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TargetMol产品目录中 "

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  • 抑制剂&激动剂
    25
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    11
    TargetMol | Recombinant_Protein
  • 多肽产品
    2
    TargetMol | Peptide_Products
  • PROTAC
    1
    TargetMol | PROTAC
  • 检测抗体
    4
    TargetMol | Antibody_Products
  • PRO-HD2
    T81393
    PRO-HD2为针对HDAC6的细胞特异性PROTAC降解剂。
    • 待询
    规格
    数量
  • Givinostat hydrochloride monohydrate
    ITF-2357 hydrochloride monohydrate, Gavinostat hydrochloride monohydrate
    T6279732302-99-7
    Givinostat hydrochloride monohydrate (ITF2357) 是一种HDAC 抑制剂,对HDAC1和HDAC3的IC50分别为 198 nM 和 157 nM。
    • ¥ 177
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Givinostat hydrochloride
    ITF2357 hydrochloride, ITF-2357 HCl, ITF2357 HCl, ITF 2357 HCl, Givinostat HCl
    T6279L199657-29-9
    Givinostat hydrochloride (ITF2357 hydrochloride) 是一种 HDAC 抑制剂,对 HDAC1 和 HDAC3 的 IC50 分别为 198 和 157 nM。 Givinostat hydrochloride 具有抗炎、抗血管生成和抗肿瘤活性。
    • ¥ 315
    In stock
    规格
    数量
  • HD-2a
    T82229606148-05-4
    HA-2a通过降低RAW264.7细胞内circDcbld2的表达,从而抑制JAK2 STAT3信号传导途径。
    • 待询
    8-10周
    规格
    数量
  • IOX2
    JICL38, IOX 2
    T1823931398-72-0
    IOX2 (IOX 2) 是特异性的脯氨酰羟化酶-2 抑制剂,IC50=22 nM。
    • ¥ 236
    In stock
    规格
    数量
  • Molidustat
    BAY 85-3934
    T26521154028-82-6
    Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂,对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。
    • ¥ 178
    In stock
    规格
    数量
  • Adaptaquin
    T22022385786-48-1
    Adaptaquin 是缺氧诱导因子脯氨酰羟化酶(HIF-PH)的抑制剂。
    • ¥ 131
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • FG-2216
    YM-311, FG2216, FG 2216
    T2445223387-75-5
    FG-2216 (YM-311) 是一种有效的、口服具有活力的HIF 脯氨酰羟化酶-2 (PHD2) 抑制剂,IC50=3.9 nM。它在体内能够诱导促红细胞生成素生成和胎儿血红蛋白的表达。
    • ¥ 298
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Izilendustat
    T643361303512-02-8
    tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate 是一种脯氨酰羟化酶抑制剂。
    • ¥ 170
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • JHD205
    T201023
    JHD205为CDK4 6抑制剂类化合物。
    • 待询
    规格
    数量
  • PHD2-IN-4
    T2055622924181-60-0
    PHD2-IN-4 (compound 1) 是一种PHD2抑制剂,其对PHD2的抑制IC50为4 nM,可用于慢性肾病研究。
    • 待询
    10-14周
    规格
    数量
  • JNJ-42041935
    HIF-PHD Inhibitor II
    T31801193383-09-3
    JNJ-42041935 (HIF-PHD Inhibitor II) 是一种高效的,竞争性的、选择性的脯氨酰羟化酶PHD 抑制剂,抑制PHD1(pKi= 7.91±0.04),PHD2 (pKi= 7.29 ±0.05) 和 PHD3 (pKi= 7.65±0.09)。
    • ¥ 348
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Givinostat
    T36629497833-27-9
    Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 100 and 200 nM, there is no reduction[1]. As shown by the CCK-8 assay, Givinostat (ITF-2357) inhibits JS-1 cell proliferation in a concentration-dependent manner. Treatment with Givinostat ≥500 nM is associated with significant inhibition of JS-1 cell proliferation (P<0.01). Also, the cell inhibition rate significantly differs between the group cotreated with Givinostat ≥250 nM plus LPS and the group without LPS treatment (same Givinostat concentration) (P<0.05)[2]. Givinostat (ITF2357) at 10 mg kg is used as a positive control and, as expected, reduced serum TNFα by 60%. Strikingly, pretreatment of ITF3056 starting at 0.1 mg kg significantly reduces the circulating TNFα by nearly 90%. To achieve a significant increase in serum IL-1β production, a higher dose of LPS is injected (10 mg kg), and blood is collected after 4 h. Similarly, when pretreated with lower doses of Givinostat (ITF-2357) (1 or 5 mg kg), there is a 22% reduction for 1 mg kg and 40% for 5 mg kg[1]. [1]. Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78. [2]. Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39. [3]. Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15.
