| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Tyloxapol 是一种烷基芳基聚醚醇型非离子液体聚合物,是一种表面活性稳定剂,可诱导动物高脂血症。
产品描述 | Tyloxapol is a non-ionic liquid polymer used as a surfactant. |
体外活性 | Tyloxapol is generally regarded as a safe stabilizer. In some studies, it is reported to causes cytotoxicity in epithelial and red blood cells, induces lysis of human Jurkat T-lymphoblasts and the apoptosis in RAW 264.7 murine macrophage-like cells and NIH/3T3 mouse fibroblast cells. These indications of cytotoxicity, however, do not reflect the in vivo use of Tyloxapol, since it is rarely used alone in clinical applications[3]. |
体内活性 | A single intravenous injection of tyloxapol at dose of 400 mg/kg body weight shows three distinctive phases, sharp linear increment, slow linear increment and slow decrement of plasma lipids toward the basal levels[1]. The treatment of tyloxapol enhannces the pulmonary absorption of rh-insulin and increases the absorption of inhaled insulin in diabetic rats. It might significantly increase the hypoglycemic effect of intratracheally administered insulin in diabetic rats but does not change the LDH activity[2]. |
细胞实验 | HEK293 cells growing at 40% confluency are exposed to different test dispersions of SLP or their individual components for 48 h and observed the alterations in cellular morphology.(Only for Reference) |
别名 | 四丁酚醇, Triton WR1339, 四丁酚醛 |
分子量 | N/A |
CAS No. | 25301-02-4 |
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
H2O: 25 mg/mL, Need ultrasonic
DMSO: 38 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
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您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tyloxapol 25301-02-4 GPCR/G Protein NF-Κb LPL Receptor NF-κB inhibit Triton WR 1339 Triton WR-1339 四丁酚醇 Triton WR1339 Inhibitor 四丁酚醛 inhibitor