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顶部生物活性储存和溶解信息计算器

Anti-EGFR Antibody (9H356)

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Anti-EGFR Antibody (9H356)
产品编号 TMAC-01251
别名 PIG61, NISBD2, mENA, LEGFR, HER1, ERBB1, ERBB, EGFR, EC 2.7.10.1, EC 2.7.10

Anti-EGFR Antibody (9H356) 是一种 Rabbit 抗体，靶向 EGFR。Anti-EGFR Antibody (9H356) 可用于 WB,ICC/IF,IHC,IP。

Anti-EGFR Antibody (9H356)

Anti-EGFR Antibody (9H356)

Rating icon 还可以
Anti-EGFR Antibody (9H356)
产品编号 TMAC-01251 别名 PIG61, NISBD2, mENA, LEGFR, HER1, ERBB1, ERBB, EGFR, EC 2.7.10.1, EC 2.7.10

Anti-EGFR Antibody (9H356) 是一种 Rabbit 抗体，靶向 EGFR。Anti-EGFR Antibody (9H356) 可用于 WB,ICC/IF,IHC,IP。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-EGFR Antibody (9H356) is a Rabbit antibody targeting EGFR. Anti-EGFR Antibody (9H356) can be used in WB,ICC/IF,IHC,IP.
别名PIG61, NISBD2, mENA, LEGFR, HER1, ERBB1, ERBB, EGFR, EC 2.7.10.1, EC 2.7.10
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of EGFR on different cell lysates using anti-EGFR at 1/500 dilution. Positive control: Line 1: Hela, Line 2: A431, Line 3: HUVEC.
2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-EGFR antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-EGFR antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-EGFR antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-EGFR antibody. Counter stained with hematoxylin.
6. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-EGFR antibody. Counter stained with hematoxylin.
7. ICC staining EGFR in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
8. ICC staining EGFR in A431 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
9. ICC staining EGFR in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC/IF
IHC
IP
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200; IP: 1:10-50
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Exons in the EGFR gene product are frequently either deleted or duplicated to produce deletion mutants (DM) or tandem duplication mutants (TDM), respectively, which are detected at various molecular weights. EGFR binds several ligands, including epidermal growth factor (EGF), transforming growth factor α (TGFα), Amphiregulin and heparin binding-EGF (HB-EGF). Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P00533
化学信息
分子量Theoretical: 134 (Observed: 150) kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

PIG-61PIG 61NISBD-2NISBD 2HER-1HER 1ERBB-1ERBB 1

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