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Search Results for " fatty acid synthesis "

44

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11267	FASN-IN-1 TVB-2460	Fatty Acid Synthase	Metabolism
	FASN- in -1是一种有效的、特异性的脂肪酸合成酶(FASN)抑制剂，是一种专门设计用于靶向和抑制FASN 活性的化合物，是一种参与脂肪酸合成的酶，可抑制FASN 活性可以破坏脂肪酸的产生，并可能影响各种细胞过程。
T27460	GSK2324 GSK-2324,GSK 2324	FXR	Metabolism
	GSK2324 是一种有效的 FXR 激动剂，通过减少脂肪酸合成的吸收和选择性减少来控制肝脂质，可用于治疗非酒精性脂肪肝。
T9209	PF-05221304 STAT5 Inhibitor III,NSC 170984,R 6238,,Clesacostat	Acetyl-CoA Carboxylase	Metabolism
	PF-05221304 (NSC-170984) 是一种具有口服活性的肝脏靶向乙酰辅酶A 羧化酶 (ACC) 抑制剂，ACC 是脂肪酸合成的限速酶。
T4535	Etomoxir sodium salt (R)-(+)-乙莫克舍钠盐,(R)-Etomoxir sodium salt,Na salt,Etomoxir	Apoptosis; Others	Apoptosis; Others
	Etomoxir sodium salt ((R)-Etomoxir sodium salt) 是一种肉碱棕榈酰转移酶 1a (CPT-1a) 抑制剂，可以阻断脂肪酸合成。Etomoxir sodium salt 具有抗肿瘤活性。
T4309	CIL56 CA3	Ferroptosis; ROS	Apoptosis; Immunology/Inflammation
	CIL56 (CA3) 是一种选择性铁死亡诱导剂，可通过产生铁依赖性活性氧来诱导细胞铁死亡。
T17180	TVB-3166	Apoptosis; Others; Fatty Acid Synthase	Apoptosis; Metabolism; Others
	TVB-3166 是一种口服有效的，可逆和选择性脂肪酸合成酶 (FASN) 抑制剂，对于 FASN 和细胞棕榈酸酯合成的IC50分别为 42 nM 和 81 nM。它诱导细胞凋亡，抑制体内异种移植肿瘤生长。
T17181	TVB-3664	Fatty Acid Synthase	Metabolism
	TVB-3664 是一种具有口服具有活力的、选择性的、可逆的、具有高生物利用度的脂肪酸合酶抑制剂，其对人和老鼠棕榈酸酯合成的IC50分别为 18 nM 和 12 nM。可显著抑制微管蛋白棕榈酰化和 mRNA 表达。
T77513	2-Chlorophenylboronic acid	FAAH	Metabolism; Neuroscience
	2-Chlorophenylboronic acid 是一种单卤代苯硼酸，是一种重要的医药中间体，在新药合成中应用广泛。2-Chlorophenylboronic acid 对脂肪酸酰胺酶有抑制作用，Ki 值为0.01-1 µM，可用于研究抑郁症、青光眼、神经性疼痛、焦虑、偏头痛、I 型糖尿病和胃炎等疾病。
T1415	Gemfibrozil 吉非罗齐,CI-719,Jezil,Decrelip,Lopid	P450; Adrenergic Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Gemfibrozil (CI-719) 是一种PPAR-α激活剂，可作为降脂药。它也是P450非选择性抑制剂，对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。
T9495	Haloxyfop methyl ester	Others	Others
	Haloxyfop methyl ester 是一种选择性除草剂，脂肪酸合成抑制剂，具有内吸作用。茎叶经处理后，迅速被杂草吸收并传递至全株，水解成酸，抑制根、茎分生组织的生长，导致死亡。
T69461	Ro 20-0083
	Ro 20-0083 is an inhibitor of hepatic fatty acid synthesis.
T71948	Flufenacet
	Flufenacet is a herbicide, inhibiting very-long-chain fatty acid elongase (VLCFAE) synthesis.
T36120	3-hydroxy Tridecanoic Acid methyl ester
	3-hydroxy Tridecanoic acid methyl ester is a hydroxylated fatty acid methyl ester and major fatty acid component of A. lipolytica and A. glycerini. It has been used in the synthesis of components of the female sex pheromone of the painted apple moth (T. anartoides).
T71995	Decanoyl chloride
	Decanoyl Chloride is used in the synthesis of an effective metalloproteinase inhibitor. Also acts as a reagent in the synthesis of reversible α-ketoheterocycle inhibitors of fatty acid amide hydrolase as potnetial analgesics.
T27495	GSK951A
	GSK951A is an inhibitor of EchA6. GSK951A interacts with fatty acid synthase II (FAS-II), inhibits mycolic acid biosynthesis and suppresses the synthesis of all classes of MAMES in M. bovis BCG, whilst the FAMEs remain largely unaffected.
T40826	5(S)-HPETE
	5(S)-Hydroperoxyeicosatetraenoic acid (5(S)-HpETE) is a monohydroperoxy polyunsaturated fatty acid (PUFA) generated by the enzymatic conversion of arachidonic acid via 5-lipoxygenase (5-LO). Subsequently, 5(S)-HpETE undergoes metabolism to form leukotriene A4 (LTA4), which serves as a pivotal intermediate in the synthesis of leukotrienes (LTs).
T37408	Bischloroanthrabenzoxocinone
	Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics. Bischloroanthrabenzoxocinone (BABX) is an inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC50 values of 11.4 and 35.3 μg/ml, respectively. It inhibits the growth of S. aureus and permeable E. coli strains with minimum inhibitory concentrations ranging from 0.2-0.4 μg/ml. BABX also displays binding to liver X receptors (LXRs)...
T40782	Metazachlor
	Metazachlor, a member of the chloroacetamide class of herbicides, acts as a long chain fatty acid synthesis inhibitor. It exerts an influence on cell division and tissue differentiation in germinating and emerging weed species.
T37371	4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic Acid
	4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 . While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.
T35703	2-hydroxy Stearic Acid methyl ester
	2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides.
T23945	DA-11004 DA11004,UNII-48M66E9ER2
	DA-11004 is a potent NADP-dependent isocitrate dehydrogenase inhibitor (IC50: 1.49 μM for IDPc). DA-11004 inhibited fatty acid synthesis in adipose tissues via IDPc inhibition. It also decreased the plasma glucose levels and FFA in HF diet-induced obesity
T70499	Afabicin diolamine
	Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono, an enoyl-acyl carrier protein reductase (FabI) inhibitor, and is a first-in-class antibiotic with a novel mode of action to specifically target fatty acid synthesis in Staphylococcus spp.
T35691	Myristoyl Coenzyme A (hydrate)
	Myristoyl coenzyme A (myristoyl-CoA) is a derivative of CoA that contains the long-chain fatty acid myristic acid . It is a substrate for N-myristoyltransferase during myristoylation, a process that adds a myristoyl group to proteins either during translation to modify protein activity or post-translationally in apoptotic cells. It is also a substrate in the de novo synthesis of phosphatidylinositol .