    • ¥ 447
    5日内发货
    规格
    数量
  • HIF-PHD-IN-1
    T390401567657-46-8
    HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.
      5日内发货
      询价
    • MK-8617
      MK8617
      T41061187990-87-9
      MK-8617 是一种口服具有活力的低氧诱导因子脯氨酰羟化酶 1-3 (HIF PHD1-3) 泛抑制剂,对于PHD2的IC50=1 nM。
      • ¥ 169
      In stock
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    • TP0463518
      T53921558021-37-6
      TP0463518 是缺氧诱导因子脯氨酰羟化酶抑制剂,能够作用于人 PHD2(Ki= 5.3 nM)。它还抑制人PHD1 PHD3,IC50分别为 18 和 63 nM,以及猴 PHD2(IC50=22 nM)。
      • ¥ 593
      In stock
      规格
      数量
    • phd2/hdacs-in-1
      T622982339867-53-5
      PHD2 HDACs-IN-1 是一种有效的 PHD2 HDACs 混合抑制剂,能够作用于 PHD2 (IC50: 1.15 μM)、HDAC1 (IC50: 19.75 μM)、HDAC2 (IC50: 26.60 μM)、HDAC16 (IC50: 15.98 μM)。PHD2 HDACs-IN-1 是一种低毒性肾保护剂,能够用于顺铂诱导的急性肾损伤 (AKI) 的研究。
      • ¥ 10600
      8-10周
      规格
      数量
    • H-D-2-Pal-OH
      T6705337535-52-7
      H-D-2-Pal-OH 是一种氨基酸衍生物,在生命科学相关研究中具有广泛的应用。
      • 待询
      5日内发货
      规格
      数量
    • IOX4
      T78801154097-71-8
      IOX4 是选择性 PHD2抑制剂,IC50=1.6 nM,在细胞和野生型小鼠中诱导 HIFα表达,可透过血脑屏障。它与 PHD2 特性位点的 2-氧代戊二酸竞争并置换。
      • ¥ 123
      In stock
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      数量
    • PHD2-IN-1
      T792412768219-28-7
      PHD2-IN-1 为一种口服活性强效 HIF-脯氨酰羟化酶2 (PHD2) 抑制剂,具有 22.53 nM 的 IC50 值,适用于贫血病研究。
      • ¥ 10600
      8-10周
      规格
      数量
    • PhD2
      T81495
      PhD2是一种源自猴血白细胞的抗菌肽,对细菌与(真菌)Candida albicans显示出抗生活性。
      • 待询
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    • FHD-286
      T97492671128-05-3
      FHD-286 是 BRM BRG1 ATPase 的抑制剂,可用于治疗 BAF 相关疾病如急性髓性白血病的研究。
      • ¥ 1480
      In stock
      规格
      数量
      TargetMol | Inhibitor Sale
    • β-Defensin-1 (human) (trifluoroacetate salt)
      T35426
      β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but not of resistantM. tuberculosisRM22 when used at a concentration of 128 μg/ml.3,4It blocks human and mouse Kv1.3 voltage-gated potassium channels (IC50s = 11.8 and 13.2 μM, respectively).5Overexpression of β-defensin-1 in the human oral squamous cell carcinoma (OSCC) cell lines HSC-3, UM-1, and SCC-9 increases migration and invasion but not proliferation.6 1.Lehrer, R.I.Primate defensinsNat. Rev. Microbiol.2(9)727-738(2004) 2.Schroeder, B.O., Ehmann, D., Precht, J.C., et al.Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptideMucosal Immunol.8(3)661-671(2015) 3.Ouhara, K., Komatsuzawa, H., Yamada, S., et al.Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cellsJ. Antimicrob. Chemother.55(6)888-896(2005) 4.Fattorini, L., Gennaro, R., Zanetti, M., et al.In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosisPeptides25(7)1075-1077(2004) 5.Feng, J., Xie, Z., Yang, W., et al.Human beta-defensin 1, a new animal toxin-like blocker of potassium channelToxicon113(2016) 6.Han, Q., Wang, R., Sun, C., et al.Human beta-defensin-1 suppresses tumor migration and invasion and is an independent predictor for survival of oral squamous cell carcinoma patientsPLoS One9(3)e91867(2014)
      • 待估
      35日内发货
      规格
      数量
    • mHTT-IN-2
      T797172743336-70-9
      mHTT-IN-2(化合物27)作为mHTT的一种有效抑制剂,具有EC50值为0.066 μM,能够降低HTT RNA外显子[49-50]的规范剪接,从而调节HTT基因的剪接。在人类HD干细胞和BACHD小鼠模型上,mHTT-IN-2已显示出明显的体外及体内活性。此外,该化合物也被应用于研究与branaplam相关的周围神经病变。
      • 待估
      35日内发货
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      数量