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Search Results for " vitronectin "

15

抑制剂 & 化合物

2

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T80859	Vitronectin
	Vitronectin为一类多功能糖蛋白，广泛分布于血液及细胞外基质。该蛋白质与糖胺聚糖、胶原蛋白、纤溶酶原及尿激酶受体发生结合，并对纤溶酶原激活抑制剂1的抑制构象起稳定作用。Vitronectin常用于促进伤口愈合和肿瘤进展研究领域。
T38603	Vitronectin (367-378)
	Vitronectin (367-378) is a peptide derived from residues 367-378 of the multifunctional glycoprotein known as Vitronectin. Vitronectin plays a pivotal role in cell growth, angiogenesis, and metastasis within various human tumors.
T2494	Cilengitide 西仑吉肽,EMD 121974	Integrin; Autophagy	Autophagy; Cytoskeletal Signaling
	Cilengitide (EMD 121974) 是一种有效的 αvβ3/5 受体整合素抑制剂，可抑制 ανβ3和 ανβ5与玻连蛋白结合，IC50值分别为 4 和 79 nM。
TP1879L1	P11 acetate	Integrin	Cytoskeletal Signaling
	P11 acetate 是一种整合素 αvβ3-玻连蛋白相互作用拮抗剂 (IC50 = 2.74 nM)。
TP1736L	Fibrinogen-Binding Peptide 137235-80-4(fb-acetate)	Others	Others
	Fibrinogen-Binding Peptide 137235-80-4(fb-acetate) 是纤维蛋白原受体上玻连蛋白结合位点的推定肽模拟物。它结合纤维蛋白原并抑制血小板与纤维蛋白原的粘附和血小板聚集，还抑制血小板与玻连蛋白的粘附
T76844	Abciximab C7E3	Integrin	Cytoskeletal Signaling
	Abciximab (C7E3) 是一种小鼠/人嵌合单克隆抗体，是一种有效的糖蛋白 IIb/IIIa (glycoprotein IIb/IIIa) 抑制剂。 Abciximab 具有抗血小板聚集和白细胞粘附的作用，通过与糖蛋白 IIb/IIIa、vitronectin 和 Mac-1 受体结合发挥作用。
T24796	SK&F 107260 Skf107260,Skf-107260,Skf 107260
	SK&F 107260 is an RGD-containing peptide. It is a potent GP IIb/IIIa antagonist and a vitronectin antagonist.
TP1736	Fibrinogen-Binding Peptide
	Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen, a soluble plasma protein, is a cofactor in platelet activation. It is converted
TP1879	HSDVHK-NH2 P11
	Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
T75835	HSDVHK-NH2 TFA
	HSDVHK-NH2 TFA 作为一种整合素 αvβ3-玻璃体结合蛋白的互作拮抗剂，其IC50值达到1.74 pg/mL (2.414 pM)。
T38363	MeOSuc-AAPV-pNA
	Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by b...
T82919	Batifiban TFA
	Batifiban TFA，环肽类血小板糖蛋白GPⅡb/Ⅲa拮抗剂，能有效抑制血小板聚集。通过阻断循环玻连蛋白与整合素 ανβ3 的结合，Batifiban 作用于血小板活化过程，减少血栓形成。
T70368	SF0166
	SF0166 是一种有效的选择性 αvβ3拮抗剂，对于 αvβ3，αvβ6，和 αvβ8的IC50值分别为 0.6 nM, 8 nM 和 13 nM。SF0166 抑制人、大鼠、兔和狗细胞系中玻连蛋白的细胞粘附，IC50值为 7.6 pM 至 76 nM。SF0166 在氧诱导视网膜病变小鼠模型中减少新生血管。
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。
T83736	RTDLDSLRTYTL TFA
	RTDLDSLRTYTL是一种αVβ6整合素配体。它选择性地抑制纤维连接蛋白与αVβ6整合素的结合，相比之下，对于纤维连接蛋白与αVβ3或αVβ5以及纤维蛋白原与αIIβ3的结合则几乎不产生影响（IC50分别为0.02, >50, >50, 和 >50 µM）。此外，RTDLDSLRTYTL还能以浓度依赖的方式抑制HT-29结肠癌细胞与纤维连接蛋白的结合。

化合物

Cat.No: T80859

Vitronectin (367-378)

