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Sodium butanoate (Sodium Butyrate) 是 butyrate 的钠盐。Butyrate 是一种短链脂肪酸,一种 I 类和 II 类组蛋白脱乙酰酶 (HDAC) 的抑制剂,与锌位点竞争性结合。Sodium butanoate 具有潜在抗肿瘤活性。
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Sodium butanoate (Sodium Butyrate) 是 butyrate 的钠盐。Butyrate 是一种短链脂肪酸,一种 I 类和 II 类组蛋白脱乙酰酶 (HDAC) 的抑制剂,与锌位点竞争性结合。Sodium butanoate 具有潜在抗肿瘤活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 mg | ¥ 119 | In stock | |
500 mg | ¥ 195 | In stock | |
1 g | ¥ 290 | In stock | |
5 g | ¥ 538 | In stock | |
10 g | ¥ 787 | In stock |
Sodium butanoate 相关产品
产品描述 | Sodium butanoate (Sodium Butyrate) is the sodium salt of butyrate, a short-chain fatty acid, an inhibitor of class I and II histone deacetylases (HDAC), which binds competitively to the zinc site. Sodium butanoate has potential antitumor activity. |
靶点活性 | HDAC2:0.4 mM, HDAC7:0.3 mM, MCF7 cells proliferation:5.23 mM, LN-405 cells proliferation:26 mM, T98G cells proliferation:22.7 mM, HDAC1:0.3 mM, MDA-MB-231 cells proliferation:5.06 mM |
体外活性 | 方法:NPC 细胞系 5-8F 和 6-10B 用 Sodium butanoate (1-10 mM) 处理 24-72 h,使用 MTT assay 检测细胞活力。 |
体内活性 | 方法:为研究对亨廷顿舞蹈症 (HD) 的作用,将 Sodium butanoate (100-10000 mg/kg) 腹腔注射给 R6/2 小鼠,每天一次,持续至死亡。 |
细胞实验 | Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 μL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 μL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 μL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability. |
别名 | 丁酸钠, Sodium Butyrate, Butanoic acid sodium salt |
分子量 | 110.09 |
分子式 | C4H7NaO2 |
CAS No. | 156-54-7 |
Smiles | [Na+].CCCC(=O)[O-] |
密度 | 0.987g/cm3 |
存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 1.1 mg/mL (10 mM), Sonication is recommended. ![]() H2O: 100 mg/mL (908.35 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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