Powder: -20°C for 3 years | In solvent: -80°C for 2 years
RO 363 is an effective inotropic stimulant and is a cardiovascular modulator that decreases diastolic blood pressure and pronounces increases in myocardial contractility. Ro 363 is an effective and highly selective β1-adrenoceptor agonist.
|产品描述||RO 363 is an effective inotropic stimulant and is a cardiovascular modulator that decreases diastolic blood pressure and pronounces increases in myocardial contractility. Ro 363 is an effective and highly selective β1-adrenoceptor agonist.|
|体外活性||RO 363 is approximately half as effective as (-)-Isoprenaline in tissues where actions are due to β1-receptor activation (guinea-pig atrial and ileal preparations and ventricular strips from the rabbit, rat, and guinea-pig. In spontaneously contracted tracheal preparations from the guinea-pig, RO 363 is a full agonist and is approximately half as potent as (-)-Isoprenaline. These effects of RO 363 are due to the activation of a population of β1-receptors in the tissue since RO 363 and (-)-Isoprenaline have the same relative potencies in trachea, cardiac and ileal preparations. Isolated perfused heart preparations from guinea-pigs developed arrhythmic contractions following the administration of Ro 363 in doses producing 70-100% of its maximal chronotropic responses .|
|体内活性||Ro 363 elicits ventricular arrhythmias following the administration of subarrhythmic doses of ouabain and increases the number of subauricular escape beats which occurred during vagal nerve stimulation in non-ouabain treated animals. In chloralose-anesthetized cats, Ro 363, when compared to epinephrine, is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane .|
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法： 比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)， 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300， 混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。