44
3
13
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36685 |
TAF 10 Peptide
|
||
TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity. One vial of this peptide may be used as a methyltransferase acceptor peptide for more than 200 reactions at 15 μM. | |||
T2621 |
Rostafuroxin
PST 2238 |
ATPase; RSV | Membrane transporter/Ion channel; Microbiology/Virology |
Rostafuroxin (PST 2238) 是洋地黄毒苷衍生物,是一种口服有效的 Na+,K+-ATPase 抑制剂,具有抗高血压和抗 RSV 活性,用于研究治疗原发性高血压的试验。 | |||
T6349L |
Sitafloxacin
DU6859,DU 6859,DU 6859A,Sitafloxacin anhydrous,DU-6859,DU6859A,DU-6859A,西他沙星 |
||
Sitafloxacin, a new generation of broad-spectrum oral fluoroquinolones, is highly effective against many Gram-positive, Gram-negative, and anaerobic clinical isolates (including strains resistant to other fluoroquinolones). | |||
T6349 |
Sitafloxacin Hydrate
西他沙星水合物,DU-6859a,DU6859a hydrate |
Antibacterial; Antibiotic | Microbiology/Virology |
Sitafloxacin Hydrate (DU-6859a) 是一种口服有效的氟喹诺酮类抗生素,在体外可对抗广泛的革兰氏阳性和阴性细菌有活性。Sitafloxacin 可研究呼吸道感染和尿路感染。 | |||
T9646 |
Stafib-2
|
STAT | JAK/STAT signaling; Stem Cells |
Stafib-2 是一种转录因子 STAT5b 抑制剂,具有有效性和选择性。Stafib-2 对STAT5b 和 STAT5a 有抑制作用 , IC50 值分别为 82 nM 和 1.7 μM。Stafib-2 的细胞通透性较差。 | |||
T28911 |
Tafetinib
SIM-010603,SIM010603,SIM 010603 |
Tyrosine Kinases | Tyrosine Kinase/Adaptors |
Tafetinib (SIM-010603) 是一种新型有效且可口服的酪氨酸激酶抑制剂,具有抗血管生成和抗肿瘤活性。 | |||
T61699 |
Osunprotafib
AC 484,Osunprotafib,AC484,ABBV-CLS-484 |
Phosphatase | Metabolism |
ABBV-CLS-484 (Osunprotafib) 是一种具有亚纳摩尔活性的有效的PTPN2抑制剂,具有抗肿瘤活性,可增强T细胞抗肿瘤免疫力。ABBV-CLS-484可用于治疗肿瘤、食管癌和消化系统疾病。 | |||
T77135 |
Tafasitamab
MOR00208,XmAb5574,Tafasitamab-cxix |
Apoptosis; Immunology/Inflammation related | Apoptosis; Immunology/Inflammation |
Tafasitamab (XmAb5574) 是一种 Fc 修饰的人源化单克隆抗体,靶向人 B 细胞表面抗原 CD19 ,可用于研究弥漫性大B细胞淋巴瘤。 | |||
T4565 |
Tafamidis
他发米帝司甲葡胺,氯苯唑酸,Fx-1006A |
Others | Others |
Tafamidis (Fx-1006A) 是选择性的transthyretin (TTR)稳定剂,对野生型 WT-TTR 、突变型同源四聚体 V30M-TTR、V122I-TTR 的活性相当,它们的EC50值为2.7-3.2 μM。它对淀粉样蛋白的生成具有抑制作用。 | |||
T27335 |
Floctafenine
RU 15750,R-4318,R 4318,RU-15750,R4318 |
COX | Immunology/Inflammation; Neuroscience |
Floctafenine (R-4318) 是一种可口服的非甾体抗炎化合物,是 COX-I 和 COX-2 抑制剂,可干扰阿司匹林的抗血小板作用。Floctafenine 具有镇痛活性,可用于研究疼痛。 | |||
T16724 |
Razuprotafib
AKB-9778 |
Phosphatase; Others | Metabolism; Others |
Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂,抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外,它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化,增强 ANG1 诱导的 TIE2 活化,并刺激 TIE2 通路中信号分子的磷酸化。 | |||
T7182 |
Metaflumizone
BAS-320I,氰氟虫腙 |
Sodium Channel; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
Metaflumizone (BAS-320I) 是一种缩氨基脲杀虫剂,是钠离子通道阻滞剂。 | |||
T27122 |
Dasantafil
SCH446132,SCH-446132,SCH 446132 |
PDE | Metabolism |
Dasantafil (SCH446132) 是一种小分子磷酸二酯酶-5A(PDE5A)抑制剂,可用于治疗泌尿生殖系统疾病和研究勃起功能障碍。 | |||
T13083L |
Tafenoquine Succinate
他非诺喹琥珀酸盐,WR 238605 (Succinate) |
Others | Others |
Tafenoquine Succinate (WR 238605 (Succinate)),一种8-氨基喹啉类化合物,作用为抗疟疾预防剂。 | |||
T9339 |
Stafia-1
|
STAT | JAK/STAT signaling; Stem Cells |
