42
2
Cat. No. | Product Name | Target | Signaling Pathways |
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T9303 |
MRTX1133
|
Ras | GPCR/G Protein; MAPK |
MRTX1133 是一种 KRAS G12D 抑制剂 (KD=0.2 pM),具有强效性、选择性和非共价性。MRTX1133 对 KRAS G12D 突变的肿瘤具有抑制活性,而对 KRAS 野生型肿瘤无抑制活性。 | |||
T0411 |
Gluconate Calcium
Calcium D-gluconate,Gluconic acid hemicalcium salt,Calcium gluconate,葡萄糖酸钙 |
Others | Others |
Gluconate Calcium (Gluconic acid hemicalcium salt) 是矿物质补充剂, 由葡糖酸和石灰或碳酸钙中和制成。 | |||
T10674 |
Potassium Channel Activator 1
钾离子通道激活剂1,ZINC34634569 |
Potassium Channel | Membrane transporter/Ion channel |
Potassium Channel Activator 1 可用于治疗多巴胺能系统被破坏的疾病或病症的研究,例如情绪障碍 ADHD、精神分裂症和其他精神病状态。 | |||
T20702 |
Ormetoprim
Ro5-9754,奥美普林,Ro 5-9754,Ro-5-9754 |
Antibiotic | Microbiology/Virology |
Ormetoprim (Ro 5-9754) 是一种兽用抗菌剂,通常用于水产养殖和家禽行业,可以预防疾病在淡水水产养殖中的传播,促进家畜的生长。 | |||
T0285 |
Isoxicam
伊索昔康,Isoxicamum,Isoxicamo,Maxicam |
COX | Immunology/Inflammation; Neuroscience |
Isoxicam (Isoxicamum) 是可口服的非甾体抗炎剂,可通过抑制环氧合酶 1 和 2 来阻断前列腺素的合成,可用于关节炎的研究。 | |||
T3285 |
Eslicarbazepine Acetate
Zebinix,Aptiom,BIA 2-093,Exalief,艾司利卡西平醋酸酯,Stedesa |
Beta-Secretase; Sodium Channel | Membrane transporter/Ion channel; Neuroscience |
Eslicarbazepine Acetate (Zebinix) 是一种抗癫痫药物。Eslicarbazepine acetate 也是 β-内分泌酶(β-Secretase)和电压门控钠离子通道的双抑制剂。 | |||
T1175 |
Bromopride
Bromoprida,溴灭吐灵,Valopride,Artomey |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Bromopride (Valopride) 是一种多巴胺拮抗剂,常用作止吐药,有促动力特性。 | |||
T1442 |
Pizotifen
Pizotyline,BC-105,苯噻啶 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Pizotifen (Pizotyline) 是5-HT2受体的有效拮抗剂,并对5-HT1C 有高亲和力。它是一种强血清素和色胺拮抗剂,具有较弱的抗胆碱能、抗组胺和抗激肽作用,还具有镇静和刺激食欲的特性。 | |||
T16472 |
Pericyazine
Propericiazine,氰噻嗪,RP 8909 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Pericyazine (Propericiazine) 是第一代抗精神病药物,是一种选择性的 D2 多巴胺受体 (D2-dopamine receptor) 拮抗剂,具有肾上腺溶解、抗胆碱能和锥体外系作用,被用作短期管理严重焦虑状态和精神病的辅助药物。 | |||
T2189 |
Sodium orthovanadate
Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate |
ATPase; Phosphatase | Membrane transporter/Ion channel; Metabolism |
Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶,碱性磷酸酶和一些ATP 酶的抑制剂,有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。 | |||
T2585 |
Bedaquiline
R207910,TMC207,贝达喹啉 |
Antibacterial; Antibiotic | Microbiology/Virology |
Bedaquiline (R207910) 是一种二芳基喹啉药物,能同时靶向 c-亚基和 ε-亚基,抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。 | |||
T0811 |
Amisulpride
DAN 2163,氨磺必利,阿米舒必利 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Amisulpride (DAN 2163) 是多巴胺D2/D3受体拮抗剂,对于人多巴胺D2和D3的Ki 分别为 2.8 和 3.2 nM。 | |||
T1519L |
Rimonabant
SR141716,利莫那班 |
Cannabinoid Receptor; Antibacterial; Acyltransferase | GPCR/G Protein; Metabolism; Microbiology/Virology |
Rimonabant (SR141716) 是一种选择性的、能透过血脑屏障的中心大麻素受体 1 拮抗剂, Ki 值为 1.8 nM。它也能够抑制分枝杆菌膜蛋白 3。 | |||
T0454 |
Florfenicol
氟苯尼考,Nuflor,Aquafen |
Others | Others |
Florfenicol (Aquafen) 是甲砜霉素的氟化合成类似物。在美国,氟苯尼考目前用于治疗与溶血性曼氏杆菌(巴氏杆菌)、多杀性巴氏杆菌和嗜血嗜血杆菌相关的牛呼吸道疾病(BRD),以治疗与坏死梭杆菌和黑色素拟杆菌相关的牛趾间痰。 | |||
T1551 |
Tegaserod maleate
HTF-919,马来酸替加色罗,SDZ-HTF-919 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Tegaserod maleate (SDZ-HTF-919) 是选择性5-HT4受体的部分激动剂和5-HT2B 受体的拮抗剂,用于治疗肠易激综合征和便秘。 | |||
T0454L |
Florfenicol
SCH-25298,氟苯尼考,(-)-Florfenicol |
Antibacterial; Antibiotic | Microbiology/Virology |
