pump 1

Bafilomycin A1 属于大环内酯类抗生素，是一种 V-ATPase 抑制剂 (IC50=0.44 nM)，具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂，阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。

Ursodeoxycholic acid (UDCA)是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂，通过 FATP5 依赖性方式抑制原代肝细胞摄取长链脂肪酸。Ursodeoxycholic acid 能够抑制胆固醇的吸收，用于溶解胆结石，并具有研究与肥胖相关的脂肪肝疾病的潜力。

Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂，可研究糖尿病和肥胖。它抑制 P-糖蛋白，可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能，可诱导自噬。

Ginsenoside Rb1 (Gypenoside Ⅲ) 是中药人参的成分，可能具有抑制或阻止肿瘤生长的特性。

Abeprazan (DWP14012) is a potassium-competitive acid blocker and it is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic

Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇，可抑制Na+ K+-ATPase 活性，IC50为 620 nM。

5-Hydroxylansoprazole (AG1908) 是血浆中 Lansoprazole 的活性代谢产物，对质子泵有抑制作用，可用于研究消化性溃疡。

DS-8587 is a DNA topoisomerase inhibitor. DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. DS-8587 significantly reduces the number of viabl

BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the efflux pump P-glycoprotein (P-gp) but co-application of BAAA with a P-gp inhibitor, such as verapamil , inhibits BAA efflux.2BAAA-DA has been used to isolate human hematopoietic progenitor cells, which have high ALDH activity, andviaflow cytometry to sort cancer stem cells that contain high levels of ALDH.1,3BAA used in cells can be excited at 488 nm and displays an emission maximum of 512 nm.4 1.Storms, R.W., Trujillo, A.P., Springer, J.B., et al.Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activityProceedings of the National Academy of Sciences of the United States of America96(16)9118-9123(1999) 2.Smith, C.A., Colvin, M., Storms, R.W., et al.BODIPY aminoacetaldehyde diethyl acetal08010501.81-15(2010) 3.Leng, Z., Yang, Z., Li, L., et al.A reliable method for the sorting and identification of ALDHhigh cancer stem cells by flow cytometryExp. Ther. Med.(2017) 4.Pomper, M.G., Wang, H., Minn, I., et al.Red fluorescent aldehyde dehydrogenase (ALDH) substrate(2015)

5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+ K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase. [2][3] CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.[1]

Caloxin 2A1 acetate 是细胞外质膜 Ca2+-ATPase (PMCA) 肽的抑制剂。 Caloxin 2A1 acetate 抑制 140-kDa 酸稳定酰基磷酸盐的 Ca2+ 依赖性形成。

Esomeprazole magnesium salt is a potent and orally active proton pump inhibitor that effectively reduces acid secretion in gastric parietal cells by inhibiting the H+, K+-ATPase. This compound has shown promise for the research and treatment of symptomatic gastroesophageal reflux disease [1][2][3].

Vonoprazan hydrochloride 是一种高效且具口服活性的质子泵抑制剂 (PPI) 和钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB)，展示出优秀的抗分泌活性。在 pH 为 6.5 的条件下，该化合物可抑制猪胃微粒体内 H+,K+-ATPase 的酶活性，呈现出 19 nM 的 IC50 值。Vonoprazan hydrochloride 主要应用于胃酸相关疾病的研究，包括胃食管反流病和消化性溃疡，并可用于根除幽门螺杆菌。

Esomeprazole potassium salt ((S)-Omeprazole potassium salt) is an effective and orally active proton pump inhibitor that works by inhibiting the H+, K+-ATPase enzyme in the gastric parietal cells, leading to a reduction in acid secretion. It is a promising compound for investigating symptomatic gastroesophageal reflux disease [1] [2] [3].

Esomeprazole hemistrontium, also known as (S)-Omeprazole, is a potent and orally active proton pump inhibitor that effectively reduces acid secretion by inhibiting the H+, K+-ATPase in gastric parietal cells. This compound exhibits promising potential for research in symptomatic gastroesophageal reflux disease [1] [2] [3].

Tenatoprazole (TU-199) 是一种口服有效的，基于咪唑吡啶的质子泵抑制剂。它抑制猪胃H+ K+-ATP 酶活性，IC50为6.2 μM。它阻断泛素与 ESCRT-1 因子 Tsg101 的相互作用，抑制几种包膜病毒的产生，包括 EBV。

Dexverapamil is the R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms.

Ilaprazole sulfone 是Ilaprazole 的主要代谢物，主要由 CYP3A4 5 催化。Ilaprazole (IY-81149) 是一种口服活性质子泵抑制剂。

Efflux pump-IN-2 是一种 AcrB 外排泵抑制剂，能够增强抗生素的作用。Efflux pump-IN-2 抑制尼罗红 (AcrB 的一种已知底物) 外排。Efflux pump-IN-2 不破坏细菌外膜，也不会在线虫模型中显示毒性。

Efflux pump-IN-3为一种AcrB外排泵抑制剂，具有增强抗生素效力的特性。该化合物能阻断尼罗红（AcrB已知的一种底物）的外排，而不会破坏细菌的外膜，并且在线虫模型中未展现出毒性。

Efflux pump-IN-4是一种针对AcrB外排泵的抑制剂，能够增强抗生素效果。该化合物通过抑制尼罗红（AcrB的已知底物）的外排来发挥作用，同时不破坏细菌外膜，且在线虫模型中未显示出毒性。

BDM91270（化合物 29），为大肠杆菌AcrAB-TolC外排泵抑制剂，EC90值针对野生型大肠杆菌AcrB为0.6 μM。适用于研究大肠杆菌的耐药性。

Ilaprazole sodium hydrate (IY-81149 sodium hydrate) 是一种具有口服活性的质子泵抑制剂，具有潜在的抗病毒活性，抑制 H+ K+-ATPase，可阻断培养物中 Vero 细胞的传染性单纯疱疹病毒 （HSV）-1 2 释放，阻断 HSV 颗粒的转运。

Antifungalagent 72（Compound B8）是一款高效抗真菌药物。该化合物通过抑制Pdr1-KIX相互作用（Ki：11.7μM）来干扰外排泵功能，并降低与耐药性相关的基因表达。Antifungalagent 72对抗氟康唑（Fluconazole）耐药的C. glabrata 0161菌株显示出显著的抗菌活性，其MIC值为63 ng mL，并与氟康唑合用时表现出协同效果。此化合物可应用于C. glabrata感染的相关研究。