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Search Results for " vancomycin "

30

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12242	Norvancomycin hydrochloride Desmethyl-vancomycin hydrochloride,盐酸去甲万古霉素	Antibacterial	Microbiology/Virology
	Norvancomycin hydrochloride (Desmethyl-vancomycin hydrochloride) 可用于葡萄球菌所致的心内膜炎、骨髓炎、肺炎、败血症或软组织感染。
T70020	Vancomycin monohydrochloride
	Vancomycin monohydrochloride is an amphoteric glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to peptidoglycan.
T40475	Ceftobiprole medocaril BAL5788,头孢比普酯	Antibacterial	Microbiology/Virology
	Ceftobiprole medocaril (BAL5788) 是 Ceftobiprole 的前药。Ceftobiprole 是一种广谱的头孢菌素，对耐甲氧西林金黄色葡萄球菌具有活性。
T70019	Tadalafil hydroxypiperidone
	Tadalafil hydroxypiperidone is an impurity of Tadalafil -- a phosphodiesterase 5-inhibitor used for the treatment of erectile dysfunction.
TQ0077	Ceftobiprole Ro 63-9141,BAL 9141,头孢吡普	Antibacterial	Microbiology/Virology
	Ceftobiprole (Ro 63-9141) 是一种广谱头孢菌素，对甲氧西林耐受的金黄色葡萄球菌的MIC90值为 2 μg/mL。
T37740	N-Demethylvancomycin (hydrochloride)
	N-Demethylvancomycin is a glycopeptide antibiotic that has been found inNocardia orientalis.1It is active against several strains ofS. aureusandS. epidermidisin vitroandin vivo.2Formulations containing N-demethylvancomycin have been used in the treatment of bacterial infections. 1.Boeck, L.D., Mertz, F.P., Wolter, R.K., et al.N-demethylvancomycin, a novel antibiotic produced by a strain of Nocardia orientalis. Taxonomy and fermentationJ. Antibiot. (Tokyo)37(5)446-453(1984) 2.Hunt, A.H., Marconi,...
T16748	Ridinilazole SMT19969	Antibacterial	Microbiology/Virology
	Ridinilazole (SMT19969) 是一种新型的窄谱非吸收性抗生素。它显示出对艰难梭菌的有效抑制作用 (MIC90=0.125 mg/L)，并且比甲硝唑 (MIC90 = 8 mg/L) 或万古霉素 (MIC90 = 2 mg/L) 更有效。
T4165	Delpazolid LCB01-0371	Antibacterial; Antibiotic	Microbiology/Virology
	Delpazolid (LCB01-0371) 是一种恶唑烷酮类新型抗生素，能抑制MSSA 和MRSA 的生长，对它们的MIC90值都为 2 μg/mL。
T23639	Adicillin NSC113137,NSC 113137,NSC-113137
	Adicillin is a penicillin antibiotic that works against vancomycin-resistant enterococci.
T27964	Voxvoganan LTX109,Lytixar,LTX-109,LTX 109
	Lytixar is a Synthetic Antimicrobial Peptide, it shows activity against Daptomycin-Nonsusceptible, Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Linezolid-Nonsusceptible Staphylococcus aureus. LTX-109 demonstrated a MIC range o
T29531	ABT-719 HCl A-816719.1,A 816719.1,ABT-719,ABT719,ABT 719,ABT-719 hydrochloride
	ABT-719 is a 2-pyridinone antimicrobial agent that is more effective against Enterococcus faecalis strains than ciprofloxacin and vancomycin, which showed resistance to ciprofloxacin and vancomycin covering a range of MIC.
T61799	Antibacterial agent 75
	Antibacterial agent 75 (compound 24) possesses antibacterial properties. Its notable attribute is the ability to re-sensitize VRSA (Vancomycin-Resistant Staphylococcus aureus) strains to vancomycin, as reported in reference [1].
T37465	CAY10742
	CAY10742 is an orally bioavailable oxadiazole antibiotic.1It is active against the Gram-positive bacteriaS. aureus,S. epidermidis,S. haemolyticus,B. cereus,B. licheniformis,E. faecalis, andE. faecium(MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin...
T1747L	Tedizolid phosphate disodium salt Torezolid phosphate sodium salt,DA 7218,TR-701,TR 701
	Tedizolid phosphate is a novel antibacterial prodrug. Tedizolid phosphate is a next-generation oxazolidinone with activity against both methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp. It also has effective activity a
T69176	YycG inhibitor 16
	YycG inhibitor 16 is a novel YycG inhibitor, inhibiting planktonic cells of E. faecalis, including the vancomycin- or linezolid-resistant strains.
T37263	14-methyl Pentadecanoic Acid methyl ester
	14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae. It is a major component of the vancomycin-induced biofilm produced by vancomycin-resistant S. aureus (VRSA). 14-methyl Pentadecanoic acid methyl ester has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS.
TP2286	Quinupristin (mesylate) (120138-50-3 free base) Quinupristin (mesylate)	Others	Others