T69350	Ethionamide HCl
	Ethionamide HCl is the salt form of Ethionamide, a second-line antitubercular agent that inhibits mycolic acid synthesis. Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unknown, it may inhibit the synthesis of mycolic acid, a saturated fatty acid found in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. This eventually leads to bacterial cell wall disruption and ...
T38473	Malonyl Coenzyme A lithium
	Malonyl Coenzyme A (lithium) is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl Coenzyme A (lithium) is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl Coenzyme A (lithium) is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
T35634	Platensimycin
	Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic ...
T38208	Heneicosapentaenoic Acid
	Heneicosapentaenoic Acid (HPA) is a 21:5 ω-3 fatty acid present in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the δ6 position. HPA can be used to study the significance of the position of the double bonds in ω-3 fatty acids. It incorporates into phospholipids and into triacylglycerol in vivo with the same efficiency as EPA and...
T70978	5-Hydroxy Lansoprazole Sulfide
	5-Hydroxy Lansoprazole Sulfide is an inhibitor of fatty acid synthase (FASN). FASN, which is responsible for de-novo synthesis of lipids, has been found to be overexpressed in cancerous tissue. 5-Hydroxy Lansoprazole Sulfide specifically inhibits enoyl reductase, and was found to more effectively inhibit FASN function than lansoprazole and was also more efficient at regulating NHEJ repair of oxidative DNA damage via PARP1.
T38222	N-(α-Linolenoyl) Tyrosine
	Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precurs...
T75292	Biotin sodium
	Biotin (Vitamin B7) sodium 是一种水溶性维生素 B，是人体五种羧化酶的辅酶，参与脂肪酸、异亮氨酸和缬氨酸的合成，并参与糖异生。Biotin sodium 是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢的必需物质。
T37785	1-Palmitoyl-2-linoleoyl PE
	Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE (PLPE) is one of the many phosphatidylethanolamines that may be present in cellular membranes. It has been used in studies involving the biosynthesis of anandamide via the phospholipase A2 (PLA2) and lysoPLD pathways. PLPE can also be used as a specific substrate to assess the activity of sPLA2-IIA in the presence of other phospholipids.
T15378	Gemcitabine elaidate Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126	Apoptosis; Nucleoside Antimetabolite/Analog; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Gemcitabine elaidate (CP-4126) 是 Gemcitabine 的亲脂性前药。它通过酯酶转化为 Gemcitabine 以被磷酸化。它具有抗肿瘤活性。
T35943	15(S)-HpETE
	15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 [1] or reduced to 15(S)-HETE by peroxidases.[2] [1] 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1. [3] 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inac...
T36634	ZQ 16
	Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro. Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579 PMID:27326330 \|Zhang et al (2016) Discovery and characte...
T78387	5-Dodecanoylaminofluorescein
	5-Dodecanoylaminofluorescein为亲脂性荧光探针，属于游离脂肪酸的荧光素衍生物。该探针应用于膜流动性分析与洗涤剂临界胶束浓度测定，并可用于制备药物递送用的疏水性纳米球。
T38125	Platencin
	Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including ...
T81319	Quizalofop-P	Acetyl-CoA Carboxylase	Metabolism
	Quizalofop-P被杂草通过茎叶吸收，能在植株内实现向上和向下的双向运输，并在顶端和分生区域累积，通过抑制脂肪酸合成，进而导致杂草死亡。此外，Quizalofop-P对禾本科杂草与双子叶作物具有显著的选择性。
T80060	Pyruvate carboxylase	Endogenous Metabolite	Metabolism
	Pyruvate carboxylase是一种催化反应中丙酮酸与HCO3−和MgATP进行依赖性羧化生成草酰乙酸的含生物素酶。它在调控肝脏糖异生、脂肪细胞脂肪酸合成及胰腺β细胞胰岛素分泌方面，对全身能量平衡发挥关键作用。
T37969	12(S)-HpETE
	12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and e...
T37691	Phosphatidic Acids (egg) (ammonium salt)
	Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis. It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple routes, including the glycerol-3 phosphate and dihydroxyacetone phosphate pathways, enzymatic conversion of phosphatidylcholine by phospholipase D, and acetylation of lysophosphatidic acid by lysoPA-acyltransferase, among others. It has roles in shaping cellular membranes, cellular ...
T37488	10(S),17(S)-DiHDHA
	Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stere...
T36130	22(S)-hydroxy Cholesterol 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
	22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22...
T36218	19R(20S)-EpDPA
	19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid .1,2It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.219R(20S)-EpDPA (30 nM) prevents calcium-induced increases in the spontaneous beating of isolated neonatal rat cardiomyocytes (NRCMs).3 1.Cinelli, M.A., Yang, J., Scharmen, A., et al.Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acidsJ. Lipid Res.59(11)2237-2252(2018) 2.Lucas...
T36608	(±)8-HEPE
	(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 8(S)-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.[1][2] Reference：[1]. Shing, T.K.M., Gibson, K.H., Wiley, J.R., et al. First total synthesis of a barnacle hatching factor 8(R)-hydroxy-eicosa-5(Z),9(E),11(Z)-pentaenoic acid. Tetrahedron Letters 35, 1067-1070 (1994).[2]. Hill, E...

