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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-NTR3 Antibody (3I276)

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货号 TMAB-09663

Anti-NTR3 Antibody (3I276) 是一种 Rabbit 抗体，靶向 NTR3。Anti-NTR3 Antibody (3I276) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-NTR3 Antibody (3I276)

Anti-NTR3 Antibody (3I276)

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Rating icon 还可以
货号 TMAB-09663

Anti-NTR3 Antibody (3I276) 是一种 Rabbit 抗体，靶向 NTR3。Anti-NTR3 Antibody (3I276) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-NTR3 Antibody (3I276) is a Rabbit antibody targeting NTR3. Anti-NTR3 Antibody (3I276) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
3I276
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:1000-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; IF: 1:100-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membraneprotein. Endoplasmic reticulum membrane; Single-pass type Imembrane protein (Potential). Endosome membrane; Single-pass type Imembrane protein (Potential). Golgi apparatus, Golgi stackmembrane; Single-pass type I membrane protein (Potential). Lysosomemembrane; Single-pass type I membrane protein (Potential). Nucleusmembrane; Single-pass type I membrane protein (Potential). Cellmembrane; Single-pass type I membrane protein; Extracellular side.Lysosome membrane; Single-pass type I membrane protein (Potential).Note=Localized to membranes of the endoplasmic reticulum,endosomes, Golgi stack, lysosomes and nucleus. A small fraction ofthe protein is also localized to the plasma membrane. May also befound in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes.Localization to the plasma membrane in adipocytes may be enhancedby insulin.
组织特异性Expressed at high levels in brain, spinalcord, heart, skeletal muscle, thyroid, placenta and testis.Expressed at lower levels in lymphoid organs, kidney, colon andliver.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex.
抗原信息
免疫原
A synthesized peptide: human Sortilin
抗原种属
Human
基因名称
SORT1
基因ID
6272
蛋白名称
Sortilin
Uniprot ID
Q99523
功能
Functions as a sorting receptor in the Golgi compartmentand as a clearance receptor on the cell surface. Required forprotein transport from the Golgi apparatus to the lysosomes by apathway that is independent of the mannose-6-phosphate receptor(M6PR). Also required for protein transport from the Golgiapparatus to the endosomes. Promotes neuronal apoptosis bymediating endocytosis of the proapoptotic precursor forms of BDNF(proBDNF) and NGFB (proNGFB). Also acts as a receptor forneurotensin. May promote mineralization of the extracellular matrixduring osteogenic differentiation by scavenging extracellular LPL.Probably required in adipocytes for the formation of specializedstorage vesicles containing the glucose transporter SLC2A4/GLUT4(GLUT4 storage vesicles, or GSVs). These vesicles provide a stablepool of SLC2A4 and confer increased responsiveness to insulin. Mayalso mediate transport from the endoplasmic reticulum to the Golgi.
化学信息
分子量Theoretical: 92 kDa. Actual: 92 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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