Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Myricetin 是一种存在于常见植物中的类黄酮，具有强抗氧化，抗糖尿病，抗癌和抗炎活性。
| 产品描述 | Myricetin is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a rich dietary source. It has been shown that myricetin has antioxidant properties. |
| 靶点活性 | PI3Kγ:0.17 μM(Kd) |
| 体内活性 | Treatment of orthotopic pancreatic tumors with myricetin results in tumor regression and decreases metastatic spread[3]. |
| 细胞实验 | Pancreatic cancer cells (MIA PaCa-2, Panc-1 or S2-013) or normal pancreatic ductal cells (PDCs) are treated with myricetin (12.5–200 μM). Cell viability is determined using the Dojindo Cell Counting Kit-8. Cells are seeded onto a 96-well plate at 1×104 cells per well and allowed to adhere overnight. After treatment with myricetin at various concentrations for 24 hours, 10 μL of the tetrazolium substrate is added to each well of the plate. Plates are incubated at 37°C for 1 hour, after which the absorbance at 450 nm is measured[2]. |
| 别名 | Cannabiscetin, 杨梅素 |
| 分子量 | 318.24 |
| 分子式 | C15H10O8 |
| CAS No. | 529-44-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Ethanol: 20 mg/mL (62.84 mM), warmed
DMSO: 63 mg/mL (197.96 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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剂量换算对于不同动物的给药剂量换算，您也可以参考 更多...
体内实验配液计算器请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法： 比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)， 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300， 混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。
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您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。
Myricetin 529-44-2 Apoptosis Autophagy Metabolism PI3K/Akt/mTOR signaling PI3K Endogenous Metabolite Inhibitor inhibit Cannabiscetin 杨梅素 inhibitor
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