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Targets Recommended: Others Guanylate cyclase

22

抑制剂 & 化合物

7

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16808	Runcaciguat	Others; Guanylate cyclase	GPCR/G Protein; Others
	Runcaciguat 是一种可溶性鸟苷酸环化酶刺激剂。 Runcaciguat 与特异性部分腺苷 A1 受体激动剂相结合，可用于心血管和肾脏疾病的研究。
T1984	Cinaciguat BAY 58-2667	Guanylate cyclase	GPCR/G Protein
	Cinaciguat (BAY 58-2667) 是一种不依赖于一氧化氮的鸟苷酸环化酶化剂，Kd 值为3.2 nM，可用于急性失代偿性心力衰竭的研究。
T4381	Lificiguat 利非西呱,YC-1	Others; Guanylate cyclase; HIF	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Others
	Lificiguat (YC-1) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶激活剂和低氧诱导因子 1α 的抑制剂。
T6968	Riociguat 利奥西呱,BAY 632521	Guanylate cyclase	GPCR/G Protein
	Riociguat (BAY 632521) 是一种鸟苷酸环化酶的刺激剂，可导致血管平滑肌松弛，用于治疗严重的肺动脉高压。
T16569	Praliciguat IW-1973	Others; Guanylate cyclase	GPCR/G Protein; Others
	Praliciguat (IW-1973) 是一种有效且具有口服活性的可溶性鸟苷酸环化酶 (sGC) 刺激剂，还增强 NO 信号传导，可作为血管扩张剂。在 HEK-293 细胞中，它能够刺激 sGC，EC50值为 197 nM。
T19023	Lucigenin NSC-151912,L-6868,光泽精	Others	Others
	Lucigenin (NSC-151912) 是化学发光探针，可用于检测内源性产生的超氧阴离子自由基在细胞的存在。
T19710	Ciglitazone Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis; p38 MAPK; PPAR	Apoptosis; DNA Damage/DNA Repair; MAPK; Metabolism
	Ciglitazone (ADD 3878) 是一种强效和选择性的PPARγ激动剂(EC50：3μM)和口服降糖药。Ciglitazone 抑制th17细胞的增殖和分化，降低胰岛素水平、血管内皮生长因子的产生和血压，诱导胃癌细胞的细胞周期停止。Ciglitazone 能诱导负鼠肾上皮细胞的凋亡，激活p38 MAPK 和凋亡诱导因子(AIF)的核转位。 Ciglitazone 在肥胖症和高血糖症的动物模型中表现出降血糖活性。
T7201	Nelociguat N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯,BAY60-4552	Guanylate cyclase	GPCR/G Protein
	Nelociguat (BAY60-4552) 是一种一氧化氮敏感的可溶性鸟苷酸环化酶刺激剂。
T21607	Ataciguat HMR-1766	Others; Guanylate cyclase	GPCR/G Protein; Others
	Ataciguat (HMR-1766) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 激活剂，具有血管舒张作用。它能够激活 sGC 的铁血红素铁氧化还原形式，刺激 cGMP 的产生。
T17226	Vericiguat 维利西呱,BAY1021189	Guanylate cyclase	GPCR/G Protein
	Vericiguat (BAY1021189) 是一种有效的口服鸟苷酸环化酶刺激剂。
T16383	Olinciguat IW-1701	Guanylate cyclase	GPCR/G Protein
	Olinciguat (IW-1701) 是一种口服鸟苷酸环化酶 (sGC) 刺激剂，在纯化的大鼠和人类酶测定以及全细胞测定中对 sGC 具有浓度依赖性刺激作用。
T32663	Leuciglumer Leuciglumero,Leuciglumere
	Leuciglumer is a bioactive chemical.
T27043	Clociguanil
	Clociguanil has antimalarial activity.
T1984L	Cinaciguat hydrochloride BAY582667,BAY58-2667,BAY 582667,BAY-582667,BAY 58-2667,BAY-58-2667,Cinaciguat HCl
	Cinaciguat( BAY582667, BAY58-2667) is a soluble guanosine cyclase activator that can prevent cardiac dysfunction in rat models of type 1 diabetes.
T39723	Mosliciguat
	Mosliciguat is a guanylate cyclase activator.
T33670	Nigrescigenin Canescegenine,Canescegenin,Sarmentosigenin A
	Nigrescigenin is a cardenolide from Parquetina nigrescens.
T125783	Crucigasterin 275

