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Targets Recommended: Others Guanylate cyclase

22

抑制剂 & 化合物

7

天然产物

7

重组蛋白

2

同位素

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Cat. No. Product Name Target Signaling Pathways
T16569 Praliciguat

IW-1973

Others; Guanylate cyclase GPCR/G Protein; Others
Praliciguat (IW-1973) 是一种有效且具有口服活性的可溶性鸟苷酸环化酶 (sGC) 刺激剂,还增强 NO 信号传导,可作为血管扩张剂。在 HEK-293 细胞中,它能够刺激 sGC,EC50值为 197 nM。
T16808 Runcaciguat

Others; Guanylate cyclase GPCR/G Protein; Others
Runcaciguat 是一种可溶性鸟苷酸环化酶刺激剂。 Runcaciguat 与特异性部分腺苷 A1 受体激动剂相结合,可用于心血管和肾脏疾病的研究。
T6968 Riociguat

利奥西呱,BAY 632521

Guanylate cyclase GPCR/G Protein
Riociguat (BAY 632521) 是一种鸟苷酸环化酶的刺激剂,可导致血管平滑肌松弛,用于治疗严重的肺动脉高压。
T4381 Lificiguat

利非西呱,YC-1

Others; Guanylate cyclase; HIF Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Others
Lificiguat (YC-1) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶激活剂和低氧诱导因子 1α 的抑制剂。
T1984 Cinaciguat

BAY 58-2667

Guanylate cyclase GPCR/G Protein
Cinaciguat (BAY 58-2667) 是一种不依赖于一氧化氮的鸟苷酸环化酶化剂,Kd 值为3.2 nM,可用于急性失代偿性心力衰竭的研究。
T19023 Lucigenin

NSC-151912,L-6868,光泽精

Others Others
Lucigenin (NSC-151912) 是化学发光探针,可用于检测内源性产生的超氧阴离子自由基在细胞的存在。
T7201 Nelociguat

N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯,BAY60-4552

Guanylate cyclase GPCR/G Protein
Nelociguat (BAY60-4552) 是一种一氧化氮敏感的可溶性鸟苷酸环化酶刺激剂。
T19710 Ciglitazone

Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878

Apoptosis; p38 MAPK; PPAR Apoptosis; DNA Damage/DNA Repair; MAPK; Metabolism
Ciglitazone (ADD 3878) 是一种强效和选择性的PPARγ激动剂(EC50:3μM)和口服降糖药。Ciglitazone 抑制th17细胞的增殖和分化,降低胰岛素水平、血管内皮生长因子的产生和血压,诱导胃癌细胞的细胞周期停止。Ciglitazone 能诱导负鼠肾上皮细胞的凋亡,激活p38 MAPK 和凋亡诱导因子(AIF)的核转位。 Ciglitazone 在肥胖症和高血糖症的动物模型中表现出降血糖活性。
T21607 Ataciguat

HMR-1766

Others; Guanylate cyclase GPCR/G Protein; Others
Ataciguat (HMR-1766) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 激活剂,具有血管舒张作用。它能够激活 sGC 的铁血红素铁氧化还原形式,刺激 cGMP 的产生。
T16383 Olinciguat

IW-1701

Guanylate cyclase GPCR/G Protein
Olinciguat (IW-1701) 是一种口服鸟苷酸环化酶 (sGC) 刺激剂,在纯化的大鼠和人类酶测定以及全细胞测定中对 sGC 具有浓度依赖性刺激作用。
T17226 Vericiguat

维利西呱,BAY1021189

Guanylate cyclase GPCR/G Protein
Vericiguat (BAY1021189) 是一种有效的口服鸟苷酸环化酶刺激剂。
T32663 Leuciglumer

Leuciglumero,Leuciglumere

Others Others
Leuciglumer is a bioactive chemical.
T27043 Clociguanil

Others Others
Clociguanil has antimalarial activity.
T1984L Cinaciguat hydrochloride

BAY582667,BAY58-2667,BAY 582667,BAY-582667,BAY 58-2667,BAY-58-2667,Cinaciguat HCl

Others Others
Cinaciguat( BAY582667, BAY58-2667) is a soluble guanosine cyclase activator that can prevent cardiac dysfunction in rat models of type 1 diabetes.
T125782 Crucigasterin 225

Others Others
T33670 Nigrescigenin

Canescegenine,Canescegenin,Sarmentosigenin A

Others Others
Nigrescigenin is a cardenolide from Parquetina nigrescens.
T39673 Zagociguat

Others Others
Zagociguat is a soluble guanylate cyclase stimulator that enhances nitric oxide (NO) signaling, resulting in increased production of cyclic guanosine monophosphate. This compound shows promise for investigating non-central nervous system (CNS) disorders.
T125783 Crucigasterin 275

Others Others
T39723 Mosliciguat

Others Others
Mosliciguat is a guanylate cyclase activator.
T125784 Crucigasterin 277

Others Others
T123930 Tenacigenoside A

Others Others
Tenacigenoside A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T123930。
T32928 Lucigenol

Others Others
Lucigenol is a bioactive chemical.

