Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂,IC50分别为0.65 µM 和IC50 = 4.3 μM,是治疗炎症的潜在化合物。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,350 | 现货 | ||
5 mg | ¥ 5,630 | 现货 | ||
10 mg | ¥ 7,790 | 现货 | ||
25 mg | ¥ 11,200 | 现货 | ||
50 mg | ¥ 13,800 | 现货 | ||
100 mg | ¥ 17,500 | 现货 | ||
500 mg | ¥ 34,800 | 现货 |
产品描述 | LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation. |
靶点活性 | COX-2 (whole blood):4.3μM, COX-2 (human monocytes):0.65 µM |
体外活性 | We found that continuous exposure to cytostatic doses of CAI and LM-1685, a celecoxib analog, reduced the proliferation and survival of seven human cancer cell lines by at least one log (P < or = 0.001) over either agent alone. The supra-additive antiproliferative effects occurred throughout a range of LM-1685 doses (5-25 micromol/L) and paralleled a decrease in COX-2 activity as measured by prostaglandin E2 production. In these cells, treatment with LM-1685/CAI suppressed the extracellular signal-regulated kinase pathway within the first hour but ultimately results in high, sustained activation of ERK over a 9-day period (P = 0.0005). [1] |
别名 | LM 1685, LM1685 |
分子量 | 377.84 |
分子式 | C18H16ClNO4S |
CAS No. | 416901-58-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (238.2 mM)
Methanol: 0.9 mg/mL (2.3 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Methanol | 1 mM | 2.6466 mL | 13.2331 mL | 26.4662 mL | 66.1656 mL |
DMSO | 5 mM | 0.5293 mL | 2.6466 mL | 5.2932 mL | 13.2331 mL |
10 mM | 0.2647 mL | 1.3233 mL | 2.6466 mL | 6.6166 mL | |
20 mM | 0.1323 mL | 0.6617 mL | 1.3233 mL | 3.3083 mL | |
50 mM | 0.0529 mL | 0.2647 mL | 0.5293 mL | 1.3233 mL | |
100 mM | 0.0265 mL | 0.1323 mL | 0.2647 mL | 0.6617 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LM-1685 416901-58-1 Immunology/Inflammation Neuroscience COX LM 1685 LM1685 Inhibitor inhibitor inhibit