Stafia-1 是STAT5a 抑制剂,Ki 为 10.9 μM,IC50 为 22.2 μM。它与 STAT5b 和其他 STAT 家族成员相比,显示出高选择性。 | |||
T7582 |
tafamidis meglumine
Fx-1006A,他发米帝司甲葡胺 |
Others | Others |
Tafamidis meglumine (Fx-1006A) 是transthyretin (TTR)的选择性稳定剂,对野生型 WT-TTR 和突变型同源四聚体 V30M-TTR,V122I-TTR 的活性相当,EC50值为 2.7-3.2 μM。它能够阻碍淀粉样蛋白的生成。 | |||
T66574 | sodium tetrakis (pentafluorophenyl)-borate | ||
sodium tetrakis (pentafluorophenyl)-borate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T66574。 | |||
T15243 |
Ertiprotafib
PTP 112 |
Phosphatase; PPAR | DNA Damage/DNA Repair; Metabolism |
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ). | |||
T79049 |
Tegeprotafib
PTPN2/1-IN-1 |
Phosphatase | Metabolism |
Tegeprotafib (PTPN2/1-IN-1) 是一种可口服活性PTPN1和PTPN2抑制剂,PTPN2的IC50为4.4 nM,PTPN1B的IC50介于1-10 nM之间。 | |||
T13083 |
Tafenoquine
他非诺喹,WR 238605 |
Others | Others |
Tafenoquine is an 8-aminoquinoline,and is an agent of anti-malarial prophylactic. | |||
T124921 |
Crotafoline
|
||
Crotafoline 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124921。 | |||
T28760 |
Setafrastat
|
||
Setafrastat is a vascular endothelial growth factor (VEGF) promotor and rotamase inhibitor. | |||
T19846 | Butafenacil | ||
Butafenacil is an effective anemia inducer. | |||
T76843 | Tebentafusp | ||
Tebentafusp (IMCgp100) 是靶向 gp100(一种黑色素瘤相关抗原)的双特异性融合蛋白。该药物通过其 T 细胞受体 (TCR) 高亲和力结合域以及抗 CD3 T 细胞接合域,指引 T 细胞针对表达 gp100 的肿瘤细胞进行杀伤。进一步,Tebentafusp 促进炎症细胞因子和细胞溶解酶的释放,直接导致肿瘤细胞裂解。 | |||
T75286 | Sitafloxacin hydrochloride | ||
Sitafloxacin (DU6859a) hydrochloride 是一款有效的口服活性氟喹诺酮类抗生素,它对广泛的革兰氏阳性细菌、革兰氏阴性细菌(包括厌氧菌)及非典型病原体都显示出抗菌活性。该化合物主要用于研究呼吸道感染和尿路感染。 | |||
T38256 |
Pentafluorobenzenesulfonyl fluorescein
|
Others | Others |
Pentafluorobenzenesulfonyl fluorescein 本身无荧光,但在磺酰基键被 H2O2 过水解时会发荧光。Pentafluorobenzenesulfonyl fluorescein 常被当作选择性 H2O2 传感器,可用于检测细胞中的 H2O2 含量。 | |||
T31685L |
Etafenone
LG-11457,LG 11457,LG11457,Etafenonum |
||
Etafenone is a vasodilator for the therapy of anigna pectoris. | |||
T31685 |
Etafenone HCl
NSC-166350,L.G. 11,457 hydrochloride,NSC166350,NSC 166350,Etafenone hydrochloride,Coronabason |
||
Etafenone HCl is a vasodilator. | |||
T28912 |
Tafluposide
F 11782,F-11782,F11782 |
||
Tafluposide is a DNA topoisomerase inhibitor with anti-tumor activity. | |||
T25090 |
Antafenite
R8193,R 8193,R-8193 |
||
Antafenite is an anthelminthic agent. | |||
T31684 |
Etafedrine HCl
Novedrin hydrochloride,Nethamine,Nethamine hydrochloride,Etafedrine hydrochloride,Menetyl,Novedrin |
||
Etafedrine HCl, named Nethaprin, is a long-acting bronchodilator. | |||
T37849 |
Butafosfan
|
||
Butafosfan is an organic phosphorus supplement that is given, most commonly with cyanocobalamin, to cattle, swine, horses, and poultry for the prevention or treatment of deficiencies. When given with cyanocobalamin, butafosfan alters lipid metabolism, serving to decrease the prevalence of subclinical ketosis. | |||
T37956 |
Tafluprost ethyl amide
|
||
Tafluprost ethyl amide 是一种前列腺素衍生物。Tafluprost ethyl amide 能降低眼压 (IOP),影响睫毛生长。Tafluprost ethyl amide 可用于抗青光眼眼药及化妆品。 | |||
