. DL-cysteine contains a cysteine (βC-S) carbon-sulfur bond.
T37640	trans-2-Hexadecenoyl-L-carnitine
	trans-2-Hexadecenoyl-L-carnitine is an endogenous metabolite in urine[1]. [1]. Pengxiang She, et al. Leucine and protein metabolism in obese Zucker rats. PLoS One. 2013;8(3):e59443.
T36098	Isovaleryl-L-carnitine (chloride)
	Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated wit...
T83853	L-K6L9 TFA
	L-K6L9 是由 L-亮氨酸和 L-赖氨酸的L-异构体组成的溶细胞肽。对LNCaP-CL1 雄激素独立型和22Rv1以及LNCaP雄激素依赖型人类前列腺癌细胞具有细胞毒性（LC50分别为4、4和6 µM），同时也对非癌性NIH3T3小鼠成纤维细胞和OL人类包皮成纤维细胞具有细胞毒性（LC50分别为7和5 µM）。在100 µM的浓度下，引起分离的人类红细胞溶血。
T36650	Ansatrienin B
	Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul...

化合物

L-Leucine-1-13C

Cat.No: T32811

Synonym: L-(1-13C)Leucine,(1-13C)Leucine

Target: Endogenous Metabolite, mTOR

N-Cbz-L-Leucine

Cat.No: T64400

Synonym: N-[(Phenylmethoxy)carbonyl]-L-leucine

Target: Amino Acids and Derivatives

L-Leucyl-L-Leucine methyl ester hydrochloride

Cat.No: T7739

Synonym: Leu-Leu-ome hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T1387

Synonym: N-Acetyl-DL-leucine,乙酰亮氨酸,N-acetyl-L-leucine

Target: Amino Acids and Derivatives

Cat.No: TP1264

Synonym: ((Benzyloxy)carbonyl)-L-prolyl-D-leucine

Target: Others

Cat.No: T8638

Synonym: FMOC-L-Leucine,Fmoc-L-亮氨酸

Target: Others

L-Leucine-p-nitroanilide

Cat.No: T20445

N-Carbomethoxy-L-leucine

Cat.No: T33612

Gamma-Methylleucine

Cat.No: T31907

Synonym: L-Neopentylglycine,gamma-Methyl-L-leucine,3-叔丁基-L-丙氨酸,2-Amino-3-tert-butylpropionic acid

Target: Others

L-Leucyl-L-Leucine methyl ester hydrobromide

Cat.No: T36879

L-Leucine-7-amido-4-methylcoumarin hydrochloride

Cat.No: T37062

Cat.No: T11997

Synonym: Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L

Target: MELK

Glutarylleucine

Cat.No: T31948

Synonym: Glutaryl-L-leucine

Cat.No: T20443

Synonym: Tyr-leu,L-Tyrosyl-L-leucine

Phenylalanylleucine

Cat.No: T34020

Synonym: Phe-leu,L-Phenylalanyl-L-leucine

N-Acetylmelphalanylleucine

Cat.No: T33574

Synonym: N-Acetyl-melphalan-L-leucine

Cat.No: T29839

Synonym: L-Leucine-3-allyl-2-thiohydantoin

Ethyl L-leucinate

Cat.No: T31711L

Synonym: Leucine ethyl ester

Cat.No: T64647

N-Benzoyl-L-Leucine

Cat.No: T131571

L-Leucine benzyl ester p-toluenesulfonate salt

Cat.No: T65805

N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-leucine

Cat.No: T65042

L-Leucyl-L-alanine

Cat.No: T8054

Synonym: Leucyl-alanine,L-Leucyl-L-alanine Hydrate,L-亮氨酸-L-丙氨酸

Target: Others, Endogenous Metabolite

Cat.No: T5652

Target: Aminopeptidase

p-Fluoro-L-phenylalanine

Cat.No: T41274

Target: Hydroxylase

H-Leu-Leu-OMe . HBr

Cat.No: T36879L

Synonym: H-Leu-Leu-OMe . HBr (16689-14-8 Free base)

Target: Others

Cat.No: TQ0081

Synonym: KYT-0353

Target: Others

BCATc Inhibitor 2

Cat.No: T22043

Target: Others

Tuna AI acetate

Cat.No: T24906L

Target: Angiotensin-converting Enzyme (ACE)

Leucine dehydrogenase

Cat.No: T76108

4-methyl-2-Oxovalerate (sodium salt)

Cat.No: T35727

Cat.No: T32404

Synonym: KMH233

H-Leu-Leu-Ala-OH

Cat.No: T82191

D,L-Cystathionine dihydrochloride

Cat.No: T10939

Target: Others

trans-2-Hexadecenoyl-L-carnitine

Cat.No: T37640

Isovaleryl-L-carnitine (chloride)

