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TargetMol产品目录中 "

adenosine 3'-monophosphate

"的结果
  • 抑制剂&激动剂
    16
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    1
    TargetMol | Recombinant_Protein
  • 天然产物
    4
    TargetMol | Natural_Products
  • 同位素
    2
    TargetMol | Isotope_Products
  • Adenosine 3'-monophosphate (sodium salt hydrate)
    T35571
    Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine .
    • ¥ 443
    待询
    规格
    数量
  • Gizzerosine HCl
    Gizzerosine HCl(89238-78-8 Free base)
    T31931L103548-49-8In house
    Gizzerosine 2HCl是鱼粉热处理过程中产生的一种物质,可诱导的肉鸡雏鸡组织病理学病变,可提高离体鸡原产鸡的细胞内环腺苷-3',5'-单磷酸水平。
    • ¥ 2290
    In stock
    规格
    数量
  • Roflumilast
    罗氟司特, BYK 20869, BY 217, B9302-107, APTA 2217
    T1024162401-32-3
    Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4),具有抗炎和潜在的抗肿瘤活性,作用于PDE4A1,PDEA4,PDEB1和PDEB2,IC50分别为 0.7,0.9,0.7 和 0.2 nM。
    • ¥ 185
    In stock
    规格
    数量
  • Salbutamol
    Albuterol, AH-3365, 沙丁胺醇
    T113918559-94-9
    Salbutamol (Albuterol) 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病(COPD) 引发的支气管痉挛的研究。
    • ¥ 211
    In stock
    规格
    数量
  • Cyclic AMP
    腺苷环磷酸酯, 环磷腺苷, Cyclic 3',5'-monophosphate adenosine, cAMP, Adenosine Cyclophosphate, Adenosine 3',5'-cyclophosphate, 3',5'-AMP
    TCO274560-92-4
    Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使,可以促进 G1期到 S 期的细胞周期进程。
    • ¥ 198
    In stock
    规格
    数量
  • Adenosine-2'-monophosphate
    2'-AMP, AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-Adenylic acid
    T20054130-49-4
    Adenosine-2'-monophosphate (2'-AMP) 是由 2’,3'-CAMP 转化的核苷,抑制小胶质细胞产生炎性细胞因子,通过 A2A 受体抑制活化的原代小鼠小胶质细胞产生 TNF-α 和 CXCL10。
    • ¥ 279
    In stock
    规格
    数量
  • Trequinsin
    CHEMBL285913, 9,10-dimethoxy-3-methyl-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
    T20294879855-88-2
    Trequinsin HCl是一种依赖于环磷酸腺苷(cAMP)的磷酸二酯酶(PDE) 3抑制剂。它促进cAMP的积累并增加细胞膜电容。
    • 待询
    10-14周
    规格
    数量
  • Griseolic acid
    T2546379030-08-3
    Griseolic acid is a cyclic adenosine 3',5'-monophosphate phosphodiesterase II inhibitor.
    • ¥ 10600
    6-8周
    规格
    数量
  • Indimilast
    T321561038825-85-2
    Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Potential to treat chronic obst
    • ¥ 12800
    8-10周
    规格
    数量
  • Adenosine 5'-methylenediphosphate (hydrate)
    T35573
    Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) cells in a migration assay.2,3It increases tumor infiltration of CD3+CD8+T cells and reduces tumor growth in a K1735 murine melanoma model when administered at a dose of 400 μg mouse.4 1.Bruns, R.F.Adenosine receptor activation by adenine nucleotides requires conversion of the nucleotides to adenosineNaunyn Schmiedebergs Arch. Pharmacol.315(1)5-13(1980) 2.Braganhol, E., Tamajusuku, A.S.K., Bernardi, A., et al.Ecto-5′-nucleotidase CD73 inhibition by quercetin in the human U138MG glioma cell lineBiochim. Biophys. Acta1770(9)1352-1359(2007) 3.Shali, S., Yu, J., Zhang, X., et al.Ecto 5′ nucleotidase (CD73) is a potential target of hepatocellular carcinomaJ. Cell Physiol.234(7)10248-10259(2018) 4.Forte, G., Sorrentino, R., Montinaro, A., et al.Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanomaJ. Immunol.189(5)2226-2233(2021)
    • ¥ 1290
    35日内发货
    规格
    数量
  • pde1-in-4
    T63776
    PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂,能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 能够调控 cAMP (3′,5′- 环磷酸腺苷) 和 cGMP (3′,5′- 环磷酸鸟苷),表现出抗纤维化效果。PDE1-IN-4 能够抑制 TGF-β1 诱导的人肺成纤维细胞分化。PDE1-IN-4 能够用于研究特发性肺纤维化 (IPF)。
    • ¥ 10600
    10-14周
    规格
    数量
  • Cefminox sodium
    T65598
    Cefminox (Sodium) is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobic bacteria. Cefminox shows excellent in vivo efficacy (ED50) which is higher than would be expected from its in vitro activity (MIC). Moreover, cefminox possesses more potent activity in suppression of bacterial regrowth than other cephems[1]. Cefminox (Sodium) was the most active beta-lactam, with an MIC at which 50% of isolates are inhibited (MIC50) of 1.0 microg ml and an MIC90 of 16.0 microg ml. Cefminox was especially active against Bacteroides fragilis (MIC90, 2.0 microg ml), Bacteroides thetaiotaomicron (MIC90, 4.0 microg ml), fusobacteria (MIC90, 1.0 microg ml), peptostreptococci (MIC90, 2.0 microg ml), and clostridia, including Clostridium difficile (MIC90, 2.0 microg ml)[2]. The use of a single preoperative dose of cefminox was similar in efficacy to 3 doses of cefoxitin administered every 4 hours, and that the serum and tissue concentrations attained provide adequate antibiotic coverage[3]. Moreover, cefminox as a dual agonist of IP (Prostacyclin receptor) and PPARγ (peroxisome proliferator-activated receptor-gamma) that significantly inhibits PASMC proliferation by up-regulation of PTEN (phosphatase and tensin homolog) and cAMP ( cyclic adenosine monophosphate), suggesting that it has potential for treatment of PAH(pulmonary arterial hypertension)[4].
    • ¥ 1333
    5日内发货
    规格
    数量
  • Salbutamol-d9
    沙丁胺醇-d9
    TMID-02331173021-73-2
    Salbutamol-d9 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。
    • 待询
    35日内发货
    规格
    数量
  • Salbutamol-d3
    TMIH-05121219798-60-3
    Salbutamol-d3 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。
    • ¥ 2930
    5日内发货
    规格
    数量
  • Kushenol A
    苦参新醇 A, Leachianone E
    TN184199217-63-7
    Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
    • ¥ 5980
    5日内发货
    规格
    数量
  • Licoarylcoumarin
    TN4433125709-31-1
    Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.
    • ¥ 5420
    待询
    规格
    数量
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