Powder: -20°C for 3 years | In solvent: -80°C for 1 year
sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体,能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响,同时具有良好的耐受性和安全性,因此能够用于阿尔茨海默病和痴呆症的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 326 | 现货 | ||
1 g | ¥ 395 | 现货 | ||
5 g | ¥ 637 | 5日内发货 | ||
10 g | ¥ 822 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 395 | 现货 |
产品描述 | sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia. sn-Glycero-3-phosphocholine rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer's disease. An Italian multicentre clinical trial on 2, 044 patients suffering from recent stroke were supplied Glycerylphosphorylcholine in doses of 1, 000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2]. |
别名 | Choline Alfoscerate, 甘磷酸胆碱, Glycerophosphocholine, Glycerophosphorylcholine, Alpha-GPC, Choline glycerophosphate, L-α-GPC |
分子量 | 257.22 |
分子式 | C8H20NO6P |
CAS No. | 28319-77-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.8877 mL | 19.4386 mL | 38.8772 mL | 97.1931 mL |
5 mM | 0.7775 mL | 3.8877 mL | 7.7754 mL | 19.4386 mL | |
10 mM | 0.3888 mL | 1.9439 mL | 3.8877 mL | 9.7193 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
sn-Glycero-3-phosphocholine 28319-77-9 Metabolism Neuroscience Endogenous Metabolite AChE Choline Alfoscerate 甘磷酸胆碱 Glycerophosphocholine Inhibitor L-alpha-GPC Glycerophosphorylcholine Alpha-GPC inhibit Choline glycerophosphate a-GPC snGlycero3phosphocholine Cholinesterase (ChE) L-α-GPC sn Glycero 3 phosphocholine α-GPC L-a-GPC inhibitor