	Quinupristin is a streptogramin antibiotic. Streptogramins, a class of antibiotics, is effective in the treatment of vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus, which are two of the most rapidly growing strains of mul
T38178	Ristocetin A (sulfate) Ristomycin III
	Ristocetin A, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism Nocardia lurida[1]. Ristocetin A is currently in clinical use to treat bacterial infections [1]. Ristocetin A is an antibiotic which can be used to treat staphylococcal infections. The side effects of ristocetin A include thrombocytopenia and platelet agglutination. Ristocetin A has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. These t...
T32777	Lipid II binder 5107930 Compound 5107930
	Lipid II binder 5107930 is a lipid II binder which causes specific upregulation of the vancomycin-resistance associated gene vraX, which is implicated in the cell wall stress stimulon that confers glycopeptide resistance.
T38125	Platencin
	Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including ...
T36706	Bottromycin A2
	Bottromycin A2is an antibiotic originally isolated fromStreptomyces.1It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2Bottromycin A2is active against clinical isolates of methicillin-resistantStaphylococcus aureus(MRSA) and vancomycin-resistantEnterococciwith MIC values of 1 and 0.5 μg/ml, respectively. 1.Nakamura, S., Yajima, T., Lin, Y., et al.Isolation and characterization of bottromycins A2, B2, C2J. Antibiot. (Tokyo)20(1)1-5(1967) 2.Go...
T80193	Enterocin Hybrid 1 K1-EJ hybrid
	Enterocin Hybrid 1为抗菌剂，具有抗菌组合物特性，能抑制对万古霉素具耐药性的大肠杆菌、粪肠球菌及溶血葡萄球菌。
T76990	Suvratoxumab
	Suvratoxumab (MEDI4893) 是一种长效且具有亲和力高的人源化抗 α-毒素单克隆抗体(IgG1κ 型)。Suvratoxumab 能有效中和 α-毒素 (一种关键的金黄色葡萄球菌毒力因子)。Suvratoxumab 可提高免疫功能低下的小鼠肺炎模型的存活率并减少肺损伤。Suvratoxumab 还可增强Vancomycin 或Linezolid 的抗菌活性。
T74269	Antibacterial agent 83
	Antibacterial agent 83 (compound 17h) 对各种耐万古霉素 Enterococcus faecalis(VRE) 和耐甲氧西林 Staphylococcus aureus(MRSA) 显示出有效的抗菌活性。Antibacterial agent 83 可以显着减少 MRSA 的生物膜形成，并表现出良好的选择性。Antibacterial agent 83 在人肝微粒体中代谢稳定。
T36892	4'-Acetyl Chrysomycin A
	4'-Acetyl chrysomycin A is a bacterial metabolite and derivative of chrysomycin A that has been found inStreptomycesand has antibacterial and anticancer activities.1It is active against strains of methicillin-resistantS. aureus(MRSA) and vancomycin-resistant strains ofE. faecalisandE. faecium(MICs = 0.5-2 μg/ml for all). 4'-Acetyl chrysomycin A is cytotoxic against a panel of human cancer cell lines, including doxorubicin-sensitive or -resistant cells (IC50s = 0.085-0.26 and 3.4-16 ng/ml, respec...
T38009	Kocurin
	Kocurin is a thiazolyl peptide originally isolated fromK. palustrisand has antibiotic activity.1It is active against methicillin-resistantS. aureus(MRSA; MIC = 0.25 μg/ml), as well asB. subtilisandE. faeciumin a solid agar test when used at a concentration of 8 μg/ml. Kocurin is also active againstE. faecium,E. faecalis,S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 μg/ml).2In vivo, kocurin (2.5, 5, and 10 mg/ml) increases survival in a mouse model ...
T37006	Previridicatumtoxin
	Previridicatumtoxin is a fungal metabolite that has been found inP. aethiopicumand has diverse biological activities.1,2It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin . Previridicatumtoxin is active against methicillin-resistantS. aureus(MRSA) and vancomycin-resistantE. faecalis(IC50s = 4.4 and 4.8 μM, respectively), as well asC. albicansandS. cerevisiae(MIC = 32 μg/ml for both).2,1It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC50s = 5.3, 4.1, and 6 μ...
T72141	Ceftobiprole medocaril sodium 头孢比普酯钠盐,BAL5788 sodium
	Ceftobiprole medocaril (BAL5788) sodium 是 Ceftobiprole 的胃肠外前药。Ceftobiprole 是一种非肠道吡咯烷酮头孢菌素。Ceftobiprole 是一种广谱头孢菌素，对甲氧西林 (MRSA) 和耐万古霉素葡萄球菌 (VRSA) 和耐青霉素链球菌具有高水平的体外活性。Ceftobiprole 也抑制革兰氏阳性和革兰氏阴性病原体。
T80192	Enterocin K1 EntK1
	Enterocin K1 (EntK1)是一种细菌素bacteriocin，同时也属于核糖体合成肽类。该化合物通过特异性与粪肠球菌Enterococcus faecalis的Eep蛋白结合发挥作用，对耐甲氧西林的粪肠球菌VRE表现出显著的抗菌活性。Enterocin K1主要用于研究与VRE感染相关的治疗策略。
T35437	(-)-Viriditoxin
	(-)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity. It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml). (-)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MI...

