C-24

YLF-466D (C24) 是一种新型 AMPK 激活剂，可抑制血小板聚集。

Tetracosanoyl-sulfatide is an endogenous sulfated glycolipid, which are also known as sulfatides . Tetracosanoyl-sulfatide is the major sulfatide in mature myelin in the central and peripheral nervous systems. Levels of Tetracosanoyl-sulfatide are elevated in plasma derived from patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency, leading to sulfatide accumulation. Unlike C24:1 3'-sulfo galactosylceramide, it does not induce an immune response in mouse splenocytes in vitro.

C24 dihydro 1-Deoxyceramide (m18:0 24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24 dihydro 1-Deoxyceramide (m18:0 24:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found in mouse brain, spinal cord, and sciatic nerve at one, three, and six months of age.4 |1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine. J. Lipid Res. 57(7), 1194-1203 (2016).|2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J. Lipid Res. 58(1), 60-71 (2017).|3. Alecu, I., Tedeschi, A., Behler, N., et al. Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction. J. Lipid. Res. 58(1), 42-59 (2017).|4. Schwartz, N.U., Mileva, I., Gurevich, M., et al. Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. Prostaglandins Other Lipid Mediat. 141, 40-48 (2019).

C24:1 3'-sulfo Galactosylceramide (d18:1 24:1(15Z))是成熟髓鞘中主要的硫酸盐类化合物。C24:1 3'-sulfo Galactosylceramide (d18:1 24:1(15Z)) 在大鼠小脑中发现活跃的髓发生鞘化反应时积累率高于C24 3'-sulfo 半乳糖甘油酰胺。C24:1 3'-sulfo Galactosylceramide (d18:1 24:1(15Z))与C 型凝集素和免疫球蛋白样受体相互作用使对LMIR5的亲和力高。C24:1 3'-sulfo Galactosylceramide (d18:1 24:1(15Z))诱导嗜碱细胞产生MCP-1，可通过增加LMIR5激活NFAT，但不能诱导肥大细胞 。C24:1 3'-sulfo Galactosylceramide (d18:1 24:1(15Z))在体外与CD1d 结合，并增加游离小鼠脾细胞的增殖。

C24 Phytosphingosine (t18:0/24:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C24 Phytosphingosine (t18:0/24:0) is composed of a phytosphingosine backbone amine-linked to a C24 fatty acid chain. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro. In a stratum corneum model of healthy skin, the incorporation of long-chain-containing phytoceramides, such as C24 phytosphingosine (t18:0/24:0), increases permeability of the membrane in comparison with incorporation of dihydroceramides.

Lipid C24，一种阳离子可电离脂质，适用于脂质纳米颗粒(LNP)合成，主要应用于核酸递送研究。

C24-Ceramide，一种参与构成脂质膜的鞘磷脂，具有诱导膜特性时间依赖性变化及促进膜重组的功能。

C24:1 1-Deoxyceramide (m18:1 24:1(15Z)) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 1246298-58-7。

C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0 24:0) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 164989-36-0。

C24:1 dihydro 1-Deoxyceramide (m18:0 24:1) 是一种脂质分子，可用于生命科学相关研究，其 CAS 号为 1246298-60-1。

C24 Ceramide-d7 是 C24 Ceramide 的氘代化合物。

C24:1 Ceramide-d7 是 C24:1 Ceramide 的氘代化合物。

Nervonic Acid Methyl Ester (Standard) is the standard substance of Nervonic Acid Methyl Ester, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nervonic Acid Methyl Ester is a natural product.

AC-24,055 is a synthetic insect feeding repellent.

NSC-2488 is a novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.

Ro 3306 是一种 CDK1 抑制剂，可以抑制 CDK1、CDK1/cyclin B1 和 CDK2/cyclin E (Ki=20/35/340 nM)，具有选择性和 ATP 竞争性。Ro-3306 具有抗肿瘤活性，可以抑制细胞周期阻滞，诱导细胞凋亡。

Osemozotan HCl (Osemozotan hydrochloride) 是一种新型且具有选择性的 5-HT1A 受体激动剂，可降低甲基苯丙胺诱导的内侧前额叶皮层和纹状体中的c-Fos表达。Osemozotan HCl 可用于研究机械异常性疼痛和抑郁症。

Econazole nitrate (NSC-243115) 是一种有抗菌活性的咪唑类抗真菌药物。

Disodium monofluorophosphate (NSC248) 是丙酮酸激酶和碱性磷酸酶的竞争性抑制剂，它也不可逆地抑制磷酸化酶磷酸酶。

Carboplatin (JM-8) 是一种顺铂衍生物，一种 DNA 合成抑制剂。Carboplatin 能够与 DNA 结合，抑制复制和转录并诱导细胞死亡。Carboplatin 具有抗肿瘤活性。

Methyl levulinate是一种可以通过生物质衍生的绿色试剂，广泛应用于生物化学实验和药物合成研究。

CZC24832 是一种PI3Kγ选择性抑制剂，其 IC50=27 nM，Kdapp=19 nM。

C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squamous carcinoma cells in vitro.[4] C24 dihydro Ceramide levels are also increased in INS-1 β-cells incubated with glucose and palmitate.[5]

Zoxazolamine (NSC-24995) 是排尿酸和肌肉松弛剂，被广泛用于药物测试，可作为啮齿动物细胞色素 P-450 活性变化的方便指标。