Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Devapamil (Devapamilo) 是一种苯烷基胺,以使用依赖性方式阻断来自膜细胞内侧的 L 型钙电流。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 560 | 现货 | ||
5 mg | ¥ 1,260 | 现货 | ||
10 mg | ¥ 1,850 | 现货 | ||
25 mg | ¥ 3,530 | 现货 | ||
50 mg | ¥ 4,790 | 现货 | ||
100 mg | ¥ 6,820 | 现货 | ||
500 mg | ¥ 13,700 | 现货 |
产品描述 | Devapamil (Devapamilo) is a phenylalkylamine that blocks L-type calcium currents from the inner side of membrane cells in a use-dependent manner. |
体外活性 | Devapamil (3 μM) reduced L-type calcium currents (ICa) to 16.1 +/- 8.6%, 11 +/- 8.9%, and 9.3 +/- 6% of control, respectively. Intracellular application of the same substances, via the patch pipette filled with 30 μM of devapamil, failed to depress ICa. The quaternary derivatives of the phenylalkylamines (30 microM) were ineffective both when applied extracellularly or intracellularly. It is suggested that phenylalkylamines block ICa in ventricular myocytes by acting on a binding site of the calcium channel molecule located at the outer surface of the cell membrane.[3] |
别名 | Devapamilo, Devapamilum |
分子量 | 424.58 |
分子式 | C26H36N2O3 |
CAS No. | 92302-55-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (117.76 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3553 mL | 11.7763 mL | 23.5527 mL | 58.8817 mL |
5 mM | 0.4711 mL | 2.3553 mL | 4.7105 mL | 11.7763 mL | |
10 mM | 0.2355 mL | 1.1776 mL | 2.3553 mL | 5.8882 mL | |
20 mM | 0.1178 mL | 0.5888 mL | 1.1776 mL | 2.9441 mL | |
50 mM | 0.0471 mL | 0.2355 mL | 0.4711 mL | 1.1776 mL | |
100 mM | 0.0236 mL | 0.1178 mL | 0.2355 mL | 0.5888 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Devapamil 92302-55-1 Membrane transporter/Ion channel Metabolism Calcium Channel Devapamilo Devapamilum Inhibitor inhibitor inhibit