gly arg amc (hydrochloride)

Gly-Arg-AMC is a fluorogenic substrate for cathepsin C.1 Upon enzymatic cleavage by cathepsin C, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin C activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. |1. Rubach, J.K., Cui, G., Schneck, J.L., et al. The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis. Biochemistry 51(38), 7551-7568 (2012).

Z-Gly-Pro-Arg-AMC hydrochloride是一种合成的多肽，常作为胰蛋白酶和组织蛋白酶K的荧光底物来测定酶的活性，当酶从肽上裂解时会发出荧光。