Cat.No: T36098

Cat.No: T83853

Cat.No: T36650

Cat. No.	Product Name	Target	Signaling Pathways
T3O2749	L-Leucine (S)-Leucine,Leu,L-亮氨酸,亮氨酸	mTOR	PI3K/Akt/mTOR signaling
	L-Leucine ((S)-Leucine) 是必需的支链氨基酸，能够激活 mTOR 信号通路。
T4086	Glycyl-L-leucine 甘氨酰-L-亮氨酸,Gly-Leu	Others	Others
	Glycyl-L-leucine (Gly-Leu) 是一种可用作糖基亮氨酸二肽酶底物的二肽。
T4798	N-Acetyl-L-leucine	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-leucine 是内源性代谢产物的一种。
T8373	6-Diazo-5-oxo-L-nor-Leucine DON,L-6-Diazo-5-oxonorleucine,6-重氮-5-氧代-L-正亮氨酸,Diazooxonorleucine	Influenza Virus; Glutaminase; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome
	6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) 是一种谷氨酰胺拮抗剂，具有抗菌、抗病毒和抗癌作用，其Ki 值为 6 μM。它能降低肿瘤细胞的自我更新能力和转移能力，在体外表现出遗传毒性。
TMA2613	Cyclo(Pro-Leu) Cyclo-L-leu-L-pro,Cyclo-L-prolyl-L-leucine,Cyclo(leucyloprolyl)	Others	Others
	Cyclo(Pro-Leu) (Cyclo-L-prolyl-L-leucine) 是一种源自海洋的天然产物，具有盐水虾的杀伤力。
T9299	D-Leucine D-亮氨酸,(R)-Leucine	Endogenous Metabolite	Metabolism
	D-Leucine ((R)-Leucine) 具有抗癫痫特性，活性比L-leucine，能够有效终止癫痫发作。在体外，它能够抑制长期点位，但基底突触传递无影响。
T4765	L-Norleucine (S)-Norleucine,alpha-Aminocaproic acid,(S)-2-Aminohexanoic acid,L-2-氨基己酸	Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology
	L-Norleucine ((S)-Norleucine) 是亮氨酸的异构体，特异性影响骨骼肌中的蛋白质合成，具有抗病毒活性。
T0063	L-Isoleucine 异亮氨酸,isoleucine,Ile,L-异亮氨酸	Amino Acids and Derivatives; Endogenous Metabolite	Metabolism
	L-Isoleucine (Ile) 是一种非极性疏水性氨基酸。它是必需氨基酸。
T19384	Isovalerylcarnitine	Apoptosis; Cysteine Protease	Apoptosis; Proteases/Proteasome
	Isovalerylcarnitine (3-methylbutyrylcarnitine) 是 L-亮氨酸分解代谢和异戊酸的积累产生的小分子化合物，也是一种具有选择性和有效性的钙蛋白酶 (calpain) 激活剂，可促使细胞凋亡，与异戊酸血症有关，可作为异戊酸血症的标志。
TN2408	Evofolin B	Cannabinoid Receptor	GPCR/G Protein
	Evofolin B 是从Zanthoxylum ailanthoides 的茎皮中分离出来的天然化合物。Evofolin B 对人类中性粒细胞对甲酰-L-蛋氨酸-L-亮氨酸-L-苯丙氨酸/cytochalasin B（fMLP/CB）产生的超氧阴离子有抑制作用。

天然产物

Cat.No: T3O2749

Synonym: (S)-Leucine,Leu,L-亮氨酸,亮氨酸

Target: mTOR

Glycyl-L-leucine

Cat.No: T4086

Synonym: 甘氨酰-L-亮氨酸,Gly-Leu

Target: Others

N-Acetyl-L-leucine

Cat.No: T4798

Target: Others, Endogenous Metabolite

6-Diazo-5-oxo-L-nor-Leucine

Cat.No: T8373

Synonym: DON,L-6-Diazo-5-oxonorleucine,6-重氮-5-氧代-L-正亮氨酸,Diazooxonorleucine

Target: Influenza Virus, Glutaminase, Antibacterial, Antibiotic

Cat.No: TMA2613

Synonym: Cyclo-L-leu-L-pro,Cyclo-L-prolyl-L-leucine,Cyclo(leucyloprolyl)

Target: Others

Cat.No: T9299

Synonym: D-亮氨酸,(R)-Leucine

Target: Endogenous Metabolite

Cat.No: T4765

Synonym: (S)-Norleucine,alpha-Aminocaproic acid,(S)-2-Aminohexanoic acid,L-2-氨基己酸

Target: Influenza Virus, Endogenous Metabolite

Cat.No: T0063

Synonym: 异亮氨酸,isoleucine,Ile,L-异亮氨酸

Target: Amino Acids and Derivatives, Endogenous Metabolite

Isovalerylcarnitine

Cat.No: T19384

Target: Apoptosis, Cysteine Protease

Cat.No: TN2408

Target: Cannabinoid Receptor

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