Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) 是一种 G-四链体稳定剂,Kd 为 490 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 323 | 现货 | ||
2 mg | ¥ 460 | 现货 | ||
5 mg | ¥ 720 | 现货 | ||
10 mg | ¥ 1,100 | 现货 | ||
25 mg | ¥ 1,950 | 现货 | ||
50 mg | ¥ 2,960 | 现货 | ||
100 mg | ¥ 4,370 | 现货 |
产品描述 | Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) is a G-quadruplexe stabilizer, with a Kd of 490 nM. |
靶点活性 | G-quadruplexe:Kd:490 nM |
体外活性 | Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes |
细胞实验 | Cells are plated at equal confluence and either untreated or treated with 2 μM Pyridostatin continually for 72 h. Cells from individual plates are trypsinized and counted in a Coultercounter. Graphs represent total cell numbers at each time interval and error bars represent S.E.M. Data represent three independent experiments. |
别名 | Pyridostatin Trihydrochloride(free base 1085412-37-8 ), RR-82 Trihydrochloride |
分子量 | 706.02 |
分子式 | C31H35Cl3N8O5 |
CAS No. | T4457 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (70.82 mM)
H2O: 7.09mg/mL(10mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 1.4164 mL | 7.082 mL | 14.1639 mL | 35.4098 mL |
5 mM | 0.2833 mL | 1.4164 mL | 2.8328 mL | 7.082 mL | |
10 mM | 0.1416 mL | 0.7082 mL | 1.4164 mL | 3.541 mL | |
DMSO | 20 mM | 0.0708 mL | 0.3541 mL | 0.7082 mL | 1.7705 mL |
50 mM | 0.0283 mL | 0.1416 mL | 0.2833 mL | 0.7082 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pyridostatin Trihydrochloride T4457 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis RR 82 Trihydrochloride RR82 RR 82 Pyridostatin Trihydrochloride(free base 1085412-37-8 ) Pyridostatin RR-82 Trihydrochloride RR82 Trihydrochloride RR-82 Inhibitor inhibitor inhibit