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HCN Channel

HCN Channel

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. HCN channels are sometimes referred to as pacemaker channels because they help to generate rhythmic activity within groups of heart and brain cells. HCN channels are activated by membrane hyperpolarization, are permeable to Na+ and K+, and are constitutively open at voltages near the resting membrane potential.[2] HCN channels are encoded by four genes (HCN1, 2, 3, 4) and are widely expressed throughout the heart and the central nervous system.
Cat. No. Product Name CAS No. Purity Chemical Structure
T10813 Cilobradine hydrochloride
西洛雷定盐酸盐
186097-54-1 97.46%
Cilobradine hydrochloride (DK-AH 269) 是一种 HCN 通道阻断剂。
T13387L Zatebradine hydrochloride
扎替雷定盐酸盐
91940-87-3 97%
Zatebradine hydrochloride (UL-FS-49CL) 是一种高效的 、有效的HCN Channel 抑制剂( IC50 :1.96 µM)。 HCN Channel 是一种有效的超极化激活环核苷酸门控通道。 Zatebradine hydrochloride 阻止通过人类 HCN1,HCN2,HC...
T7516 ZD7288
化合物ZD7288
133059-99-1 98%
ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂,可抑制海马突触可塑性。
Cilobradine hydrochloride
T10813
Cilobradine hydrochloride (DK-AH 269) 是一种 HCN 通道阻断剂。
Zatebradine hydrochloride
T13387L
Zatebradine hydrochloride (UL-FS-49CL) 是一种高效的 、有效的HCN Channel 抑制剂( IC50 :1.96 µM)。 HCN Channel 是一种有效的超极化激活环核苷酸门控通道。 Zatebradine hydrochloride 阻止通过人类 HCN1,HCN2,HC...
ZD7288
T7516
ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂,可抑制海马突触可塑性。
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