T70150 |
Capstafin
|
||
Capstafin is a highly potent and selective inhibitor of STAT5b. | |||
T70149 |
PomCapstafin
|
||
PomCapstafin is a prodrug of Capstafin, acting as a potent, selective STAT5b inhibitor. | |||
T20142 |
Tafluprost acid
UNII-WTV8EPZ396 |
||
Tafluprost acid is a selective agonist at the prostaglandin F receptor. | |||
T73739 |
Pomstafib-2
|
||
Pomstafib-2 是一种有效的选择性 STAT5b 抑制剂。Pomstafib-2 降低 pSTAT5b 的表达并诱导细胞凋亡 (Apoptosis)。 | |||
T35917 |
Stafia-1-dipivaloyloxymethyl ester
|
||
Stafia-1-dipivaloyloxymethyl ester (compound 27) demonstrated a dose-dependent reduction in pSTAT5a expression (0-200 μM) while showing no discernible effect on pSTAT5b[1]. | |||
T124187 |
Euchrestaflavanone A
|
||
Euchrestaflavanone A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124187。 | |||
T126040 | Imbricataflavone A | ||
Imbricataflavone A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126040。 | |||
T24838 |
Stafib-1
Stafib 1,Stafib1 |
STAT | JAK/STAT signaling; Stem Cells |
Stafib-1 是一种特异性的 STAT5β 抑制剂,靶向 SH2 结构域,IC50 为 154 nM,Ki 为 44 nM。 | |||
T76974 | Tafolecimab | ||
Tafolecimab (IBI-306) 是一种人源 lgG2 单克隆抗体,可特异性结合 PCSK-9并通过抑制 PCSK-9 介导的低密度脂蛋白受体的内吞作用降低 LDL-C 水平,进而增强对 LDL-C 的清除,导致 LDL-C 水平降低。Tafolecimab 可用于高胆固醇血症的研究。 | |||
T75287 | Sitafloxacin monohydrate | ||
Sitafloxacin monohydrate (DU6859a) 是一种具有广谱的抗菌活性,并对多种革兰氏阳性和革兰氏阴性细菌(包括厌氧菌)以及非典型病原体有效的口服活性氟喹诺酮类抗生素。它主要用于研究呼吸道感染和尿路感染。 | |||
T72593 |
Antiviral agent 9
|
||
Antiviral agent 9 抗HIV-1的EC50达到皮摩尔浓度(0.006 nM), 与 tenofovir alafenamide fumarate(TAF)相比,选择性指数(SI)高近 300 倍。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0203 |
Tafluprost
MK2452,AFP-168,他氟前列素 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Tafluprost 是一种抗青光眼前列腺素(PG)类似物。 | |||
TN4028 |
Euchrestaflavanone B
|
PARP; Antifection | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of | |||
T26111 |
Robustaflavone
|
||
Robustaflavone is a naturally occurring biflavanoid isolated from Rhus succedanea and is a hepatitis B virus replication inhibitor. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02533 |
IGFBP-7 Protein, Human, Recombinant (aa 30-282, His)
insulin-like growth factor binding protein 7,PSF,IGFBP-7,FST... |
Human | HEK293 Cells |
IGFBP-7 Protein, Human, Recombinant (aa 30-282, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is Q16270. | |||
TMPY-02295 |
IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc)
IGFBP-7,IGFBPRP1,IBP-7,TAF,FSTL2,PSF,insulin-like g... |
Human | HEK293 Cells |
IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.5 kDa and the accession number is Q16270. | |||
TMPK-01027 |
IGFBP-7 Protein, Mouse, Recombinant (hFc)
TAF,RAMSVPS,IBP7,PSF,IGFBP-7,MAC25,IGFBPRP1,AGM,FST... |
Mouse | HEK293 Cells |
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Mouse, Recombinant (hFc) is expres... | |||
TMPK-01371 |
IGFBP-7 Protein, Human, Recombinant (hFc)
RAMSVPS,TAF,IGFBPRP1,AGM,IBP7,MAC25,IGFBP-7v,IGFBP-... |
Human | HEK293 Cells |
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Human, Recombinant (hFc) is expres... | |||
