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Anti-BAX Polyclonal Antibody 3

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货号 TMAB-00189

别名 Bcl-2-like protein 4, Bcl2-L-4, BCL2L4, Apoptosis regulator BAX

Anti-BAX Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 BAX。Anti-BAX Polyclonal Antibody 3 可用于 WB。

Anti-BAX Polyclonal Antibody 3

Anti-BAX Polyclonal Antibody 3

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货号 TMAB-00189 别名 Bcl-2-like protein 4, Bcl2-L-4, BCL2L4, Apoptosis regulator BAX

Anti-BAX Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 BAX。Anti-BAX Polyclonal Antibody 3 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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生物活性
产品描述
Anti-BAX Polyclonal Antibody 3 is a Rabbit antibody targeting BAX. Anti-BAX Polyclonal Antibody 3 can be used in WB.
别名Bcl-2-like protein 4, Bcl2-L-4, BCL2L4, Apoptosis regulator BAX
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep)
验证活性
1. Sample:
Testis (Mouse) Lysate at 40 μg
Primary: Anti-Bax (TMAB-00189) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa
2. Sample:
Testis (Rat) Lysate at 40 μg
Primary: Anti-Bax (TMAB-00189) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa
verifiedActivityverifiedActivity
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential).
组织特异性Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lu
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated synthetic peptide: human Bax
抗原种属
Human
基因名称
BAX
基因ID
581
蛋白名称
Apoptosis regulator BAX
Uniprot ID
Q07812
研究领域
Bcl 2 family,Metabolism,Bcl 2 family,Associated Proteins,Bcl2 Family,Apoptosis marker and proteins ELISA kits,Apoptosis
功能
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
化学信息
分子量Theoretical: 21 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

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