T125782	Crucigasterin 225

T39673	Zagociguat
	Zagociguat is a soluble guanylate cyclase stimulator that enhances nitric oxide (NO) signaling, resulting in increased production of cyclic guanosine monophosphate. This compound shows promise for investigating non-central nervous system (CNS) disorders.
T123930	Tenacigenoside A
	Tenacigenoside A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T123930。
T32928	Lucigenol
	Lucigenol is a bioactive chemical.
T125784	Crucigasterin 277

化合物

Cat.No: T16808

Target: Others, Guanylate cyclase

Cat.No: T1984

Synonym: BAY 58-2667

Target: Guanylate cyclase

Cat.No: T4381

Synonym: 利非西呱,YC-1

Target: Others, Guanylate cyclase, HIF

Cat.No: T6968

Synonym: 利奥西呱,BAY 632521

Target: Guanylate cyclase

Cat.No: T16569

Synonym: IW-1973

Target: Others, Guanylate cyclase

Cat.No: T19023

Synonym: NSC-151912,L-6868,光泽精

Target: Others

Cat.No: T19710

Synonym: Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878

Target: Apoptosis, p38 MAPK, PPAR

Cat.No: T7201

Synonym: N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯,BAY60-4552

Target: Guanylate cyclase

Cat.No: T21607

Synonym: HMR-1766

Target: Others, Guanylate cyclase

Cat.No: T17226

Synonym: 维利西呱,BAY1021189

Target: Guanylate cyclase

Cat.No: T16383

Synonym: IW-1701

Target: Guanylate cyclase

Cat.No: T32663

Synonym: Leuciglumero,Leuciglumere

Cat.No: T27043

Cinaciguat hydrochloride

Cat.No: T1984L

Synonym: BAY582667,BAY58-2667,BAY 582667,BAY-582667,BAY 58-2667,BAY-58-2667,Cinaciguat HCl

Cat.No: T39723

Cat.No: T33670

Synonym: Canescegenine,Canescegenin,Sarmentosigenin A

Crucigasterin 275

Cat.No: T125783

Crucigasterin 225

Cat.No: T125782

Cat.No: T39673

Tenacigenoside A

Cat.No: T123930

Cat.No: T32928

Crucigasterin 277

Cat.No: T125784

Cat. No.	Product Name	Target	Signaling Pathways
TN2206	Shancigusin I 4-(葡糖糖氧基)-肉桂酸葡萄糖氧基苄酯	Others	Others
	Shancigusin I 是来自 Cremastra appendiculata 块茎的天然产物。
TN2107	Protoescigenin	Others	Others
	Protoescigenin 来自七叶树皂甙混合物，可用作用于选择性保护的探索性化学的底物。
TN2577	11,12-Di-O-acetyltenacigenin B	Others	Others
	11,12-Di-O-acetyltenacigenin B 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2577，CAS号为 857897-01-9。
T2S1841	3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B 11-O-异丁酰基-12-O-乙酰基通关藤甘元B-3-O-茯苓二糖基,Tenacigenin B, 3-O-β-Allopyranosyl-(1→4),通关藤苷B	Others	Others
	Tenacigenin B, 3-O-β-Allopyranosyl-(1→4) 是植物茯苓Poria cocos 的成分之一。
TN6576	3-Methoxyshancigusin I
	3-Methoxyshancigusin I 可用于生命科学领域的相关研究，其产品编号为 TN6576。
TN2263	Tenacigenin B	P-gp	Membrane transporter/Ion channel; Neuroscience
	Tenacigenin B是一种天然产物，属于萝藦科牛奶菜属，其产品编号为 TN2263，CAS号为 80508-42-5。Tenacigenin B可用作对照参考。
T83459	11α-O-Tigloyl-12β-O-acetyltenacigenin B	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	11α-O-Tigloyl-12β-O-acetyltenacigenin B 是Tenacigenin B 的酯类衍生物，源自藤黄藤 (MTC)。该化合物具有调节Aurora-A活性，对淋巴瘤显示出潜在的抗肿瘤效果。

