keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SHU 9119 acetate 是众所周知的人黑皮质素 3 和 4 (hMC3R, hMC4R) 受体拮抗剂和部分 hMC5R 激动剂。人 MC3R、MC4R 和 MC5R 的 IC50 值分别为 0.23、0.06 和 0.09 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 957 | 现货 | ||
5 mg | ¥ 3,920 | 现货 | ||
10 mg | ¥ 5,590 | 现货 | ||
25 mg | ¥ 8,630 | 现货 | ||
50 mg | ¥ 11,600 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 6,450 | 现货 |
产品描述 | SHU 9119 acetate is a well-known antagonist of human melanocortin 3 and 4 (hMC3R, hMC4R) receptors and a partial hMC5R agonist. The IC50 values of human MC3R, MC4R and MC5R is 0.23, 0.06, and 0.09 nM respectively. |
靶点活性 | MC5R (human):0.09 nM, MC3R (human):0.23 nM, MC4R (human):0.06 nM |
体内活性 | Compared with control, blocking CNS-Mcr by chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) increases food intake in ad libitum-fed rats. Weight gain of SHU9119 treated rats is significantly higher than control. SHU9119 treatment effectively increases metabolic efficiency. SHU9119 markedly increases mRNA levels of genes promoting lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase. SHU9119 increases food intake (+30%) and body fat (+50%) and decreases EE by reduction in fat oxidation (?42%). Furthermore, SHU9119 impairs the uptake of VLDL-TG by BAT. In line with this, SHU9119 decreases uncoupling protein-1 levels in BAT (?60%) and induces large intracellular lipid droplets, indicative of severely disturbed BAT activity. |
别名 | SHU 9119 acetate (168482-23-3 free base) |
分子量 | 1134.29 |
分子式 | C56H75N15O11 |
CAS No. | T16879L |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (48.49 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.8816 mL | 4.408 mL | 8.8161 mL | 22.0402 mL |
5 mM | 0.1763 mL | 0.8816 mL | 1.7632 mL | 4.408 mL | |
10 mM | 0.0882 mL | 0.4408 mL | 0.8816 mL | 2.204 mL | |
20 mM | 0.0441 mL | 0.2204 mL | 0.4408 mL | 1.102 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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