store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isosilybin B 是一种从水飞蓟中提取的黄酮木脂素,具有抗前列腺癌 (PCA) 活性,对癌细胞增殖有抑制作用,促使 G1 期阻滞和凋亡。Isosilybin B 诱导雄激素受体降解。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,390 | 现货 | ||
5 mg | ¥ 3,490 | 现货 | ||
10 mg | ¥ 4,980 | 现货 | ||
25 mg | ¥ 7,580 | 现货 | ||
50 mg | ¥ 10,000 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,430 | 现货 |
产品描述 | Isosilybin B is a flavonolignan extracted from silymarin that exhibits anti-prostate cancer (PCA) activity, inhibits cancer cell proliferation, and contributes to G1-phase blockade and apoptosis.Isosilybin B induces degradation of the androgen receptor. |
体外活性 | Isosilybin B also inhibited the microvessel sprouting from mouse dorsal aortas ex vivo, and the VEGF-induced cell proliferation, capillary-like tube formation, and invasiveness of human umbilical vein endothelial cells (HUVEC) in vitro. Further studies in HUVEC showed that these diastereoisomers target cell cycle, apoptosis, and VEGF-induced signaling cascade. Three-dimensional growth assay as well as co-culture invasion and in vitro angiogenesis studies (with HUVEC and DU145 cells) suggested the differential effectiveness of the diastereoisomers toward PCA and endothelial cells.[3] |
体内活性 | Isosilybin B (50 and 100 mg/kg body weight; oral) effectively inhibits the growth of advanced human PCA DU145 xenografts. Immunohistochemical analyses revealed that Isosilybin B inhibit tumor angiogenesis biomarkers (CD31 and nestin) and signaling molecules regulating angiogenesis (VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α±) without adversely affecting the vessel-count in normal tissues (liver, lung, and kidney) of tumor-bearing mice.[3] |
分子量 | 482.44 |
分子式 | C25H22O10 |
CAS No. | 142796-22-3 |
store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Isosilybin B 142796-22-3 Apoptosis Endocrinology/Hormones Androgen Receptor Inhibitor inhibitor inhibit