Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Pyrvinium pamoate 是一种古老的驱虫药,用于治疗蛲虫病,由于其在某些类型的癌症中抑制 Wnt/β-catenin 通路,它作为抗癌药物再次引起人们的关注。
产品描述 | Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types of cancer. |
体外活性 | Pyrvinium pamoate treatment repressed the phosphorylation of GSK3β at S9 which might be mediated by AKT, and decreased the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). Pyrvinium pamoate remarkably inhibited cell viability and colony formation ability. Treatment with pyrvinium pamoate induced intrinsic pathway-dependent apoptosis accompanied with a decline of anti-apoptotic XIAP and Survivin, and an overt increase of pro-apoptotic Bax. In addition, pyrvinium pamoate significantly inhibited the migration and invasion in vitro[1]. |
别名 | 扑蛲灵, Pyrvinium embonate |
分子量 | 575.7 |
分子式 | C26H28N3 . 1/2 C23H14O6 |
CAS No. | 3546-41-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 12 mg/mL (20.84 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
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您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pyrvinium pamoate 3546-41-6 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin inhibit Pyrvinium Inhibitor 扑蛲灵 Pyrvinium embonate Wnt inhibitor