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Anti-Sequestosome-1 Antibody (4X151)

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产品编号 TMAC-03710

别名 Ubiquitin-binding protein p62, SQSTM, Sequestosome-1, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, p60), OSIL, ORCA, EBI3-associated protein of 60 kDa(EBIAP

Anti-Sequestosome-1 Antibody (4X151) 是一种 Mouse 抗体，靶向 Sequestosome-1。Anti-Sequestosome-1 Antibody (4X151) 可用于 FCM,ICC，IHC。

Anti-Sequestosome-1 Antibody (4X151)

Anti-Sequestosome-1 Antibody (4X151)

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产品编号 TMAC-03710 别名 Ubiquitin-binding protein p62, SQSTM, Sequestosome-1, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, p60), OSIL, ORCA, EBI3-associated protein of 60 kDa(EBIAP

Anti-Sequestosome-1 Antibody (4X151) 是一种 Mouse 抗体，靶向 Sequestosome-1。Anti-Sequestosome-1 Antibody (4X151) 可用于 FCM,ICC，IHC。

规格价格库存数量
50 μL
¥ 1,990
5日内发货
100 μL
¥ 2,995
5日内发货
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产品介绍

生物活性
产品描述
Anti-Sequestosome-1 Antibody (4X151) is a Mouse antibody targeting Sequestosome-1. Anti-Sequestosome-1 Antibody (4X151) can be used in FCM,ICC，IHC.
别名Ubiquitin-binding protein p62, SQSTM, Sequestosome-1, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, p60), OSIL, ORCA, EBI3-associated protein of 60 kDa(EBIAP
克隆号
4X151
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of SQSTM1 on different cell lysates using anti-SQSTM1 antibody at 1/500 dilution. Positive control: Lane1: Hela, Lane2: HepG2.
2. Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-SQSTM1 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded mouse prostate tissue using anti-SQSTM1 antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue using anti-SQSTM1 antibody. Counter stained with hematoxylin.
5. ICC staining SQSTM1 in HepG2 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. Flow cytometric analysis of Hela?cells with SQSTM1 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Goat anti mouse IgG (FITC) was used as the secondary antibody.
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应用FCMICC，IHC
推荐剂量
WB: 1:500-1000; IHC: 1:200; ICC: 1:200; FCM: 1 μg per 1 x 106 cells
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Peptide affinity purified.
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck and independently found to interact with PKCζ. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-κB pathway. It may play a role in titin/TTN downstream signaling in muscle cells and regulate signaling cascades through ubiquitination. P62 may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
KLH conjugated synthetic peptide: within human SQSTM1 40-100 aa
抗原种属
human
Uniprot ID
Q13501
化学信息
分子量Theoretical: 62 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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