化合物

Praliciguat
Cat.No: T16569
Synonym: IW-1973
Target: Others, Guanylate cyclase
Runcaciguat
Cat.No: T16808
Synonym:
Target: Others, Guanylate cyclase
Riociguat
Cat.No: T6968
Synonym: 利奥西呱,BAY 632521
Target: Guanylate cyclase
Lificiguat
Cat.No: T4381
Synonym: 利非西呱,YC-1
Target: Others, Guanylate cyclase, HIF
Cinaciguat
Cat.No: T1984
Synonym: BAY 58-2667
Target: Guanylate cyclase
Lucigenin
Cat.No: T19023
Synonym: NSC-151912,L-6868,光泽精
Target: Others
Nelociguat
Cat.No: T7201
Synonym: N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯,BAY60-4552
Target: Guanylate cyclase
Ciglitazone
Cat.No: T19710
Synonym: Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878
Target: Apoptosis, p38 MAPK, PPAR
Ataciguat
Cat.No: T21607
Synonym: HMR-1766
Target: Others, Guanylate cyclase
Olinciguat
Cat.No: T16383
Synonym: IW-1701
Target: Guanylate cyclase
Vericiguat
Cat.No: T17226
Synonym: 维利西呱,BAY1021189
Target: Guanylate cyclase
Leuciglumer
Cat.No: T32663
Synonym: Leuciglumero,Leuciglumere
Target: Others
Clociguanil
Cat.No: T27043
Synonym:
Target: Others
Cinaciguat hydrochloride
Cat.No: T1984L
Synonym: BAY582667,BAY58-2667,BAY 582667,BAY-582667,BAY 58-2667,BAY-58-2667,Cinaciguat HCl
Target: Others
Crucigasterin 225
Cat.No: T125782
Synonym:
Target: Others
Nigrescigenin
Cat.No: T33670
Synonym: Canescegenine,Canescegenin,Sarmentosigenin A
Target: Others
Zagociguat
Cat.No: T39673
Synonym:
Target: Others
Crucigasterin 275
Cat.No: T125783
Synonym:
Target: Others
Mosliciguat
Cat.No: T39723
Synonym:
Target: Others
Crucigasterin 277
Cat.No: T125784
Synonym:
Target: Others
Tenacigenoside A
Cat.No: T123930
Synonym:
Target: Others
Lucigenol
Cat.No: T32928
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
TN2206 Shancigusin I

4-(葡糖糖氧基)-肉桂酸葡萄糖氧基苄酯

Others Others
Shancigusin I 是来自 Cremastra appendiculata 块茎的天然产物。
TN2107 Protoescigenin

Others Others
Protoescigenin 来自七叶树皂甙混合物,可用作用于选择性保护的探索性化学的底物。
TN2577 11,12-Di-O-acetyltenacigenin B

Others Others
11,12-Di-O-acetyltenacigenin B 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2577,CAS号为 857897-01-9。
T2S1841 3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B

11-O-异丁酰基-12-O-乙酰基通关藤甘元B-3-O-茯苓二糖基,Tenacigenin B, 3-O-β-Allopyranosyl-(1→4),通关藤苷B

Others Others
Tenacigenin B, 3-O-β-Allopyranosyl-(1→4) 是植物茯苓Poria cocos 的成分之一。
T83459 11α-O-Tigloyl-12β-O-acetyltenacigenin B

Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic
11α-O-Tigloyl-12β-O-acetyltenacigenin B 是Tenacigenin B 的酯类衍生物,源自藤黄藤 (MTC)。该化合物具有调节Aurora-A活性,对淋巴瘤显示出潜在的抗肿瘤效果。
TN2263 Tenacigenin B

P-gp Membrane transporter/Ion channel; Neuroscience
Tenacigenin B是一种天然产物,属于萝藦科牛奶菜属,其产品编号为 TN2263,CAS号为 80508-42-5。Tenacigenin B可用作对照参考。
TN6576 3-Methoxyshancigusin I