化合物

Cat.No: T11267

Synonym: TVB-2460

Target: Fatty Acid Synthase

Cat.No: T27460

Synonym: GSK-2324,GSK 2324

Target: FXR

Cat.No: T9209

Synonym: STAT5 Inhibitor III,NSC 170984,R 6238,,Clesacostat

Target: Acetyl-CoA Carboxylase

Etomoxir sodium salt

Cat.No: T4535

Synonym: (R)-(+)-乙莫克舍钠盐,(R)-Etomoxir sodium salt,Na salt,Etomoxir

Target: Apoptosis, Others

Cat.No: T4309

Synonym: CA3

Target: Ferroptosis, ROS

Cat.No: T17180

Target: Apoptosis, Others, Fatty Acid Synthase

Cat.No: T17181

Target: Fatty Acid Synthase

2-Chlorophenylboronic acid

Cat.No: T77513

Target: FAAH

Cat.No: T1415

Synonym: 吉非罗齐,CI-719,Jezil,Decrelip,Lopid

Target: P450, Adrenergic Receptor, PPAR

Haloxyfop methyl ester

Cat.No: T9495

Target: Others

Cat.No: T69461

Cat.No: T71948

3-hydroxy Tridecanoic Acid methyl ester

Cat.No: T36120

Decanoyl chloride

Cat.No: T71995

Cat.No: T27495

Cat.No: T40826

Bischloroanthrabenzoxocinone

Cat.No: T37408

Cat.No: T40782

4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic Acid

Cat.No: T37371

2-hydroxy Stearic Acid methyl ester

Cat.No: T35703

Cat.No: T23945

Synonym: DA11004,UNII-48M66E9ER2

Afabicin diolamine

Cat.No: T70499

Myristoyl Coenzyme A (hydrate)

