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Prednicarbate

Name: Prednicarbate
Brand: TargetMol
SKU: T21443
Price: 248 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.88%

货号 T21443Cas号 73771-04-7

别名 泼尼卡酯, UNII-V901LV1K7D, Hoe-777, Hoe 777, Dermatop E emollient

Prednicarbate (Hoe 777) 是一种外用皮质类固醇。Prednicarbate 可用于炎症性皮肤病的研究，如特应性皮炎。

Prednicarbate

一键复制产品信息

很棒

纯度: 99.88%

货号 T21443 别名 泼尼卡酯, UNII-V901LV1K7D, Hoe-777, Hoe 777, Dermatop E emollientCas号 73771-04-7

Prednicarbate (Hoe 777) 是一种外用皮质类固醇。Prednicarbate 可用于炎症性皮肤病的研究，如特应性皮炎。

规格	价格	库存
1 mg	¥ 248	现货
5 mg	¥ 558	现货
10 mg	¥ 845	现货
25 mg	¥ 1,180	现货
50 mg	¥ 1,650	现货
100 mg	¥ 2,480	现货
1 mL x 10 mM (in DMSO)	¥ 588	现货

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实验操作小课堂

常见问题解答

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纯度: 99.88%

颜色: 白色

性状: Solid

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COA LCMS HNMR 产品操作手册

产品介绍

Prednicarbate AI Summary

Prednicarbate exhibits a diverse range of bioactivities. Notably, it demonstrates a high potency in inhibiting Chronic Active B-Cell Receptor Signaling with a value of 5.2 nM and shows a potency of 58.0 nM in the Nrf2 screening assay, which is confirmed in the Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. Additionally, it inhibits the AmpC Beta-Lactamase enzyme with a potency of 79,432.8 nM in the presence of a detergent and HP1-beta Chromodomain interactions with methylated histone tails at 100,000.0 nM. Prednicarbate also acts as an inhibitor in the primary qHTS for delayed death of the malarial parasite plastid with a potency of 18,526.0 nM and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells both without and with CPT present, showing potencies of 16,066.6 nM and 12,762.2 nM, respectively. The compound has a bioactivity profile suggesting a low risk of drug-induced liver injury, with all measured Hepatic Side Effect (HepSE) scores in the DILIps training set reported as 0.0. This includes scores for bilirubinemia, cholecystitis, cirrhosis, hepatitis, and abnormal liver function tests among others, along with a combined HepSE score of 0.0, highlighting its low potential for hepatic side effects. In antiviral assays, Prednicarbate shows bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) with an inhibition index of 1.368, indicating higher activity than the arbidol control. However, its IC50 value in the inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells is greater than 20,000.0 nM, pointing to relatively low potency in this context. Additionally, Prednicarbate has high binding affinity (> 10,000.0 nM) towards various receptors such as human ADRB1, ADRB2, SLC6A3, OPRK1, ADORA1, ADRA1A, and others. It shows agonist activity at human OPRM1, HRH2, DRD1, PGR, HTR2A, and antagonist activity at CHRM2, HTR1A, ADRA2A, HTR2A, and HTR2B. It has a significant affinity for the human NR1I2 receptor with an AC50 value of 17.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Prednicarbate (Hoe 777) is a Corticosteroid Hormone Receptor Agonist. Prednicarbate has antipruritic, anti-inflammatory, and vasoconstrictive properties. It also decreases the number of circulating lymphocytes by inhibiting the production of vasodilators such as nitric oxide and prostacyclin.
别名	泼尼卡酯, UNII-V901LV1K7D, Hoe-777, Hoe 777, Dermatop E emollient

化学信息

分子量	488.57
分子式	C₂₇H₃₆O₈
CAS No.	73771-04-7
Smiles	C(COC(CC)=O)(=O)[C@]1(OC(OCC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])[H]
密度	1.25 g/cm3

储存&溶解度

存储

溶解度信息

H2O: Insoluble

DMSO: 10 mg/mL (20.47 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0468 mL	10.2339 mL	20.4679 mL	102.3395 mL
5 mM	0.4094 mL	2.0468 mL	4.0936 mL	20.4679 mL
10 mM	0.2047 mL	1.0234 mL	2.0468 mL	10.2339 mL
20 mM	0.1023 mL	0.5117 mL	1.0234 mL	5.1170 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Prednicarbate Corticosteroid Hormone Receptor

Prednicarbate

Prednicarbate

Prednicarbate 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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