Cat.No: T38603

Cat.No: T2494

Synonym: 西仑吉肽,EMD 121974

Target: Integrin, Autophagy

Cat.No: TP1879L1

Target: Integrin

Fibrinogen-Binding Peptide 137235-80-4(fb-acetate)

Cat.No: TP1736L

Target: Others

Cat.No: T76844

Synonym: C7E3

Target: Integrin

Cat.No: T24796

Synonym: Skf107260,Skf-107260,Skf 107260

Fibrinogen-Binding Peptide

Cat.No: TP1736

Cat.No: TP1879

Synonym: P11

Cat.No: T75835

MeOSuc-AAPV-pNA

Cat.No: T38363

Cat.No: T82919

Cat.No: T70368

Cat.No: T83848

RTDLDSLRTYTL TFA

Cat.No: T83736

Cat. No.	Product Name	Target	Signaling Pathways
T14347	Aureothricin	Antibacterial	Microbiology/Virology
	Aureothricin, a dithiolopyrrolone (DTP) antibiotic originally derived from Streptomyces, demonstrates a broad-spectrum of antibacterial effectiveness. Additionally, it inhibits the adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin[1].
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...

天然产物

Cat.No: T14347

Target: Antibacterial

Cat.No: TN5221

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00121	Vitronectin Protein, Human, Recombinant (His) V75,vitronectin,VN,VNT	Human	HEK293 Cells
	Vitronectin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is D9ZGG2.
TMPY-01861	Vitronectin Protein, Mouse, Recombinant (His) vitronectin,Vn,AI256434	Mouse	HEK293 Cells
	Vitronectin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.2 kDa and the accession number is P29788.
TMPJ-00472	Vitronectin Protein, Human, Recombinant (Truncated, His) Vitronectin,Complement S-protein,Serum Spreading Fa...	Human	HEK293 Cells
	Vitronectin, also known as VTN, is a large glycoprotein found in blood and the extracellular matrix (ECM). Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococca...
TMPY-05716	Integrin alpha V beta 3 Protein, Human, Recombinant (His) Integrin α V β 3,Integrin alpha V β3	Human	HEK293 Cells
	Integrin alpha-V & beta-3 (ITGAV/ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
TMPY-05717	Integrin alpha V beta 8 Protein, Human, Recombinant (His) Integrin alpha V β8,Integrin α V β 8	Human	HEK293 Cells
	Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This m...
TMPH-03598	Streptopain Protein, S. pyogenes serotype M28, Recombinant (His & SUMO)	Streptococcus pyogenes	E. coli
	Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Streptopain Protein, S. pyogenes serotype M28, Recombinant (His & SUMO) is expressed in E. coli expression system with...
TMPH-03599	Streptopain Protein, S. pyogenes, Recombinant (His & SUMO)	Streptococcus pyogenes	E. coli
	Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Streptopain Protein, S. pyogenes, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO...
TMPY-02759	Kallikrein 6/KLK6 Protein, Human, Recombinant (His) kallikrein-related peptidase 6,PRSS18,PRSS9,Klk7,Bssp,SP59,h...	Human	HEK293 Cells
	KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 sh...

重组蛋白

Vitronectin Protein, Human, Recombinant (His)

Cat.No: TMPY-00121

Species: Human

Expression System: HEK293 Cells

Vitronectin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01861

Species: Mouse

Expression System: HEK293 Cells

Vitronectin Protein, Human, Recombinant (Truncated, His)

Cat.No: TMPJ-00472

Species: Human

Expression System: HEK293 Cells

Integrin alpha V beta 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-05716

Species: Human

Expression System: HEK293 Cells

Integrin alpha V beta 8 Protein, Human, Recombinant (His)

Cat.No: TMPY-05717

Species: Human

Expression System: HEK293 Cells

Streptopain Protein, S. pyogenes serotype M28, Recombinant (His & SUMO)

Cat.No: TMPH-03598

Species: Streptococcus pyogenes

Expression System: E. coli

Streptopain Protein, S. pyogenes, Recombinant (His & SUMO)

Cat.No: TMPH-03599

Species: Streptococcus pyogenes

Expression System: E. coli

Kallikrein 6/KLK6 Protein, Human, Recombinant (His)

Cat.No: TMPY-02759

Species: Human

Expression System: HEK293 Cells

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