化合物

Norvancomycin hydrochloride

Cat.No: T12242

Synonym: Desmethyl-vancomycin hydrochloride,盐酸去甲万古霉素

Target: Antibacterial

Vancomycin monohydrochloride

Cat.No: T70020

Ceftobiprole medocaril

Cat.No: T40475

Synonym: BAL5788,头孢比普酯

Target: Antibacterial

Tadalafil hydroxypiperidone

Cat.No: T70019

Cat.No: TQ0077

Synonym: Ro 63-9141,BAL 9141,头孢吡普

Target: Antibacterial

N-Demethylvancomycin (hydrochloride)

Cat.No: T37740

Cat.No: T16748

Synonym: SMT19969

Target: Antibacterial

Cat.No: T4165

Synonym: LCB01-0371

Target: Antibacterial, Antibiotic

Cat.No: T23639

Synonym: NSC113137,NSC 113137,NSC-113137

Cat.No: T27964

Synonym: LTX109,Lytixar,LTX-109,LTX 109

Cat.No: T29531

Synonym: A-816719.1,A 816719.1,ABT-719,ABT719,ABT 719,ABT-719 hydrochloride

Antibacterial agent 75

Cat.No: T61799

Cat.No: T37465

Tedizolid phosphate disodium salt

Cat.No: T1747L

Synonym: Torezolid phosphate sodium salt,DA 7218,TR-701,TR 701

YycG inhibitor 16

Cat.No: T69176

14-methyl Pentadecanoic Acid methyl ester

Cat.No: T37263

Quinupristin (mesylate) (120138-50-3 free base)

Cat.No: TP2286

Synonym: Quinupristin (mesylate)

Target: Others

Ristocetin A (sulfate)

Cat.No: T38178

Synonym: Ristomycin III

Lipid II binder 5107930

Cat.No: T32777

Synonym: Compound 5107930

Cat.No: T38125

Cat.No: T36706

Enterocin Hybrid 1

Cat.No: T80193

Synonym: K1-EJ hybrid

Cat.No: T76990

Antibacterial agent 83

Cat.No: T74269

4'-Acetyl Chrysomycin A

Cat.No: T36892

Cat.No: T38009

Previridicatumtoxin

Cat.No: T37006

Ceftobiprole medocaril sodium

Cat.No: T72141

Synonym: 头孢比普酯钠盐,BAL5788 sodium

Cat.No: T80192

Synonym: EntK1

(-)-Viriditoxin

Cat.No: T35437

Cat. No.	Product Name	Target	Signaling Pathways
T8641	Vancomycin	Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Vancomycin 是一种糖肽类抗生素，可以通过改变细胞膜的渗透性并选择性地抑制核糖核酸的合成以发挥抗菌活性。Vancomycin 可以用于治疗所有抗生素均无效的严重感染。
T0832	Vancomycin hydrochloride 盐酸万古霉素,Vancomycin HCl	Cell wall; Antibacterial; Antibiotic; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Vancomycin hydrochloride (Vancomycin HCl) 是Vancomycin 的盐酸盐，是一种支链三环糖基化肽，对大多数生物体具有杀菌活性，对肠球菌具有抑菌作用。
TN1342	8-Epidiosbulbin E acetate 8-表黄药子素E乙酸酯	Anti-infection; Antibacterial	Microbiology/Virology
	8-Epidiosbulbin E acetate 是从 Dioscorea bulbifera L.中发现的呋喃类化合物，对耐多药细菌具有广谱的质粒治疗活性。
TN4148	Glyasperin C	Tyrosinase; Antifection	Microbiology/Virology; Proteases/Proteasome
	Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidate in the design of skin-whitening agents. Glyasperin C shows potent anti-vancomycin-resistant
T75278	Pristinamycin
	Pristinamycin, 一种 Streptomyces pristinaespiralis 产生的口服活性链霉素样抗生素，由化学上不相关的两部分组成：Pristinamycin I (PI) 与 Pristinamycin II (PII)。该药物对包括耐甲氧西林金黄色葡萄球菌 (MRSA)、万古霉素耐药金黄色葡萄球菌 (VRSA) 和粪肠球菌 (VREF) 在内的多种抗生素耐药革兰氏阳性菌表现出强大活性。
TN2977	3-O-trans-p-Coumaroyltormentic acid	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an...

天然产物

Cat.No: T8641

Target: Antibacterial, Antibiotic, Autophagy

Vancomycin hydrochloride

Cat.No: T0832

Synonym: 盐酸万古霉素,Vancomycin HCl

Target: Cell wall, Antibacterial, Antibiotic, Autophagy

8-Epidiosbulbin E acetate

Cat.No: TN1342

Synonym: 8-表黄药子素E乙酸酯

Target: Anti-infection, Antibacterial

Cat.No: TN4148

Target: Tyrosinase, Antifection

Cat.No: T75278

3-O-trans-p-Coumaroyltormentic acid

Cat.No: TN2977

Target: Caspase, Antifection

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