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Targets Recommended: HBV HIV Protease Reverse Transcriptase

9

抑制剂 & 化合物

7

天然产物

13

重组蛋白

1

同位素标记化合物

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Cat. No. Product Name Target Signaling Pathways
T1649 Tenofovir

替诺福韦,泰诺福韦,PMPA,TDF,GS 1278

HBV; HIV Protease; Reverse Transcriptase Microbiology/Virology; Proteases/Proteasome
Tenofovir (GS 1278) 是一种核苷酸逆转录酶抑制剂,可研究 HIV 和慢性乙型肝炎。
T1065 Baclofen

巴氯芬,Lioresal

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Baclofen (Lioresal) 是 γ-氨基丁酸 (GABA) 的亲脂性衍生物,是可口服的选择性代谢型 GABA-B 受体激动剂,具有高血脑屏障渗透率,用于治疗因脊髓损伤和多发性硬化引起的痉挛。
T8630 Baclofen hydrochloride

4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) 是一种 GAMMA-AMINOBUTYRIC ACID 衍生物,是一种特异性 GABA-B 受体激动剂。它用于治疗肌肉痉挛,尤其是由于脊髓损伤引起的肌肉痉挛。其治疗效果来自于脊髓和脊髓上部位的作用,通常是减少兴奋性传递。
T24883 Tingenin B

22-Hydroxytingenone

Others Others
Tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Tingenin b was cytotoxic against MCF-7s (IC50: 2.38 μM for 48 h) by inducing apoptosis. Endoplasmic reticulum stress was also found to be
T17306 (R)-Baclofen hydrochloride

Arbaclofen hydrochloride,(R)-巴氯芬盐酸盐

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to spinal cord damage. It acts at spinal and supraspinal sites, generally reduces excitatory tra
T36608 (±)8-HEPE

Others Others
(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 8(S)-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.[1][2] Reference:[1]. Shing, T.K.M., Gibson, K.H., Wiley, J.R., et al. First total synthesis of a barnacle hatching factor 8(R)-hydroxy-eicosa-5(Z),9(E),11(Z)-pentaenoic acid. Tetrahedron Letters 35, 1067-1070 (1994).[2]. Hill, E...
T28510 REDX05358

REDX 05358,REDX-05358

Others Others
REDX05358 is a highly selective and potent pan RAF inhibitor with a potential therapeutic for BRAF and RAS mutant tumors. REDX05358 has improved therapeutic potential and predicted safety profile. REDX05358 demonstrates subnanomolar binding affinity for B
T63552 FtsZ-IN-1

Others Others
FtsZ-IN-1 是有效的、具有喹啉环的 FtsZ 抑制剂,对革兰氏阳性菌具有较强的抑菌效果 (MIC: 0.5-8 μg/mL)。FtsZ-IN-1 能够提高 FtsZ 聚合作用,明显促进枯草芽孢杆菌 (B. subtilis) 的细胞伸长。FtsZ-IN-1 拥有低溶血毒性和低诱导耐药倾向,表现出抗耐药性细菌效果。
T83820 TNP-GTP sodium

TNP-Guanosine 5'-triphosphate

TNP-GTP是一种荧光衍生物,源自蛋白质合成与糖异生的能量底物鸟苷三磷酸(GTP)。其在水中激发波长为410 nm时,发射最大波长为552 nm,而在40%和80%的N,N-二甲基甲酰胺中,其荧光强度增加,发射波长分别向544 nm和532 nm移动,这是因为N,N-二甲基甲酰胺的极性比水小。TNP-GTP是谷氨酸脱氢酶的抑制剂(Ki = 2.7 μM)。当与谷氨酸脱氢酶结合时,TNP-GTP的荧光强度增加,且发射波长从552 nm变为545 nm,此效果可以通过加入GTP来阻断。TNP-GTP还是嘌呤P2X2和P2X2/3受体的拮抗剂(IC50s分别为0.4和1.2 nM)。它还选择性抑制大鼠可溶性鸟苷酸环化酶(sGC; Ki = 11 nM)高于牛肝谷氨酸脱氢酶(GDH; Ki = 2.7 µM)以及钙调素依赖的B. pertussis腺苷酸环化酶(AC)毒素(Kis在存在锰或镁时分别为20和320 µM)。

化合物

Tenofovir
Cat.No: T1649
Synonym: 替诺福韦,泰诺福韦,PMPA,TDF,GS 1278
Target: HBV, HIV Protease, Reverse Transcriptase
Baclofen
Cat.No: T1065
Synonym: 巴氯芬,Lioresal
Target: GABA Receptor
Baclofen hydrochloride
Cat.No: T8630
Synonym: 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride
Target: GABA Receptor
Tingenin B
Cat.No: T24883
Synonym: 22-Hydroxytingenone
Target: Others
(R)-Baclofen hydrochloride
Cat.No: T17306
Synonym: Arbaclofen hydrochloride,(R)-巴氯芬盐酸盐
Target: GABA Receptor
(±)8-HEPE
Cat.No: T36608
Synonym:
Target: Others
REDX05358
Cat.No: T28510
Synonym: REDX 05358,REDX-05358
Target: Others
FtsZ-IN-1
Cat.No: T63552
Synonym:
Target: Others
TNP-GTP sodium
Cat.No: T83820
Synonym: TNP-Guanosine 5'-triphosphate
Target:
Cat. No. Product Name Target Signaling Pathways
T6S2246 Alisol B 23-acetate

Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯

Others Others
Alisol B 23-acetate (Alisol B Acetate) 是三萜类化合物,能够激活法尼醇受体,诱导受损的肝脏再生。
T3717 Hinokitiol

4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇

DNA Methyltransferase; Virus Protease; Estrogen/progestogen Receptor; Nrf2 Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
Hinokitiol (4-Isopropyltropolone) 是从日本扁柏中分离到的一种挥发油成分,可抑制紫外线 B 诱导的角质形成细胞凋亡,可调节雌激素受体信号传导并抑制人乳腺癌细胞的增殖。它具有抗感染、抗氧化及抗肿瘤等活性。
T6S1917 Schisandrol B

Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

P450; Reactive Oxygen Species; Autophagy Autophagy; Immunology/Inflammation; Metabolism; NF-κB
Schisandrol B (Besigomsin) 是华中五味子的主要活性成分,具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生,也抑制 P-糖蛋白和CYP3A 的活性。
TN2063 Physalin B

NSC-287088

Apoptosis; NF-κB; Akt; PI3K; Nrf2; NOD Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
Physalin B 是茄科植物的主要活性化合物之一,具有广泛的生物活性,可用于治疗炎症湿疹和疱疹等疾病。Physalin B 通过激活 PI3K/Akt 通路抑制 NF-κB 和 NLRP3,从而改善脂多糖诱导的急性肺损伤造成的炎症反应。Physalin B 通过激活 Nrf2 通路抑制 PDGF-BB 诱导的 VSMC 增殖、迁移和表型转化。Physalin B 通过抑制 LAP2α-HDAC1 介导的胶质瘤相关癌基因 1 的去乙酰化和肝星状细胞活化来发挥抗肿瘤活性。
T5S2343 Acetylshikonin

乙酰紫草素,Acetyl shikonin

Others; P450; AChE Metabolism; Neuroscience; Others
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN6458 Acetylshikonin

Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
T81169 Shishijimicin B

Shishijimicin B为活性的烯二炔类化合物,具有强烈的细胞毒性,IC50值介于2.0 - 3.3 nM。此化合物表现出抗肿瘤活性,常用于癌症研究中。作为点击化学试剂,Shishijimicin B内含Alkyne基团,能通过含Azide基团的分子在铜催化下发生(CuAAc)反应。

天然产物

Alisol B 23-acetate
Cat.No: T6S2246
Synonym: Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯
Target: Others
Hinokitiol
Cat.No: T3717
Synonym: 4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇
Target: DNA Methyltransferase, Virus Protease, Estrogen/progestogen Receptor, Nrf2
Schisandrol B
Cat.No: T6S1917
Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B
Target: P450, Reactive Oxygen Species, Autophagy
Physalin B
Cat.No: TN2063
Synonym: NSC-287088
Target: Apoptosis, NF-κB, Akt, PI3K, Nrf2, NOD
Acetylshikonin
Cat.No: T5S2343
Synonym: 乙酰紫草素,Acetyl shikonin
Target: Others, P450, AChE
Acetylshikonin
Cat.No: TN6458
Synonym:
Target:
Shishijimicin B
Cat.No: T81169
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPJ-01241 DTD1 Protein, Human, Recombinant (His)

DUE-B,D-tyrosyl-tRNA(Tyr) deacylase 1,DNA-...

Human HEK293 Cells
D-tyrosyl-tRNA(Tyr) deacylase 1(DTD1) belongs to the DTD family, and expressed in many adult and fetal tissues such as testis, ovary, spleen in adult and fetal brain. It is a nucleus and cytoplasm located protein, and is preferentially phosphorylated in cells arrested early in S phase. DTD1 is an ATPase involved in DNA replication, it may facilitate loading of CDC45 onto pre-replication complexes. The protein may hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defens...
TMPJ-00797 LDHB Protein, Human, Recombinant (His)

LDH-B,Renal Carcinoma Antigen NY-REN-46,LDH-H,LDH H...

Human E. coli
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LDH-B is an oxidoreductase that catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. It converts pyruvate to lactate when oxygen is absent or in short supply and it performs the reverse reaction during the Cori cycle in the liver....
TMPK-00234 CD84 Protein, Human, Recombinant (His & Avi)

CD84,DKFZp781E2378,Hly9-beta,Hly9-β,CD84 molecule,S...

