plasma-proteins

N-Desmethyl-Apalutamide 是一种 Apalutamide 的活性代谢产物，主要由 CYP2C8 和 CYP3A4 介导形成。它是一种低活性的雄激素受体拮抗剂，其作用力是 Apalutamide 活性的三分之一。它是中等至强的CYP3A4和CYP2B6诱导剂，并具有优异的血浆蛋白结合浓度。

Ono-3307 mesylate 是一种蛋白酶抑制剂，对多种蛋白酶均具有抑制作用。Ono-3307 mesylate 对大鼠的肝损伤具有显着的保护作用，抑制放射性纤维蛋白在肾脏和肺部的沉积 ，可用于研究胰腺炎。

Cholesteryl linoleate 是低密度脂蛋白和动脉粥样硬化病变中主要的胆固醇酯。它存在于 LDL 中的胆固醇酯，利用 LDL 受体相关蛋白转移到表达 15-脂氧合酶的巨噬细胞和 CHO 细胞的质膜，被氧化形成胆固醇亚油酸氢过氧化物。

3-Chloro-L-Tyrosine (Chlorotyrosine) 是一种髓过氧化物酶催化氧化的特异性标志物，在从人动脉粥样硬化内膜分离的低密度脂蛋白中显著升高。

p-Cresol 是一种部分亲脂性成分，在正常条件下与血浆蛋白强烈结合。常用于杀菌剂及防霉剂的合成。

DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。

FKK6 是一种孕烷 X 受体 (PXR) 的选择性激动剂，EC50为 1.2 µM。它与血浆蛋白结合良好，且在人类微粒体中表现出良好的代谢特性。FKK6 抑制与 PXR 相关的NF-κB信号通路，减少炎症因子的表达，并在小鼠模型中对由 DSS 诱发的结肠炎展现出抗炎活性。

MBX-102 acid 是一种选择性部分PPAR-γ激动剂。它能高度结合血浆蛋白，主要与血清白蛋白结合，适用于二型糖尿病的研究。

Lp(a)-IN-5 (Compound A) 是一种口服活性的脂蛋白 (a) (Lp(a)) 抑制剂，通过抑制 Apo(a) 和 ApoB 蛋白的组装，IC50 值为 0.41 nM。它适用于研究与血浆 Lp(a) 水平升高相关的疾病，例如心血管疾病。

Halofenate 是一种用于抑制高甘油三酯血症的化合物，能够有效降低血清甘油三酯水平，而对血清胆固醇的影响甚微。此外，它可以降低血清尿酸，并通过与肾小球滤过率无关的机制促进尿酸排泄。Halofenate 还与血浆甲状腺素 (T4) 水平的显著增加有关，同时伴随蛋白结合碘和 T4 的减少，它能够从甲状腺结合蛋白中置换 T4，从而可能影响体内甲状腺功能。

Diazodiiodoarsenic acid was used to isolate plasma membrane proteins from platelets by means of affinity chromatography.

Iothalamate meglumine, known as radiopaque medium, can be used for urography, angiography, venography, and myelography. It is highly viscous and can bind to plasma proteins.

Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et al. Influence of dietary supplementation with fish oil on plasma fatty acid composition in coronary heart disease patients. Ann. Nutr. Metab. 39(1), 52-62 (1995).|2. Lee, J.Y., Sohn, K.H., Rhee, S.H., et al. Saturated fatty acids, but not unsaturated fatty acids, induced the expression of cyclooxygenase-2 mediated through toll-like receptor 4. J. Biol. Chem. 276(20), 16683-16689 (2001).|3. Dietzen, D.J., Hastings, W.R., and Lublin, D.M. Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae. J. Biol. Chem. 270(12), 6838-6842 (1995).|4. Robinson, L.J., and Michel, T. Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting. Proc. Nat. Acad. Sci. USA 92(25), 11776-11780 (1995).|5. Topinka, J.R., and Bredt, D.S. N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4. Neuron 20(1), 125-134 (1998).|6. Miggin, S.M., Lawler, O.A., and Kinsella, B.T. Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. J. Biol. Chem. 278(9), 6947-6958 (2003).

Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellular proteins, promotes protein-vesicle interactions, and regulates various G protein-coupled receptor functions.1Red blood cell palmitic acid levels are increased in patients with metabolic syndrome compared to patients without metabolic syndrome and are also increased in the plasma of patients with type 2 diabetes compared to individuals without diabetes.3,4 1.Fatima, S., Hu, X., Gong, R.-H., et al.Palmitic acid is an intracellular signaling molecule involved in disease developmentCell. Mol. Life Sci.76(13)2547-2557(2019) 2.Santos, M.J., López-Jurado, M., Llopis, J., et al.Influence of dietary supplementation with fish oil on plasma fatty acid composition in coronary heart disease patientsAnn. Nutr. Metab.39(1)52-62(1995) 3.Yi, L.-Z., He, J., Liang, Y.-Z., et al.Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDAFEBS Lett.580(30)6837-6845(2006) 4.Kabagambe, E.K., Tsai, M.Y., Hopkins, P.N., et al.Erythrocyte fatty acid composition and the metabolic syndrome: A National Heart, Lung, and Blood Institute GOLDN studyClin. Chem.54(1)154-162(2008)

Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.3,4,5,6,7

Phosphoramide mustard cyclohexanamine（磷酰胺氮芥环己胺盐）是cyclophosphamide的活性代谢物，是一种交联DNA链的烷基化剂，组织细胞分裂并导致细胞死亡，具有抗肿瘤活性。

Endosidin-2是一种囊外囊抑制剂,具有细胞渗透性的亚苄基苯甲酰肼，可与外囊复合体70 kDa（EXO70）亚基的外囊成分结合（Kd = 253 μM，EXO70A1）。Endosidin-2会破坏蛋白质在内质体和质膜之间的转运，从而促进蛋白质转运至液泡降解。它还能抑制 HeLa 细胞中内吞转铁蛋白向质膜的再循环，并能靶向哺乳动物 EXO70的多种异构体，导致外泌失调。Endosidin2 可作为工具分子研究胞吐。

CP-609754 是高效的、可逆的法尼基转移酶抑制剂，对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。

Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。

AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional relevance of this observation deserves to be investigated in vivo.

pTH-Related Protein (1-40) (human, mouse, rat) 促进大鼠肠细胞通过PTHR1受体和PKCα/β信号通路的钙吸收作用。该蛋白增加了甲状旁腺激素1受体（PTHR1）表达，提升了四种跨膜钙转运蛋白—TRPV6、CaBP-D9k、NCX1和PMCA1的水平。

Transferrins (Thypinone) 是负责运载由消化管吸收的铁和由红细胞降解释放的铁的蛋白质，主要存在于血浆中。Transferrins 具有抗菌杀菌活性，可促进胞外铁的储存和运输。

Perforin-IN-2, a benzosulfonamide perforin inhibitor, mitigates transplant rejection in allogeneic bone marrow or stem cell transplantation. It binds to plasma proteins with a binding rate of 99.8%. In vivo, a concentration higher than 900 μM is required for optimal perforin inhibition. Perforin-IN-2 effectively inhibits the lytic activity of recombinant perforin on Jurkat T leukemia cells, with an IC50 of 6.65 μM, and also prevents the death of K562 leukemia target cells [1].

thio-Miltefosine 作为膜组织中筏的调控剂,具有显著功能.筏是由多种脂质和蛋白质组成的纳米级聚集体,对细胞的功能产生深远影响.此外,thio-Miltefosine 可有效调节源自细胞的巨型质膜囊泡上的膜相行为.