SOST 重组蛋白, Human (His & Avi)

SOST Protein, Human, Recombinant (His & Avi)

产品编号 TMPK-00102 SOST Protein, Human, Recombinant (His & Avi)

SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. SOST Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.2 kDa and the accession number is Q9BQB4-1.

SOST Protein, Human, Recombinant (His & Avi)

产品编号 TMPK-00102 SOST Protein, Human, Recombinant (His & Avi)

规格	价格	库存
100 μg	¥ 2,960	5日内发货
500 μg	¥ 11,800	5日内发货
1 mg	¥ 19,700	5日内发货

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SOST Protein, Human, Recombinant (His & Avi)产品问题解答

问请问 Vancomycin 给药小鼠的剂量和方式是怎么样的？

答万古霉素（Vancomycin）：静脉，口服、腹腔都有文献报道，文献参考有用到 50 mg/kg/day 这个给药剂量的；参考文献：Treatment of Clostridium difficile infection in mice with vancomycin alone is as effective as treatment with vancomycin and metronidazole in combination；Vitamin C reduces vancomycin-related nephrotoxicity through the inhibition of oxidative stress, apoptosis, and inflammation in mice。

常见问题解答

问化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别？盐形式和游离态有什么区别？

答盐和非盐形式化合物的活性分子是一样的，在生物实验中起到的效果也一致，活性和使用方法都是一样的。只是由于呈盐不同，物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。

问如何选择某个靶点的特异性或总的抑制剂？特异性和非特异性的区别是什么？

答抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂，对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。一般评价一个抑制剂的抑制效率主要看 IC50 值，IC50 值越低，说明抑制剂效率越高。建议您根据以上几个特征进行综合选择，也可联系技术帮您推荐相关抑制剂。

产品信息

生物活性	Immobilized Human SOST, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 6.3ng/ml determined by ELISA.
产品描述	SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. SOST Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 24.2 kDa and the accession number is Q9BQB4-1.
种属	Human
表达系统	HEK293 Cells
标签	N-His-Avi
蛋白编号	Q9BQB4-1
别名	VBCHsclerosteosis,VBCH,SOST1,SOST,sclerostin,DAND6,CDD
蛋白构建	Gln24-Tyr213
蛋白纯度	> 95% as determined by Tris-Bis PAGE
分子量	24.2 kDa (predicted). Due to glycosylation,the protein migrates to 28-40 kDa based on Tris-Bis PAGE result.
内毒素	< 1 EU/μg by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

SOST Protein, Human, Recombinant (His & Avi)

SOST Protein, Human, Recombinant (His & Avi)

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