TMPY-06649 |
IGFBP-7 Protein, Human, Recombinant (His & Avi), Biotinylated
IGFBP-7v,IGFBP-7,MAC25,PSF,insulin-like growth factor bindin... |
Human | HEK293 Cells |
IGFBP-7 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 29.37 kDa and the accession number is Q16270. | |||
TMPJ-01166 |
IGFBP-7 Protein, Mouse, Recombinant (His)
TAF,IGFBP-rP1,Insulin-like growth factor-binding pr... |
Mouse | HEK293 Cells |
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of bloo... | |||
TMPY-06644 |
IGFBP-7 Protein, Human, Recombinant (hFc & Avi), Biotinylated
AGM,IGFBP-7,FSTL2,RAMSVPS,PSF,IGFBPRP1,IBP-7,MAC25,insulin-l... |
Human | HEK293 Cells |
IGFBP-7 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 54.98 kDa and the accession number is Q16270. | |||
TMPY-06848 |
IGFBP-7 Protein, Human, Recombinant (K95R, His)
PSF,MAC25,TAF,IBP-7,insulin-like growth factor bind... |
Human | HEK293 Cells |
IGFBP-7 Protein, Human, Recombinant (K95R, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.59 kDa and the accession number is Q16270. | |||
TMPY-02296 |
IGFBP-7 Protein, Human, Recombinant (aa 1-282, His)
TAF,IGFBP-7v,MAC25,IGFBP-7,FSTL2,PSF,IGFBPRP1,AGM,i... |
Human | HEK293 Cells |
IGFBP-7 Protein, Human, Recombinant (aa 1-282, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.9 kDa and the accession number is Q16270. | |||
TMPH-02175 |
TAF5L Protein, Human, Recombinant (GST)
|
Human | E. coli |
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. | |||
TMPJ-01279 |
TAFA4 Protein, Human, Recombinant (His)
FAM19A4,Protein FAM19A4,member A4,family with sequence simil... |
Human | E. coli |
FAM19A4 is a secreted, 12 kDa member of the FAM19/TAFA family of chemokine-like proteins. Like other members of the FAM19/TAFA family, with the exception of TAFA5, mature FAM19A4 contains 10 regularly spaced cysteine residues. The FAM19A4 proteins are predominantly expressed in specific regions of the brain and the biological functions of FAM19A4 family members remain to be determined, but there are a few tentative hypotheses. First, FAM19A4 may modulate immune responses in the CNS by functionin... | |||
TMPY-02946 |
TAFA2/FAM19A2 Protein, Human, Recombinant (hFc)
TAFA2,family with sequence similarity 19 (chemokine... |
Human | HEK293 Cells |
FAM19A2 belongs to the FAM19/TAFA family. FAM19/TAFA family members are chemokine-like proteins. The biological functions of TAFA family members remain to be determined, but there are a few tentative hypotheses. First, TAFAs may modulate immune responses in the CNS by functioning as brain specific chemokines, and may act with other chemokines to optimize the recruitment and activity of immune cells in the CNS. Second, TAFAs may represent a novel class of neurokines that act as regulators of immu... | |||
TMPH-02576 |
TAFA1/FAM19A1 Protein, Mouse, Recombinant (His & Myc)
|
Mouse | E. coli |
Regulatory factor which is ligand for CMKLR2 and is involved in the modulation of neural stem-cell proliferation and differentiation. |