Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OTX008 (PTX008) 是半乳糖凝集素 1 选择性抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 668 | 现货 | ||
5 mg | ¥ 1,390 | 现货 | ||
10 mg | ¥ 2,110 | 现货 | ||
25 mg | ¥ 3,570 | 现货 | ||
50 mg | ¥ 5,170 | 现货 | ||
100 mg | ¥ 7,290 | 现货 | ||
500 mg | ¥ 14,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,190 | 现货 |
产品描述 | OTX008 (PTX008) is a selective galectin-1 inhibitor. |
体外活性 | OTX008 inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways in SQ20B and A2780-1A9 cells and induces G2/M cell cycle arrest through CDK1. OTX008 increases the anti-proliferative effects of Semaphorin-3A (Sema3A) in SQ20B cells and reverses invasion induced by exogenous Gal1. Growth inhibitory concentrations (GI50) of OTX008 range from 3 to 500 μM in a large panel of human solid tumor cell lines. A significant correlation between OTX008 GI50 values and Gal1 mRNA (LGALS1) and protein expression levels in the panel of cancer cells is observed. OTX008 affects endothelial cell proliferation, motility, invasiveness, and cord formation. Tumor cell proliferation is also inhibited, with differences in sensitivity among cell lines (IC50 from 1 to 190 μM)[1][2]. |
体内活性 | OTX008 treatment is associated with the down-regulation of Gal1 and Ki67 in treated tumors, as well as decreased microvessel density and VEGFR2 expression. OTX008 inhibits the growth of A2780-1A9 xenografts. Combination studies display OTX008 synergy with several cytotoxic and targeted therapies, principally when OTX008 is administered first[1]. |
别名 | Calixarene 0118, PTX008 |
分子量 | 937.18 |
分子式 | C52H72N8O8 |
CAS No. | 286936-40-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (10.67 mM), sonification is recommended.
Ethanol: 33.33 mg/mL (35.56 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 1.067 mL | 5.3352 mL | 10.6703 mL | 26.6758 mL |
5 mM | 0.2134 mL | 1.067 mL | 2.1341 mL | 5.3352 mL | |
10 mM | 0.1067 mL | 0.5335 mL | 1.067 mL | 2.6676 mL | |
Ethanol | 20 mM | 0.0534 mL | 0.2668 mL | 0.5335 mL | 1.3338 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
OTX008 286936-40-1 Immunology/Inflammation Galectin OTX 008 OTX-008 Calixarene 0118 PTX-008 PTX008 Calixarene0118 inhibit Calixarene-0118 PTX 008 Inhibitor inhibitor