Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Lintitript是CCK1的选择性拮抗剂，对CCK1和CCK2的EC50s为6 nM和200 nM。对CCK1的Ki值为0.2 nM。
| 产品描述 | Lintitript is a selective antagonist of CCK1 with EC50s of 6 nM and 200 nM for CCK1 and CCK2. The Ki value is 0.2 nM for CCK1. |
| 靶点活性 | cholecystokinin CCK1 receptor:(ki)0.2 nM, CCK1:(EC50)6 nM |
| 体外活性 | Lintitript inhibited the CCK 2 site in guinea pig cortex with an IC2 of 479 nM. lintitript (0.5 nM) increased the dissociation constant of CCK on CCKA receptors with Kds between 1.8 and 7.2 nM without altering the maximum number of receptors. lintitript antagonized CCK-stimulated isolated rat pancreatic follicles in (amylase release and CCK-induced gallbladder contraction in guinea pigs with pA2s of 7.50 and 9.57). lintitript inhibited the binding of [125I]CCK to the rat pancreatic CCK1 receptor site with IC50 of 0.58 nM in a concentration-dependent manner[1]. |
| 体内活性 | Lintitript (1 mg/kg, i.v.) completely reversed CCK-induced amylase secretion. lintitript inhibited CCK-induced gastric and gallbladder emptying in mice with ED50s of 3 μg/kg and 72 μg/kg. lintitript (p.o.) was active in the gallbladder emptying protocol of egg yolk-induced endogenous CCK release, with an ED50 of 27 μg/kg [1]. |
| 别名 | SR 27897 |
| 分子量 | 411.86 |
| 分子式 | C20H14ClN3O3S |
| CAS No. | 136381-85-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 90 mg/mL (218.5 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
剂量换算对于不同动物的给药剂量换算，您也可以参考 更多
体内实验配液计算器计算器bottom
您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。
Lintitript 136381-85-6 GPCR/G Protein cholecystokinin SR 27897 林替曲特 Inhibitor inhibitor inhibit
沪公网安备 31010602006700号
