Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Riboflavin Tetrabutyrate 是一种亲脂性黄素衍生物,具有抗氧化和脂质过氧化物去除活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 150 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 110 | 现货 |
产品描述 | Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity. |
体外活性 | Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. During the process of the enzymic oxidation-reduction reaction, Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids[1]. |
体内活性 | Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver, and so on through the inhibition of lipid peroxide, thereby resulting in a decrease of the elevated serum lipid. The increase in hepatic 3-ketoacyl-CoA thiolase activity indicates that prolonged Riboflavin Tetrabutyrate administration induces an increased beta-oxidation of fatty acid in the liver. Feeding of Riboflavin Tetrabutyrate causes an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected [1][2]. |
分子量 | 656.72 |
分子式 | C33H44N4O10 |
CAS No. | 752-56-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (152.27 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5227 mL | 7.6136 mL | 15.2272 mL | 38.068 mL |
5 mM | 0.3045 mL | 1.5227 mL | 3.0454 mL | 7.6136 mL | |
10 mM | 0.1523 mL | 0.7614 mL | 1.5227 mL | 3.8068 mL | |
20 mM | 0.0761 mL | 0.3807 mL | 0.7614 mL | 1.9034 mL | |
50 mM | 0.0305 mL | 0.1523 mL | 0.3045 mL | 0.7614 mL | |
100 mM | 0.0152 mL | 0.0761 mL | 0.1523 mL | 0.3807 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Riboflavin Tetrabutyrate 752-56-7 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species inhibit Inhibitor Riboflavin inhibitor