Human HEK293 Cells
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5 B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells.
TMPJ-00202 CD157 Protein, Human, Recombinant (hFc)

Cyclic ADP-ribose hydrolase 2,cADPr hydrolase 2,ADP...

Human HEK293 Cells
The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth. CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities followed with CD38. It plays a role in rheumatoid arthritis (RA) due to its enhanced expression in RA-derive...
TMPJ-00968 NAMPT Protein, Human, Recombinant (His)

PBEF,PBEF1,Nicotinamide phosphorib

Human E. coli
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are ...
TMPY-02191 BLNK Protein, Human, Recombinant (His)

BLNK-S,bca,SLP-65,B-cell linker,L...

Human HEK293 Cells
B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65 and BLNK, is a cytoplasm and cell membrane protein which contains oneSH2 domain. BLNK is expressed in B-cell lineage and fibroblast cell lines. Highest levels of expression is in the spleen, with lower levels in the liver, kidney, pancreas, small inte...
TMPJ-00352 CD98 Protein, Human, Recombinant (mFc)

Lymphocyte activation antigen 4F2 large subunit,4F2...

Human HEK293 Cells
CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis,...
TMPY-03985 Adenosine Deaminase Protein, Human, Recombinant (His)

ADA1,adenosine deaminase,ADA

Human Baculovirus Insect Cells
Adenosine Desaminase (ADA) deficiency, is a purine metabolic disorder that cause severe combined immunodeficiency (SCID) due to the accumulation of toxic metabolites that primarily affects development, differentiation and function of T and B lymphocytes. Adenosine deaminase is a polymorphic enzyme that has an important role in immune functions and in the regulation of intracellular and extracellular concentrations of adenosine and adenosine receptor activity. ADA activity might be considered as...
TMPY-02252 LAMTOR2 Protein, Human, Recombinant (His)

Ragulator2,p14,MAPBPIP,MAPKSP1AP,RP11-336K24.9,HSPC...

Human E. coli
Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, Roadblock domain-containing protein 3, LAMTOR2, MAPBPIP, and ROBLD3, is a protein which belongs to the GAMAD family. LAMTOR2 / ROBLD3 is a regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factor...
TMPY-01953 CALML5 Protein, Human, Recombinant (His & GST)

calmodulin like 5,CLSP

Human E. coli
Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains fourEF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily a...
TMPK-01413 H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)

H-2K,OVA,MHC,H2-K1

Mouse HEK293 Cells
Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of the frst OVA epitopes to be characterised, it has an amino acid sequence SIINFEKL, which is recognised by cytotoxic T lymphocytes. SIINFEKL forms fbrillar assemblies similar to other peptide hydrogels. Te immunoactive properties of this peptide can therefore be related to its se...
TMPK-01412 HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)

SARS-CoV-2 epitope,MHC

Human HEK293 Cells
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
TMPK-01416 HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated

MHC,SARS-CoV-2 epitope

Human HEK293 Cells
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.

重组蛋白

DTD1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01241
Species: Human
Expression System: HEK293 Cells
LDHB Protein, Human, Recombinant (His)
Cat.No: TMPJ-00797
Species: Human
Expression System: E. coli
CD84 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00234
Species: Human
Expression System: HEK293 Cells
CD157 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00202
Species: Human
Expression System: HEK293 Cells
NAMPT Protein, Human, Recombinant (His)
Cat.No: TMPJ-00968
Species: Human
Expression System: E. coli
BLNK Protein, Human, Recombinant (His)
Cat.No: TMPY-02191
Species: Human
Expression System: HEK293 Cells
CD98 Protein, Human, Recombinant (mFc)
Cat.No: TMPJ-00352
Species: Human
Expression System: HEK293 Cells
Adenosine Deaminase Protein, Human, Recombinant (His)
Cat.No: TMPY-03985
Species: Human
Expression System: Baculovirus Insect Cells
LAMTOR2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02252
Species: Human
Expression System: E. coli
CALML5 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-01953
Species: Human
Expression System: E. coli
H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)
Cat.No: TMPK-01413
Species: Mouse
Expression System: HEK293 Cells
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01412
Species: Human
Expression System: HEK293 Cells
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01416
Species: Human
Expression System: HEK293 Cells
Cat. No. Product Name Target Signaling Pathways
TMIJ-0314 Baclofen-d4

Baclofen-d4 是 Baclofen 的氘代化合物。Baclofen 的 CAS 号为 1134-47-0。Baclofen 是 γ-氨基丁酸 (GABA) 的亲脂性衍生物,是可口服的选择性代谢型 GABA-B 受体激动剂,具有高血脑屏障渗透率,用于治疗因脊髓损伤和多发性硬化引起的痉挛。

同位素标记化合物

Baclofen-d4
Cat.No: TMIJ-0314
Synonym:
Target:
TargetMol Loading
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