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Pyrroloquinoline quinone

Pyrroloquinoline quinone

产品编号 T5692   CAS 72909-34-3

Pyrroloquinoline quinone 是氧化还原辅助因子,一种阴离子型氧化还原循环原醌。它是哺乳动物的必需营养素,对免疫功能很重要。它是从嗜甲基细菌的培养物中分离的,也存在于哺乳动物的组织。

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Pyrroloquinoline quinone Chemical Structure
Pyrroloquinoline quinone, CAS 72909-34-3
规格 价格/CNY 货期 数量
100 mg ¥ 330 现货
其他形式的 Pyrroloquinoline quinone:
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
MG-132限时半价
产品目录号及名称: Pyrroloquinoline quinone (T5692)
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纯度: 98%
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参考文献
结构类型
产品描述 Pyrroloquinoline quinone (PQQ), as a well-known redox enzyme cofactor, PQQ can protect NS/PCs against glutamate toxicity associated with ROS-mediated mitochondrial pathway,
体外活性 Pyrroloquinoline quinone(PQQ) pretreatment showed its significant effect on protecting NS/PCs against glutamate-induced apoptosis/necrosis.?PQQ neuroprotection was associated with the decrease of intracellular reactive oxygen species (ROS) production, the increase of glutathione (GSH) levels, and the decrease of caspase-3 activity.?In addition, pretreatment with PQQ also significantly enhanced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in the NS/PCs exposed to glutamate[1].
体内活性 Pyrroloquinoline quinone(PQQ), a natural anti-oxidant present in a wide variety of human foods, exerted potent anti-fibrotic and ROS-scavenging activity in Balb/C mouse models of liver fibrosis. The antioxidant activity of PQQ was involved in the modulation of multiple steps during liver fibrogenesis, including chronic liver injury, hepatic inflammation, as well as activation of hepatic stellate cells and production of extracellular matrix. PQQ also suppressed the up-regulation of RACK1 in activated HSCs in vivo and in vitro. PQQ suppresses oxidative stress and liver fibrogenesis in mice[2].
动物实验 Healthy male Balb/C mice of 4–6 week were used to induce liver fibrosis and isolate primary HSCs.?The animals were obtained from SLAC Laboratory Animal Corp in SPF microbiological status.?All mice were maintained at 25°C with a 12 h dark/light cycle and completely randomly grouped.?For thioacetamide (TAA)-induced liver fibrosis, which has been shown to be closely resemble the panlobular and parenchymal fibrosis that is found in most human chronic liver disease , TAA was given by intraperitoneal injection ?at 200 mg/kg body weight 3 times each week for 8 weeks.?For bile duct ligation (BDL)-induced liver fibrosis, BDL was performed according to previous report , and mice were sacrificed 2 weeks later.?Administration of PQQ started on the second day when TAA was firstly given or BDL was performed, and PQQ was given at the dose of 0.3 mg/kg or 1 mg/kg by gastrogavage administration daily before mice were sacrificed.?Silymarin (150 mg/kg) was used as the positive control by gastrogavage administration daily.?Total number of 405 mice were used.?Mice were sacrificed by cervical dislocation under anesthesia[2].
分子量 330.21
分子式 C14H6N2O8
CAS No. 72909-34-3

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 2.75 mg/mL (8.33 mM), Sonification is recommended

H2O: 0.2 mg/mL (0.61 mM), Sonification is recommended

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0284 mL 15.1419 mL 30.2838 mL 75.7094 mL
5 mM 0.6057 mL 3.0284 mL 6.0568 mL 15.1419 mL

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TargetMol Library Books参考文献

1. Guan S , Xu J , Guo Y , et al. Pyrroloquinoline quinone against glutamate-induced neurotoxicity in cultured neural stem and progenitor cells[J]. International Journal of Developmental Neuroscience, 2015, 42:37-45. 2. Dongwei J , Fangfang D , Peike P , et al. Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice[J]. PLOS ONE, 2015, 10(3):e0121939-. 3. Saihara K, Kamikubo R, Ikemoto K,et al.Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway[J].Biochemistry. 2017 Dec 19;56(50):6615-6625.
L-Dihydroorotic acid γ-L-Glutamyl-L-alanine p-Cresyl sulfate potassium 3,5-Dihydroxybenzoic acid Xanthine meso-Erythritol (E)-m-Coumaric acid Biotin sulfone

相关化合物库

该产品包含在如下化合物库中:
微生物天然产物库 免疫/炎症分子化合物库 人内源代谢化合物库 Plus 人代谢物化合物库 已知活性化合物库 Ro5类药天然产物库 高通量筛选天然产物库 经典已知活性库 天然产物库

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请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

Pyrroloquinoline quinone 72909-34-3 Metabolism Others Endogenous Metabolite essential redox anionic inhibit Methoxatin co-factor PQQ bacteria function methylotropic immune nutrient Inhibitor inhibitor

 

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