3-Methoxyshancigusin I 可用于生命科学领域的相关研究,其产品编号为 TN6576。

天然产物

Shancigusin I
Cat.No: TN2206
Synonym: 4-(葡糖糖氧基)-肉桂酸葡萄糖氧基苄酯
Target: Others
Protoescigenin
Cat.No: TN2107
Synonym:
Target: Others
11,12-Di-O-acetyltenacigenin B
Cat.No: TN2577
Synonym:
Target: Others
3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B
Cat.No: T2S1841
Synonym: 11-O-异丁酰基-12-O-乙酰基通关藤甘元B-3-O-茯苓二糖基,Tenacigenin B, 3-O-β-Allopyranosyl-(1→4),通关藤苷B
Target: Others
11α-O-Tigloyl-12β-O-acetyltenacigenin B
Cat.No: T83459
Synonym:
Target: Aurora Kinase
Tenacigenin B
Cat.No: TN2263
Synonym:
Target: P-gp
3-Methoxyshancigusin I
Cat.No: TN6576
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPJ-01430 NovoNectin Protein, Human, Recombinant

NovoNectin,Cold-insoluble globulin,FN,CIG,Fibronect...

Human E. coli
Fibronectin1(FN1) is a secreted protein and contains 12 fibronectin type-I domains,fibronectin type-II domains and 16 fibronectin type-III domains.Recombinant human fibronectin fragment, is a protein of ~63 kDa containing a central cell-binding domain, a high affinity heparin-binding domain II,and CS1 site within the alternatively spliced III CS region of human fibronectin. Cells bind to a VLA-4 ligand, a CS-I site, and a VLA-5 ligand, a cell attachment domain, and virus vectors binds to a hepar...
TMPY-00803 Fibronectin Protein, Human, Recombinant (aa 607-1265, His)

GFND,LETS,ED-B,fibronectin 1,CIG,GFND2,FNZ,FINC,FN,...

Human HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 607-1265, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.2 kDa and the accession number is P02751-15.
TMPY-05562 Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)

fibronectin 1,ED-B,CIG,FNZ,MSF,FN,FINC,GFND,LETS,GF...

Human HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 1722-1811, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.3 kDa and the accession number is P02751-15.
TMPK-01391 Fibronectin Protein, Human, Recombinant (aa 1266-1356, His)

FN1,LETS,GFND,MSF,FNZ,CIG,ED-B,FN,SMDCF,GFND2,FINC

Human HEK293 Cells
Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 1266-1356, His) is expressed in HEK293 mammalian cells with C-His tag. The predicte...
TMPK-01390 Fibronectin Protein, Human, Recombinant (aa 32-602, His)

FNZ,ED-B,SMDCF,FN1,GFND,MSF,GFND2,LETS,FN,FINC,CIG

Human HEK293 Cells
Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 32-602, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted m...
TMPK-01373 Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc)

FINC,LETS,GFND,SMDCF,GFND2,ED-B,MSF,FNZ,FN1,FN,CIG

Human HEK293 Cells
Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicte...
TMPK-01389 Fibronectin Protein, Human, Recombinant (aa 32-345, His)

MSF,ED-B,LETS,SMDCF,FN,GFND2,CIG,FNZ,FN1,GFND,FINC

Human HEK293 Cells
Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells to the surrounding extracellular matrix. Fibronectin has affinity to the other main components of extracellular matrix, collagen and glycosaminoglycans. Fibronectin Protein, Human, Recombinant (aa 32-345, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted m...

重组蛋白

NovoNectin Protein, Human, Recombinant
Cat.No: TMPJ-01430
Species: Human
Expression System: E. coli
Fibronectin Protein, Human, Recombinant (aa 607-1265, His)
Cat.No: TMPY-00803
Species: Human
Expression System: HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)
Cat.No: TMPY-05562
Species: Human
Expression System: HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 1266-1356, His)
Cat.No: TMPK-01391
Species: Human
Expression System: HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 32-602, His)
Cat.No: TMPK-01390
Species: Human
Expression System: HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc)
Cat.No: TMPK-01373
Species: Human
Expression System: HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 32-345, His)
Cat.No: TMPK-01389
Species: Human
Expression System: HEK293 Cells
Cat. No. Product Name Target Signaling Pathways
TMIH-0595 Vericiguat-d3

Vericiguat-d3 是 Vericiguat 的氘代化合物。Vericiguat 的 CAS 号为 1350653-20-1。Vericiguat 是一种有效的口服鸟苷酸环化酶刺激剂。
TMIH-0497 Riociguat-13C-d6

Riociguat-13C-d6 是 Riociguat 的 13C 和氘代化合物。Riociguat 的 CAS 号为 625115-55-1。Riociguat 是一种鸟苷酸环化酶的刺激剂,可导致血管平滑肌松弛,用于治疗严重的肺动脉高压。

同位素

Vericiguat-d3
Cat.No: TMIH-0595
Synonym:
Target:
Riociguat-13C-d6
Cat.No: TMIH-0497
Synonym:
Target:
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