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Around 50 approved HIV medicines may serve as components of a personalized treatment regimen. Depending on a viral target and active substance, they form seven main drug classes. Various medications operate at different stages of the HIV life cycle: some of them prevent the virus from entering the immune system cells; others are able to block enzymes that HIV needs to replicate – reverse transcriptase, protease, and integrase. This variability of options stems from over 30 years of intense research efforts. However, the resulting ability to control HIV as a chronic disease is just a step towards complete recovery. The cure continues to be one of the greatest medical challenges, which motivates a permanent search for innovative anti-HIV drugs and treatment strategies. In response to this acute need, Life Chemicals contributes to antiretroviral research with a proprietary set of Anti-HIV Screening Libraries. Designed with a 2D fingerprint similarity approach, this Library contains over 16,800 drug-like screening compounds with potent antiretroviral activity.