Florfenicol (SCH-25298) 是一种常见得兽用抗生素,能用于研究牛呼吸疾病,在水产养殖业中可以用来控制鲶鱼肠道败血病,也可诱导鸡蛋早期胚胎死亡,LC50 值为 1.07 μg/g。 | |||
T0910 |
Terpin hydrate
Terpin Monohydrate,cis-Terpin hydrate,萜品(水合结晶) |
Others | Others |
Terpin hydrate 是一种祛痰药,可除去急慢性支气管炎病人的黏液。 | |||
T36816 |
S-trityl-L-Cysteine
STLC |
Kinesin | Cytoskeletal Signaling |
S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM,抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。 | |||
T34903 |
TO-PRO3 iodide
TOPRO3 iodide,TO-PRO3 iodide salt |
||
TO-PRO3 iodide is a nucleic acid stain that can stain the nucleus of cells in different states, including living, early apoptotic, and necrotic cells. | |||
T11913 |
LY88074 Methyl ether
|
Others | Others |
LY88074 Methyl ether is effective in inhibiting conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia, which occur due to various estrogen-deficient states. | |||
T70854 |
Protokylol hydrochloride
|
||
Protokylol hydrochloride is the salt form of Protokylol (free base) (Asmetil, Caytine, Palison, Ventaire), a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States. It is methylenedioxyphenyl-isoproterenol. | |||
T31819 |
Fluometuron
NCI C08695,Ciba 2059,C 2059,NCI-C08695,NCIC08695 |
||
Fluometuron is an herbicide. In the United States it was approved for use on cotton and sugarcane crops in 1974, but since 1986 is only approved for use on cotton. | |||
T13263 |
COX/5-LO-IN-1
Atreleuton analog |
COX | Immunology/Inflammation; Neuroscience |
COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states. | |||
T27521 |
GX-936
GX 936,PF 05196233,PF05196233,GX936,PF-05196233 |
||
GX-936, a Nav1.7 inhibitor, inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel. | |||
T37130 | MRTX1133 formic | ||
MRTX1133 is a highly selective, first-in-class inhibitor of KRAS G12D. MRTX1133 targets the KRAS G12D protein in both active and inactive states. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells[1][2]. MRTX1133 demonstrates dose-dependent inhibition of the KRAS pathway tumor regression in G12D mutant tumor models[2]. [1]. Xiaolun Wang, et al.Kras g12d inhibitors.WO2021041671A1.[2]. KRAS G12D Inhibitor: MRTX1133. [(accessed on 22 April 2021)];2021 Available onli... | |||
T70613 |
SLP120701 HCl
|
||
SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease. | |||
T0338 |
Minaprine
Cantor,Minaprine dihydrochloride,米那卜林,米那卜林 二盐酸盐,Minaprina,Minaprinum |
MAO; Dopamine Receptor; 5-HT Receptor; AChR; AChE; Monoamine Oxidase | GPCR/G Protein; Metabolism; Neuroscience |
Minaprine 是一种单胺氧化酶 MAO-A 可逆性抑制剂,对乙酰胆碱酯酶有微弱抑制,是一种抗抑郁类化合物。 | |||
T4497L |
Amifampridine phosphate
BRN0110232,3,6-DAP,SC10,BRN 0110232,BRN-0110232,NSC 521760 |
||
Amifampridine is mainly used to treat many rare muscle diseases. In the United States, aminopyridine is being studied for the treatment of Lambert-Eaton myasmus syndrome (LEMS). Amifampridine is also used to treat many congenital myasthenia syndromes, par | |||
T70614 |
SLR080811 HCl
|
||
SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease. | |||
T33287 |
Mephentermine Sulfate
sulfuric acid,MLS002153976,N,2-dimethyl-1-phenylpropan-2-amine,AC1NWAW7,Mephentermine sodium |
||
Mephentermine sulfate is a cardiac stimulant, before as a stimulant in psychiatry, has been used as a treatment for low blood pressure. Mephentermine sulfate is a sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maint | |||