Cat.No: T35691

Ethionamide HCl

Cat.No: T69350

Malonyl Coenzyme A lithium

Cat.No: T38473

Cat.No: T35634

Heneicosapentaenoic Acid

Cat.No: T38208

5-Hydroxy Lansoprazole Sulfide

Cat.No: T70978

N-(α-Linolenoyl) Tyrosine

Cat.No: T38222

Cat.No: T75292

1-Palmitoyl-2-linoleoyl PE

Cat.No: T37785

Gemcitabine elaidate

Cat.No: T15378

Synonym: Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Autophagy

Cat.No: T35943

Cat.No: T36634

5-Dodecanoylaminofluorescein

Cat.No: T78387

Cat.No: T38125

Cat.No: T81319

Target: Acetyl-CoA Carboxylase

Pyruvate carboxylase

Cat.No: T80060

Target: Endogenous Metabolite

Cat.No: T37969

Phosphatidic Acids (egg) (ammonium salt)

Cat.No: T37691

10(S),17(S)-DiHDHA

Cat.No: T37488

22(S)-hydroxy Cholesterol

Cat.No: T36130

Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol

Cat.No: T36218

Cat.No: T36608

Cat. No.	Product Name	Target	Signaling Pathways
T7529	Yamogenin 山药	Others	Others
	Yamogenin 是一种薯蓣皂素的非对映异构体。它通过抑制 HepG2 肝细胞中脂肪酸合成的基因表达来抑制甘油三酸酯 (TG) 的积累。它在萤光素酶配体测定中拮抗肝脏 X 受体 (LXR) 的激活。
T13802	Oleamide Oleic acid amide	Others; Endogenous Metabolite	Metabolism; Others
	Oleamide (Oleic acid amide) 是一种内源性脂肪酸酰胺，可用于哺乳动物神经系统的从头合成。
TN7251	Olivetol Dimethyl Ether 1,3-dimethoxy-5-pentylbenzene	Others	Others
	Olivetol Dimethyl Ether 是一种单酰基甘油，具有镇痛活性和潜在的抗炎活性，可以抑制脂肪酸的合成。
T3P2904	α-Linolenic acid Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	α-Linolenic acid (Alpha-Linolenic Acid) 是一种必需脂肪酸，人体无法合成，从种子油中分离得到。它可调节 PI3K/Akt 信号传导，影响血栓形成过程。它具有抗心律失常的特性，并且与心血管疾病和癌症等有关。
T2S0164	Ethyl palmitate 棕榈酸乙酯,Palmitic acid ethyl ester,Ethyl cetylate,Ethyl hexadecanoate	Others	Others
	Ethyl palmitate (Palmitic acid ethyl ester) 是一种脂肪酸乙酯 (FAEE)。在人受试者食用酒精后，它的合成量比其他 FAEE 更多。它可用作头发和皮肤调理剂。
T11590	(-)-Hydroxycitric acid Garcinia acid,(-)-羟基柠檬酸	ATP Citrate Lyase	Metabolism
	(-)-Hydroxycitric acid (Garcinia acid) 是Garcinia cambogia 果皮中的主要酸。它是 ATP 柠檬酸裂解酶的竞争性抑制剂，能够抑制脂肪酸的合成，减少脂肪生成，控制食物摄入，从而减轻体重。
T0894	Thiamine hydrochloride 盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺（维生素B1）,Thiamine chloride hydrochloride	Apoptosis; HBV; Endogenous Metabolite	Apoptosis; Metabolism; Microbiology/Virology
	Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素，是许多中枢代谢酶的辅因子。
T4740	Elaidic acid 反油酸,trans-Oleic Acid	Endogenous Metabolite	Metabolism
	Elaidic acid (trans-Oleic Acid) 是在氢化植物油中发现的主要反式脂肪，能够被用作药物溶剂。在与花生四烯酸孵育的人类血小板中，反油酸抑制 HHT 和 HETE 的形成，同时诱导前列腺素和血栓素的合成。
T1165	Ethionamide Bayer 5312,乙硫异烟胺,2-ethylthioisonicotinamide,Ethinamide	Dehydrogenase; CAT; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology; oxidation-reduction
	Ethionamide (2-ethylthioisonicotinamide) 是一种抗结核抗生素。
T36831	9-Oxononanoic Acid 9-ONA	Phospholipase; CPT	Metabolism
	9-Oxononanoic Acid是一种氧化脂肪酸，由亚油酸自氧化形成，它能提高磷脂酶 A2（PLA2）的活性，并增加离体人体血浆中血栓素 B2 的生成。9-Oxononanoic Acid 能减少肝脏新脂肪酸的合成，并提高大鼠肝脏肉碱棕榈酰转移酶（β-氧化的标志物）的活性。
T4129	Arachidonic acid Immunocytophyte,花生四烯酸,arachidonate,Immunocytophyt,Vevodar	Others; Endogenous Metabolite	Metabolism; Others
	Arachidonic acid (Immunocytophyte) 是不饱和的必需脂肪酸。它存在于动物和人类脂肪以及肝脏、大脑和腺体器官中，是动物磷脂的成分。它由膳食亚油酸合成而成，是前列腺素、血栓素和白三烯生物合成的前体。
T6480	D-Pantothenic acid vitamin B5,pantothenate,D-泛酸	Others	Others
	D-Pantothenic acid (vitamin B5) 是必需的微量营养素，是辅酶 A 的前体，在很多生物过程中发挥关键作用，如调节碳水化合物，脂质，蛋白和核酸代谢。
T70955	Vinaxanthone SM-345431	Phospholipase; Antibacterial	Metabolism; Microbiology/Virology
	Vinaxanthone (SM-345431) 是一种从青霉菌中提取的小分子化合物，是一种具有选择性和有效性的 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂，抑制semaphorin3A 和 FabI。Vinaxanthone 具有抗菌活性，阻止细胞内脂肪酸合成，抑制金黄色葡萄球菌的生长。
T4947	3-Hydroxybutyric acid Butanoic acid,3-羟基丁酸	Endogenous Metabolite	Metabolism
	3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物，在 I 型糖尿病中升高。它能够调节膜脂的性质。
T11834	Leelamine hydrochloride	Others	Others
	Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabinoid receptor type 1 (CB1) agonist and suppresses SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, irrespective of androgen receptor status.
TN1751	Hydroxycitric acid	ERK; p38 MAPK; Fatty Acid Synthase	MAPK; Metabolism
	(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis.
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...

