PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product Name	CAS No.	Purity
TQ0003L	740 Y-P(TFA)(1236188-16-1 free base) 化合物740 Y-P(TFA)	TQ0003L	98%
TQ0003L	740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) 是一种有效的细胞渗透性 PI3K 激活剂。
T72374	PI3K/mTOR Inhibitor-12 化合物 PI3K/mTOR Inhibitor-12	2891692-83-2	98%
T72374	PI3K/mTOR Inhibitor-12为口服有效且选择性的PI3K/mTOR抑制剂，对PI3Kα和mTOR的IC50分别为0.06 nM及3.12 nM，表现出抗肿瘤活性且肝毒性较低。
T72713	PI3K/VEGFR2-IN-1 化合物 PI3K/VEGFR2-IN-1	2851067-08-6	98%
T72713	PI3K/VEGFR2-IN-1是一种具有双重抑制效应的化合物，对PI3K和VEGFR2的IC50分别为2.21 μM和68 μM，能够诱导细胞凋亡(apoptosis)，在癌症研究中应用。
T12467	PI4KIII beta inhibitor 3 化合物 T12467	1245319-54-3	98%
T12467	PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).
T74782	CXJ-2 化合物 CXJ-2	2919976-92-2	98%
T74782	CXJ-2，一种环状肽，对EDP（弹性蛋白衍生肽）具中等亲和力。该化合物有效抑制PI3K/ERK通路，减少肝星状细胞的增殖与迁移，展现出显著的抗纤维化能力。
T11610	Idelalisib D5 化合物 T11610	1830330-31-8	98%
T11610	Idelalisib D5 is a deuterium-labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor.
TN5201	Uncarinic acid E 化合物 TN5201	277751-61-8	98%
TN5201	Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
T16908	Sonolisib 化合物 T16908	502632-66-8	98%
T16908	Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).
T12458	PI3K-IN-9 化合物 T12458	2360875-63-2	98%
T12458	PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).
T17066	Umbralisib hydrochloride 化合物 T17066	1532533-78-0	98%
T17066	Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε (E...
TN5050	Sprengerinin C 化合物 TN5050	88861-91-0	98%
TN5050	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
T10660L2	CAL-130 Racemate 化合物 T10660L2	474012-90-3	98%
T10660L2	CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
T77629	FD274 化合物FD274	2641899-38-7	98%
T77629	FD274 是一种高效的 PI3K/mTOR 双重抑制剂，对 PI3Kα/β/γ/δ 和 mTOR 具有抑制作用， IC50 分别为 0.65 nM、1.57 nM、0.65 nM、0.42 nM 和 2.03 nM。 FD274 在 AML 细胞系抗增殖实验中显示出显着的抗增殖活性。 FD274 在 HL-60 异种移...
T15800	LY117018 化合物 T15800	63676-25-5	98%
T15800	LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator.
T11818	LAS191954 化合物 T11818	1403947-26-1	98%
T11818	LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).
TN4213	Hirsutenone 化合物 TN4213	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
T3229	Cytochalasin D 细胞松弛素D	22144-77-0	98%
T3229	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertiliz...
TN3323	Monomethyl lithospermate 紫草酸单甲酯	933054-33-2	98%
TN3323	Monomethyl lithospermate (Lithospermic acid monomethyl ester) 具有潜在的抗病毒活性，通过激活PI5K/Akt信号传导，减轻体内大脑中动脉闭塞小鼠缺血性中风损伤，并在体外保护氧葡萄糖剥夺/复氧诱导的SHSY-3Y细胞。Monomethyl lithosperma...
TN3753	Dalbergioidin 化合物 TN3753	30368-42-4	98%
TN3753	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
TN1367	Alismol 化合物Alismol	87827-55-2	98%
TN1367	Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for ...