T75970 |
Melanin Concentrating Hormone, salmon TFA
|
||
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是在硬骨鱼的垂体中发现的 19 个氨基酸组成的神经肽,它调节食物摄入,能量平衡,睡眠状态和心血管系统。Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是 SLC-1/GPR24和 MCHR2的配体。 | |||
T70900 | VT-ME6 | ||
VT-ME6 is a potent and selective sphingosine kinase 2 inhibitor. VT-ME6, contained a quaternary ammonium group as a warhead and established that a positively charged moiety is necessary for engaging key amino acid residues in the enzyme binding pocket.13,14 This compound is moderately potent (Ki = 8 lM) and displays three-fold selectivity for SphK2 over SphK1. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK... | |||
T69492 |
Ozarelix
|
||
Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer,... | |||
T22572 | Angiotensin 1/2 (1-7) amide | Others | Others |
Angiotensin I/II (1-7) amide is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse. Angiotensin I/II amide is an amide derivative of angiotensin II that is a powerful vasoco | |||
T70128 |
Olmutinib hydrochloride
|
||
Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor, used in the treatment of T790M mutation positive non-small cell lung cancer. Olmutinib covalently binds a cysteine residue near the kinase domain of mutant EGFRs to prevent phosphorylation of the receptor. EGFRs are frequently over-expressed in lung cancer and contribute to activation of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways which both p... | |||
T31194 |
Dalapon
Basfapon B,Dowpon M,Dawpon-Rae |
||
Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the | |||
T82805 |
Butaprost free acid
|
||
(R)-Butaprost (free acid) 是PGE2的一个结构类似物,特异性地对EP2受体亚型有选择性。该化合物用于药理学研究,以确定不同人类及动物组织和细胞中EP受体的分布。去除甲酯基团并恢复C-1自然羧酸后,增强了(R)-butaprost与前列腺素受体的结合亲和力,通常情况下,游离酸形式的亲和力是相应酯形式的10到100倍。尽管(R)-butaprost作为C-16的较低活性差向异构体,其药理作用未经充分研究,但在1986年Gardiner的论文中提到的TR 4979即布他前列素,结构中的差向异构体错误表达为16(R),实际为16(S),该错误直至1990年代后期才被美国和日本的研究纠正。 | |||
T35961 |
Prostaglandin Bx
|
||
PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2.2,3 At a dose of 1 mg/kg, PGBx significantly reduces the incidence of ulcers in rats.2References1. Polis, B.D., Polis, E., and Kwong, S. Protection and reactivation of oxidative phosphorylation in mitocho... | |||
T35538 |
HPI-1 (hydrate)
HPI-1 hydrate |
||
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, prev... | |||
T38161 |
STING Agonist C11
STING Agonist C11 |
||
STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro... | |||
T35904 |
O-11
|
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O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface gl... | |||
T35568 |
BODIPY-aminoacetaldehyde diethyl acetal
|
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BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the effl... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21532 |
Anisodamine
6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine |
AChR | Neuroscience |
Anisodamine (6-beta-Hydroxyhyoscyamine) 是毒蕈碱和烟碱胆碱受体的拮抗剂,对毒蕈碱受体的亲和力与东莨菪碱和阿托品相似。 Anisodamine 改善休克状态下的微循环,可用于有机磷中毒的研究。 | |||
T4S0797 |
Berberine
小檗碱,Berberin,Umbellatine,黄连素 |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶,具有抗肿瘤特性。 |