pneumoniae

TP0586532 是有效的non-hydroxamate LpxC 抑制剂 (IC50=0.101 μM)。TP0586532具有低心血管风险的特点，对肺炎克雷伯菌有效，包括耐药菌株。

Chlamydia pneumoniae-IN-1 是一种对衣原体有抑制作用的苯并咪唑类化合物，在低浓度下即可对肺炎衣原体产生抑制作用。Chlamydia pneumoniae-IN-1 具有抗菌活性，对CV-6菌株的 MIC 为12.6 μM，可用于研究肺部感染。

Blasticidin S HCl 是从 Streptomyces griseochromogenes 中分离的肽基核苷类抗生素 (antibiotic)，主要通过干扰核糖体中肽键的形成从而抑制原核细胞和真核细胞蛋白的合成。

Meropenem (SM 7338) 是一种具有广谱抗菌活性的碳青霉烯抗生素，对敏感和耐药的淋病奈瑟氏球菌，流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg mL，0.03-0.12 mg mL 和 0.015-0.12 mg mL。

Cefuroxime (Cephuroxime) 是一种具有口服活性的第二代头孢菌素类抗生素，具有抗菌活性，抑制革兰氏阳性菌和革兰氏阴性菌，可用于研究软组织感染。

PF-04753299 是一种有效的、选择性的LpxC 抑制剂。PF-04753299 对淋球菌分离株具有杀菌作用，对大肠杆菌、铜绿假单胞菌和肺炎菌株的抑制的MIC90值分别为 2 μg ml、4 μg ml 和 16 μg ml。PF-04753299 用于革兰氏阴性菌感染的研究。

α-(difluoromethyl)-DL-Arginine (RMI 71897) 是一种酶激活的、不可逆的大肠杆菌(Ki = 800 μM)、铜绿假单胞菌和肺炎克雷伯菌精氨酸脱羧酶抑制剂。在0.01 mM 时，它已被证明可以防止渗透胁迫诱导的燕麦叶片细胞精氨酸脱羧酶活性和腐胺合成的增加。当α-(difluoromethyl)-DL-Arginine 与多种多胺类似物联用时，能在10 mM 的最低浓度下抑制克氏锥虫在哺乳动物宿主细胞中的生长，并在T 细胞受体α缺陷小鼠模型中阻止小锥虫的生长。

LpxH-IN-AZ1 是一种有效的 UDP-2,3-二酰基葡糖胺焦磷酸水解酶LpxH 抑制剂，也是磺酰基哌嗪化合物。LpxH-IN-AZ1 具有抗菌活性，对肺炎克雷伯菌具有抑制作用，IC50 为 0.36 μM。

Delafloxacin (WQ-3034) 是一种广谱氟喹诺酮类抗生素，抑制耐药性的金黄色葡萄球菌，肺炎链球菌和肺炎克雷伯菌。

3,5-Dimethylbenzaldehyde 具有广谱的抗菌活性，对枯草芽孢杆菌、白假丝酵母菌、大肠杆菌、铜绿假单胞菌、金黄色葡萄杆菌和肺炎链球菌具有抑制作用。

Moxifloxacin (Avelox) 是一种8-甲氧基喹诺酮类口服有效抗菌药物，用于急性细菌性鼻窦炎，慢性支气管炎的急性细菌性加重和感染性肺炎的研究。

Colistin (Polymyxin E) 是一种具有口服活性的多肽类抗生素。它对包括多重耐药铜绿假单胞菌、鲍曼不动杆菌和肺炎克雷伯菌在内的多种革兰氏阴性杆菌表现出良好的抑制作用。此外，Colistin 与肾毒性相关，常用于研究革兰氏阴性菌感染。

CHEMBL1276927 (N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide) 对肺炎衣原体和多诺瓦尼利什曼原虫具有抗菌和抗寄生虫活性。

Debio-1452-NH3作为一种新型高效的FabI抗体—烯酰基载体蛋白还原酶抑制剂，在减轻小鼠体内细菌负担方面表现出色，并能有效救治因临床分离株的铜绿假单胞菌（Acinetobacter baumannii）、肺炎克雷伯菌（Klebsiella pneumoniae）及大肠杆菌（E. coli）引起的致命感染。

