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HCN Channel

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. HCN channels are sometimes referred to as pacemaker channels because they help to generate rhythmic activity within groups of heart and brain cells. HCN channels are activated by membrane hyperpolarization, are permeable to Na+ and K+, and are constitutively open at voltages near the resting membrane potential.[2] HCN channels are encoded by four genes (HCN1, 2, 3, 4) and are widely expressed throughout the heart and the central nervous system.

Cat. No.	Product Name	CAS No.	Purity
T7516	ZD7288 化合物ZD7288	133059-99-1	98%
T7516	ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂，可抑制海马突触可塑性。
T10813	Cilobradine hydrochloride 西洛雷定盐酸盐	186097-54-1	97.46%
T10813	Cilobradine hydrochloride (DK-AH 269) 是一种 HCN 通道阻断剂。
T13387L	Zatebradine hydrochloride 扎替雷定盐酸盐	91940-87-3	97%
T13387L	Zatebradine hydrochloride (UL-FS-49CL) 是一种高效的、有效的HCN Channel 抑制剂( IC50 ：1.96 µM)。 HCN Channel 是一种有效的超极化激活环核苷酸门控通道。 Zatebradine hydrochloride 阻止通过人类 HCN1，HCN2，HC...