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Cefpodoxime (free acid)

Name: Cefpodoxime (free acid)
Brand: TargetMol
SKU: T4998L
Price: 187 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.94%

货号 T4998LCas号 80210-62-4

别名 头孢泊肟

Cefpodoxime (free acid) 是一种口服的第三代头孢菌素抗生素。除铜绿假单胞菌、肠球菌和脆弱拟杆菌外，它对大多数革兰氏阳性和革兰氏阴性微生物均有效。

Cefpodoxime (free acid)

一键复制产品信息

很棒

纯度: 99.94%

货号 T4998L 别名 头孢泊肟Cas号 80210-62-4

规格	价格	库存
1 mg	¥ 187	现货
5 mg	¥ 446	现货
10 mg	¥ 733	现货
25 mg	¥ 1,530	现货
50 mg	¥ 2,280	现货
100 mg	¥ 3,390	现货
1 mL x 10 mM (in DMSO)	¥ 552	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.94%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Cefpodoxime (free acid) AI Summary

Cefpodoxime (free acid) exhibits moderate antibacterial activity against various bacterial strains, including Haemophilus influenzae, Escherichia coli, Neisseria gonorrhoeae, Salmonella enterica, Shigella sonnei, and Streptococcus pneumoniae. Its effectiveness is measured by Minimum Inhibitory Concentration (MIC) values, with varying degrees of potency against different strains, indicating potent activity against susceptible strains and decreased efficacy against resistant strains with specific genetic mutations. Additionally, it has shown antimicrobial activity against rifampin-resistant and beta-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae isolates, with MIC values ranging from 0.03 to 8.0 µg/mL. The compound also exhibits activity against Escherichia coli strains harboring the blaTEM-168 gene, with inhibitory zone diameters enhanced by clavulanic acid, and demonstrates moderate binding to plasma proteins in both humans (25.0% to 53.45%) and rats (54.59%). In human Caco-2 cells, Cefpodoxime (free acid) has shown insignificant binding affinity to the membrane transport protein PEPT1, with a Ki value greater than 30,000,000 nM. Additionally, the compound has a renal transport interaction with PepT2 in SKTP cells, showing a similar Ki value. It possesses moderate hepatotoxicity, indicated by elevated serum ALT or AST levels with a 33.3% observed frequency of moderate liver toxicity during clinical trials, although it showed no acute liver toxicity or severe hepatic side effects. Cefpodoxime (free acid) does not exhibit significant bioactivity in various receptor and enzyme assays, as evidenced by AC50 values exceeding 30,000 nM. The compound's pharmacokinetics reflect a low intrinsic clearance rate in rat hepatocytes and bioactivity related to specific biological compartments following oral administration, suggesting a potential for longer half-life. Overall, Cefpodoxime (free acid) demonstrates a broad spectrum of antibacterial activity with varying degrees of efficacy and moderate liver toxicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cefpodoxime (free acid) is an oral, third-generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms, except Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.
别名	头孢泊肟

化学信息

分子量	427.46
分子式	C₁₅H₁₇N₅O₆S₂
CAS No.	80210-62-4
Smiles	[H][C@]12SCC(COC)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c1csc(N)n1)C(O)=O
密度	1.78 g/cm3 (Predicted)

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (58.49 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3394 mL	11.6970 mL	23.3940 mL	116.9700 mL
5 mM	0.4679 mL	2.3394 mL	4.6788 mL	23.3940 mL
10 mM	0.2339 mL	1.1697 mL	2.3394 mL	11.6970 mL
20 mM	0.1170 mL	0.5849 mL	1.1697 mL	5.8485 mL
50 mM	0.0468 mL	0.2339 mL	0.4679 mL	2.3394 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

R-3763 R3763 R 3763 Inhibitor inhibit gram-positive bacteria gram-negative bacteria free acid Cefpodoxime acid Cefpodoxime (free acid)Cefpodoxime Bacterial Antibiotic

Cefpodoxime (free acid)

Cefpodoxime (free acid)