MLEB-22043为合成铁载体-单环β-内酰胺偶联物，其通过TonB依赖型转运蛋白的机制被细菌摄取。一旦进入细菌体内，该化合物通过其β-内酰胺组分展现出抑制细菌活性。作为一种广谱抗生素，MLEB-22043对包括Klebsiella pneumoniae、Escherichia coli、Acinetobacter baumannii及Pseudomonas aeruginosa在内的多种细菌显示出显著的抗菌效果。

CSP1 is a highly potent and selective agonist of the ComD1 receptor, exhibiting an IC50 value of 10.3 nM. It represents a major variant of competence-stimulating peptide (CSP) and plays a crucial role in regulating the genetic transformation of S. pneumoniae through modulation of quorum sensing (QS). Additionally, CSP1 possesses antibacterial activity, further enhancing its potential as an effective antibacterial agent.

(-)-Mycousnine is a microbial metabolite and derivative of usnic acid originally isolated fromM. nawaethat has antibacterial and antifungal activities.1,2It is active against the Gram-positive bacteriaB. subtilis,K. rhizophila, andS. aureus(MICs = 4, 8, and 4 g ml, respectively) but not the Gram-negative bacteriaE. coli,S. typhimurium, andK. pneumoniae(MICs = >128 g ml for all).2(-)-Mycousnine is also active against the fungiT. mentagrophytes,T. rubrum, andC. albicans(MICs = 25, 25, and 100 μg ml, respectively).1 1.Sassa, T., and Igarashi, M.Structures of (-)-mycousnine, (+)-isomycousnine and (+)-oxymycousnine, new usnic acid derivatives from phytopathogenic Mycosphaerella nawaeAgric. BioI. Chem.54(9)2231-2237(1990) 2.Lee, J., Lee, J., Kim, G.J., et al.Mycousfurans A and B, antibacterial usnic acid congeners from the fungus Mycosphaerella sp., isolated from a marine sedimentMar. Drugs17(7)422(2019)

Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50s = <0.09-1.78, 0.44-3.63, and 2.31-5.2 mg animal, respectively). Formulations containing cefazolin have been used to treat a variety of bacterial infections.

Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin .1 Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 μg ml, respectively.References1. Jones, R.N., and Packer, R.R. Cefotaxime, cephalothin, and cephapirin: Antimicrobial activity and synergy studies of cephalosporins with significant in vivo desacetyl metabolite concentrations. Diagn. Microbiol. Infect. Dis. 2(1), 65-68 (1984). Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin .1 Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 μg ml, respectively. References1. Jones, R.N., and Packer, R.R. Cefotaxime, cephalothin, and cephapirin: Antimicrobial activity and synergy studies of cephalosporins with significant in vivo desacetyl metabolite concentrations. Diagn. Microbiol. Infect. Dis. 2(1), 65-68 (1984).

TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks.

DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Notably, DS86760016 effectively inhibits LeuRS enzymes derived from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, exhibiting IC50 values of 0.38 μM, 0.62 μM, and 0.16 μM, respectively.

KPC-2-IN-2 (Compound 6c) 是一种有效的 Klebsiella pneumoniae carbapenemase 碳青霉烯酶 (KPC-2) 抑制剂 ，Ki 值为0.038 μM。KPC-2-IN-2 可以增强表达 KPC-2 的大肠杆菌中头孢噻肟的活性。

Ceftaroline fosamil hydrate acetate 是一种高效的头孢菌素类抗生素(antibiotic)，对多种病原体有广谱活性，特别是针对革兰氏阳性病原体，如耐甲氧西林金黄色葡萄球菌(MRSA)和耐多药肺炎链球菌，以及常见的革兰氏阴性微生物。此外，Ceftaroline fosamil hydrate acetate 在治疗复杂皮肤及皮肤结构感染(cSSSIs)和社区获得性肺炎(CABP)方面表现出显著的抗感染活性。

OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M. gallisepticum, M. pneumoniae, and S. aureus. OM173-αA also inhibits the growth of the plant pathogenic fungus P. oryzae and several species of Trichophyton.