天然产物

Cat.No: T7529

Synonym: 山药

Target: Others

Cat.No: T13802

Synonym: Oleic acid amide

Target: Others, Endogenous Metabolite

Olivetol Dimethyl Ether

Cat.No: TN7251

Synonym: 1,3-dimethoxy-5-pentylbenzene

Target: Others

α-Linolenic acid

Cat.No: T3P2904

Synonym: Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸

Target: Akt, PI3K

Ethyl palmitate

Cat.No: T2S0164

Synonym: 棕榈酸乙酯,Palmitic acid ethyl ester,Ethyl cetylate,Ethyl hexadecanoate

Target: Others

(-)-Hydroxycitric acid

Cat.No: T11590

Synonym: Garcinia acid,(-)-羟基柠檬酸

Target: ATP Citrate Lyase

Thiamine hydrochloride

Cat.No: T0894

Synonym: 盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺（维生素B1）,Thiamine chloride hydrochloride

Target: Apoptosis, HBV, Endogenous Metabolite

Cat.No: T4740

Synonym: 反油酸,trans-Oleic Acid

Target: Endogenous Metabolite

Cat.No: T1165

Synonym: Bayer 5312,乙硫异烟胺,2-ethylthioisonicotinamide,Ethinamide

Target: Dehydrogenase, CAT, Antibacterial, Antibiotic

9-Oxononanoic Acid

Cat.No: T36831

Synonym: 9-ONA

Target: Phospholipase, CPT

Arachidonic acid

Cat.No: T4129

Synonym: Immunocytophyte,花生四烯酸,arachidonate,Immunocytophyt,Vevodar

Target: Others, Endogenous Metabolite

D-Pantothenic acid

Cat.No: T6480

Synonym: vitamin B5,pantothenate,D-泛酸

Target: Others

Cat.No: T70955

Synonym: SM-345431

Target: Phospholipase, Antibacterial

3-Hydroxybutyric acid

Cat.No: T4947

Synonym: Butanoic acid,3-羟基丁酸

Target: Endogenous Metabolite

Leelamine hydrochloride

Cat.No: T11834

Target: Others

Hydroxycitric acid

Cat.No: TN1751

Target: ERK, p38 MAPK, Fatty Acid Synthase

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

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