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Anti-CD82 Antibody (3E288)
还可以产品编号 TMAY-02304
Anti-CD82 Antibody (3E288) 是一种 Mouse 抗体，靶向 CD82。Anti-CD82 Antibody (3E288) 可用于 IHC-P。
Anti-CD82 Antibody (3E288)
Anti-CD82 Antibody (3E288)
还可以产品编号 TMAY-02304
Anti-CD82 Antibody (3E288) 是一种 Mouse 抗体，靶向 CD82。Anti-CD82 Antibody (3E288) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD82 Antibody (3E288) is a Mouse antibody targeting CD82. Anti-CD82 Antibody (3E288) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 3E288 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human CD82 in human tonsil with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD82 / KAI-1 (rh CD82 / KAI-1; TMPY-02030; P27701-1; Gly111-Leu228). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent studies suggest that complex mechanisms underlie CD82 loss of function, including altered transcriptional regulation, splice variant production and post-translational protein modifications, and indicate a central role for CD82 in controlling metastasis as a 'molecular facilitator'. The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFkappaB, p53, and beta-catenin. A loss of KAI1 expression is also associated with the advanced stages of many human malignancies and results in the acquisition of invasive and metastatic capabilities by tumour cells. Thus, KAI1/CD82 is regarded as a wide-spectrum tumor metastasis suppressor. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD82 / KAI-1 protein (TMPY-02030) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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