Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-484954 (A 484954) 是一种高度特异性的真核延伸因子-2 抑制剂,其 IC50值为 280 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 313 | 现货 | ||
2 mg | ¥ 463 | 现货 | ||
5 mg | ¥ 828 | 现货 | ||
10 mg | ¥ 1,490 | 现货 | ||
25 mg | ¥ 3,230 | 现货 | ||
50 mg | ¥ 4,780 | 现货 | ||
100 mg | ¥ 6,830 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 983 | 现货 |
产品描述 | A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor. |
靶点活性 | eEF2:280 nM |
体外活性 | A-484954 is a selective eEF2K inhibitor and little activity against a wide panel of serine/threonine and tyrosine kinases. In the enzymatic assay, the IC50 value of A-484954 is increased as the concentration of ATP increased but unaffected by increasing concentrations of calmodulin [1]. |
体内活性 | Long-term A-484954 treatment inhibits MCT-induced increases PA pressure. Furthermore, A-484954 inhibits MCT-induced NADPH oxidase-1 expression and ROS generation as well as matrix metalloproteinase-2 activation [2]. A484954 causes relaxation in E (+) and E (-) aorta or mesenteric artery precontracted with NA. Pretreatment with L-NAME but not indomethacin or cimetidine partially inhibits the A484954-induced relaxation in mesenteric artery [3]. |
别名 | A 484954 |
分子量 | 289.29 |
分子式 | C13H15N5O3 |
CAS No. | 142557-61-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 20 mg/mL (69.13 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4567 mL | 17.2837 mL | 34.5674 mL | 86.4185 mL |
5 mM | 0.6913 mL | 3.4567 mL | 6.9135 mL | 17.2837 mL | |
10 mM | 0.3457 mL | 1.7284 mL | 3.4567 mL | 8.6418 mL | |
20 mM | 0.1728 mL | 0.8642 mL | 1.7284 mL | 4.3209 mL | |
50 mM | 0.0691 mL | 0.3457 mL | 0.6913 mL | 1.7284 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
A-484954 142557-61-7 Autophagy Microbiology/Virology Neuroscience CaMK Parasite Inhibitor Calmodulin-dependent protein kinases A 484954 A484954 inhibit Calmodulin-dependent kinases inhibitor