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S2157

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  • 抑制剂&激动剂
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    TargetMol | Inhibitors_Agonists
  • S2157
    S2157
    T397992262488-39-9
    S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound triggers apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by inhibiting NOTCH3 and TAL1 gene expression. Moreover, S2157 is capable of crossing the blood-brain barrier, effectively eliminating central nervous system (CNS) leukemia in mice models implanted with T-ALL cells.
    • ¥ 3770
    5日内发货
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  • Taladegib
    LY2940680
    T26661258861-20-9
    Taladegib (LY2940680) 是smoothened 受体拮抗剂。
    • ¥ 226
    In stock
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    TargetMol | Inhibitor Sale
  • MS21570
    5-(苄基硫代)-N-甲基-1,3,4-噻二唑-2-胺
    T582865373-29-7
    MS21570 作为 GPR171 拮抗剂基于其阻断能力,IC50 为 220 nM,可减少小鼠的焦虑样行为和恐惧条件反射。
    • ¥ 198
    In stock
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