nav1.1 activator 1

Nav1.1 activator 1 is a highly potent activator of Nav1.1 with BBB penetration.

Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 also increases the activity of Nav1.2 and Nav1.5 channels but not of Nav1.4, Nav1.6 and Nav1.7 channels. Lu AE98134 can be used to analyze pathophysiological functions of the Nav1.1 channel in various central nervous system diseases, including cognitive restoring in schizophrenia, et al[1].

Hm1a为一种具有多个二硫键的蜘蛛毒肽，兼作NaV1.1激活剂。在Dravet综合征(DS)小鼠模型中，Hm1a能够修复受损的抑制性中间神经元功能。

δ-Theraphotoxin-Hm1a毒素是一种针对Nav1.1通道的选择性激活剂，能够诱发疼痛反应和增强触觉敏感度，常用于研究肠易激综合征。