amylin receptor

AC 187 Acetate 是胰淀素受体的强效拮抗剂。AC 187 对胰淀素受体的选择性高于降钙素和 CGRP 受体。

Amylin, amide, rat acetate(124447-81-0,free base) 是 AMY1 和 AMY3 受体以及 AMY2 受体的强效和高亲和力配体。

cAC 253 acetate (TP2135 Free base) 是 amylin 的拮抗剂，抑制 125I-adrenomedullin 结合，其IC50 值为 25 nM。

AC 187 TFA 是一种有效且具有口服活性的胰淀素受体 (amylin receptor) 拮抗剂，IC50为 0.48 nM，Ki 为 0.275 nM。AC 187 TFA 对胰淀素受体的选择性高于降钙素和 CGRP 受体。AC 187 TFA 具有神经保护作用。

Calcitonin (8-32), salmon, is a highly selective amylin receptor antagonist. Calcitonin, a hormone involved in calcium and phosphorus metabolism, is primarily produced by the parafollicular or C cells in the thyroid gland of mammals.

Eloralintide sodium(LY-3841136 sodium)是一种AMYR(amylin receptor)激动剂，可用于研究2型糖尿病和肥胖症。

Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the absence of insulin and is a key pathological feature of type II diabetes mellitus.

Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.

Pramlintide TFA，一种人类淀粉样肽类似物，主要作为抗糖尿病药物使用，并可用于肠癌研究。

Amylin, amide, human TFA 是一种含有37个氨基酸的胰腺多肽，与胰岛素共同分泌，对代谢和维持葡萄糖稳态具有重要作用。该化合物能够抑制胰高血糖素的分泌，延缓胃排空速度，同时作为增加饱腹感的因子。

Amylin (IAPP), feline TFA，一种来自猫科动物、含37个氨基酸的多肽，为胰岛β细胞的主要分泌物之一。作为调节肽，它能够抑制胰岛素和胰高血糖素的分泌。

Amylin (8-37) (human) (hIAPP (8-37))，为人类胰岛淀粉样多肽(IAPP)第8至第37位氨基酸片段。该片段在组装过程中形成带有发夹结构的双重折叠构型。

Amylin (1-37), human acetate(hIAPP (1-37), acetate)是由胰腺与胰岛素共同分泌的一种含有37个氨基酸的肽激素，在葡萄糖稳态中抑制胰高血糖素分泌和产生饱腹感，是2型糖尿病患者胰腺中淀粉样蛋白沉积的主要成分。

Acetyl-Amylin (8-37) (human) 是特异性的 amylin 拮抗剂。

Amylin, amide, human是一种由37个氨基酸组成的多肽激素，与胰岛素共分泌，参与调节餐后血糖水平,通过抑制胰高血糖素分泌、延缓胃排空等方式降低血糖。DAP Amylin在溶液中不稳定，易聚集形成淀粉样纤维，与2型糖尿病的胰岛β细胞损伤密切相关。

Amylin is a peptide that displays 50% homology with calcitonin gene-related peptide (CGRP), Amylin is colocalized with somatostatin in endocrine cells of the gastric fundus. In isolated mouse stomach, amylin caused a concentration-dependent decrease in ac

Amylin (8-37), rat, is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Also known as islet amyloid precursor peptide (IAPP), Amylin is co-secreted with insulin.

Amylin (IAPP), feline is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.

Pramlintide acetate是人源淀粉样肽的多肽类似物。作为一种抗糖尿病药物，它在结直肠癌中展现出抗肿瘤活性。

Eloralintide (LY 3841136) 是一种 AMYR 激动剂，预计将应用于 2 型糖尿病和肥胖症的研究。

Petrelintide (ZP8396) acetate 是一种 amylin 类似物，显示出能够降低体重的潜力，并可应用于糖尿病研究。

Colulintide 是胰淀素 (amylin) 的功能类似物，可用于研究肥胖症。

Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer's disease.

Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC50 = 0.166 nM). Salmon calcitonin inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID50 = 0.003 pg mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED15 = 33.9 mg kg). Formulations containing salmon calcitonin have been used to treat hypercalcemia, bone destruction by osteoporosis, and Paget's disease.