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Thalidomide-5,6-F is a cereblon ligand derived from Thalidomide that is utilized for the recruitment of CRBN protein. It can be conjugated to a protein ligand through a linker, thus enabling the formation of PROTACs, a class of molecules with targeted protein degradation capabilities.
Thalidomide-5,6-F is a cereblon ligand derived from Thalidomide that is utilized for the recruitment of CRBN protein. It can be conjugated to a protein ligand through a linker, thus enabling the formation of PROTACs, a class of molecules with targeted protein degradation capabilities.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 mg | ¥ 154 | 5日内发货 |
产品描述 | Thalidomide-5,6-F is a cereblon ligand derived from Thalidomide that is utilized for the recruitment of CRBN protein. It can be conjugated to a protein ligand through a linker, thus enabling the formation of PROTACs, a class of molecules with targeted protein degradation capabilities. |
体外活性 | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
分子量 | 294.21 |
分子式 | C13H8F2N2O4 |
CAS No. | 1496997-41-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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