Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGS 15435是一种有效的血栓素(TxA2)合成酶抑制剂(IC50: 1 nM)。CGS 15435作用于 PGI2合成酶、环氧合酶和脂合酶比作用于血栓素合成酶选择性低得多。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,300 | 现货 | ||
5 mg | ¥ 5,570 | 现货 | ||
10 mg | ¥ 7,790 | 现货 | ||
25 mg | ¥ 11,500 | 现货 | ||
50 mg | ¥ 15,600 | 现货 | ||
100 mg | ¥ 20,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 6,530 | 现货 |
产品描述 | CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less selectivity than on thromboxin synthase. |
靶点活性 | TXA2:1 nM |
体外活性 | CGS 15435 inhibited the formation of PGE2 (IC50:1200 μM), PGI2 synthetase (IC50:90 μM) and 5-lipoxygenase (IC50:60 μM).[1] |
体内活性 | The effect of CGS 15435 was long lasting, as the increase of plasma TxB2 levels was prevented even 24 hours after the administration of CGS 15435. CGS 15435 inhibited the formation of TxB2 significantly at 4, 6, 12 and 24 h after administration. Administration of CGS 15435 0.25 or 24 h before arachidonic acid (AA) did not increase TxB2 in surviving animals (4/4 and 5/6, respectively). The final TxB2 level in CGS15435A(pretreatment for 0.25 and 24 h) groups was significantly lower than that in arachidonic acid (AA) and daxibon (pretreatment for 2 h) groups.[1] |
分子量 | 356.85 |
分子式 | C20H21ClN2O2 |
CAS No. | 95853-92-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.57 mg/mL (10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8023 mL | 14.0115 mL | 28.023 mL | 70.0574 mL |
5 mM | 0.5605 mL | 2.8023 mL | 5.6046 mL | 14.0115 mL | |
10 mM | 0.2802 mL | 1.4011 mL | 2.8023 mL | 7.0057 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CGS 15435 95853-92-2 DNA Damage/DNA Repair Metabolism PPAR CGS-15435 CGS15435 Inhibitor inhibitor inhibit