天然产物

Cat.No: TN2206

Synonym: 4-(葡糖糖氧基)-肉桂酸葡萄糖氧基苄酯

Target: Others

Cat.No: TN2107

Target: Others

11,12-Di-O-acetyltenacigenin B

Cat.No: TN2577

Target: Others

3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B

Cat.No: T2S1841

Synonym: 11-O-异丁酰基-12-O-乙酰基通关藤甘元B-3-O-茯苓二糖基,Tenacigenin B, 3-O-β-Allopyranosyl-(1→4),通关藤苷B

Target: Others

3-Methoxyshancigusin I

Cat.No: TN6576

Cat.No: TN2263

Target: P-gp

11α-O-Tigloyl-12β-O-acetyltenacigenin B

Cat.No: T83459

Target: Aurora Kinase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01430	NovoNectin Protein, Human, Recombinant NovoNectin,Cold-insoluble globulin,FN,CIG,Fibronect...	Human	E. coli
	Fibronectin1(FN1) is a secreted protein and contains 12 fibronectin type-I domains,fibronectin type-II domains and 16 fibronectin type-III domains.Recombinant human fibronectin fragment, is a protein of ~63 kDa containing a central cell-binding domain, a high affinity heparin-binding domain II,and CS1 site within the alternatively spliced III CS region of human fibronectin. Cells bind to a VLA-4 ligand, a CS-I site, and a VLA-5 ligand, a cell attachment domain, and virus vectors binds to a hepar...
TMPY-00803	Fibronectin Protein, Human, Recombinant (aa 607-1265, His) GFND,LETS,ED-B,fibronectin 1,CIG,GFND2,FNZ,FINC,FN,...	Human	HEK293 Cells
	Fibronectin Protein, Human, Recombinant (aa 607-1265, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.2 kDa and the accession number is P02751-15.
TMPY-05562	Fibronectin Protein, Human, Recombinant (aa 1722-1811, His) fibronectin 1,ED-B,CIG,FNZ,MSF,FN,FINC,GFND,LETS,GF...	Human	HEK293 Cells
	Fibronectin Protein, Human, Recombinant (aa 1722-1811, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.3 kDa and the accession number is P02751-15.
TMPK-01390	Fibronectin Protein, Human, Recombinant (aa 32-602, His) FNZ,ED-B,SMDCF,FN1,GFND,MSF,GFND2,LETS,FN,FINC,CIG	Human	HEK293 Cells
	Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 32-602, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted m...
TMPK-01391	Fibronectin Protein, Human, Recombinant (aa 1266-1356, His) FN1,LETS,GFND,MSF,FNZ,CIG,ED-B,FN,SMDCF,GFND2,FINC	Human	HEK293 Cells
	Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 1266-1356, His) is expressed in HEK293 mammalian cells with C-His tag. The predicte...
TMPK-01389	Fibronectin Protein, Human, Recombinant (aa 32-345, His) MSF,ED-B,LETS,SMDCF,FN,GFND2,CIG,FNZ,FN1,GFND,FINC	Human	HEK293 Cells
	Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 32-345, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted m...
TMPK-01373	Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc) FINC,LETS,GFND,SMDCF,GFND2,ED-B,MSF,FNZ,FN1,FN,CIG	Human	HEK293 Cells
	Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicte...

重组蛋白

NovoNectin Protein, Human, Recombinant

Cat.No: TMPJ-01430

Species: Human

Expression System: E. coli

Fibronectin Protein, Human, Recombinant (aa 607-1265, His)

Cat.No: TMPY-00803

Species: Human

Expression System: HEK293 Cells

Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)

Cat.No: TMPY-05562

Species: Human

Expression System: HEK293 Cells

Fibronectin Protein, Human, Recombinant (aa 32-602, His)

Cat.No: TMPK-01390

Species: Human

Expression System: HEK293 Cells

Fibronectin Protein, Human, Recombinant (aa 1266-1356, His)

Cat.No: TMPK-01391

Species: Human

Expression System: HEK293 Cells

Fibronectin Protein, Human, Recombinant (aa 32-345, His)

Cat.No: TMPK-01389

Species: Human

Expression System: HEK293 Cells

Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc)

Cat.No: TMPK-01373

Species: Human

Expression System: HEK293 Cells

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