Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Avacopan (CCX168) 是一种口服小分子 C5aR (IC50: 0.1 nM.) 拮抗剂,可阻断 C5a 的作用并防止 AAV 小鼠模型中抗髓过氧化物酶抗体诱导的 GN 发展。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 429 | 待询 | ||
2 mg | ¥ 627 | 待询 | ||
5 mg | ¥ 987 | 待询 | ||
10 mg | ¥ 1,630 | 待询 | ||
25 mg | ¥ 3,280 | 待询 | ||
50 mg | ¥ 4,690 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,190 | 待询 |
产品描述 | Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a murine model of AAV. |
靶点活性 | C5aR:0.1 nM |
体内活性 | CCX168 (avacopan), an orally administered selective and potent C5aR inhibitor.?CCX168 blocked the C5a binding, C5a-mediated migration, calcium mobilization, and CD11b upregulation in U937 cells as well as in freshly isolated human neutrophils.?CCX168 retains high potency when present in human blood.?A transgenic human C5aR knock-in mouse model allowed comparison of the in vitro and in vivo efficacy of the molecule.?CCX168 effectively blocked migration in in vitro and ex vivo chemotaxis assays, and it blocked the C5a-mediated neutrophil vascular endothelial margination.?CCX168 was effective in migration and neutrophil margination assays in cynomolgus monkeys[1]. |
别名 | CCX168 |
分子量 | 581.64 |
分子式 | C33H35F4N3O2 |
CAS No. | 1346623-17-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (17.19 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7193 mL | 8.5964 mL | 17.1928 mL | 42.9819 mL |
5 mM | 0.3439 mL | 1.7193 mL | 3.4386 mL | 8.5964 mL | |
10 mM | 0.1719 mL | 0.8596 mL | 1.7193 mL | 4.2982 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Avacopan 1346623-17-3 Immunology/Inflammation Complement System CCX168 CCX-168 CCX 168 Inhibitor inhibitor inhibit