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EBI2/GPR183

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein that in humans is encoded by the GPR183 gene.[5] This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41.[6] This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes.[5]

Cat. No.	Product Name	CAS No.	Purity
T14063	7α,25-Dihydroxycholesterol 7α,25-OHC	64907-22-8
T14063	7α,25-Dihydroxycholesterol 是一种孤儿 GPCR 受体EBI2 (GPR183)的内源性配体和有效选择性激动剂。它对激活 EBI2 有很强的作用 (EC50=140 pM;Kd=450 pM)。它能够作为一种趋化因子，指导 B 细胞、T 细胞和树突状细胞的迁移。
T8234	ML401 化合物ML401	1597489-14-9	100%
T8234	ML401 是EBI2(也称为GPR183)的选择性拮抗剂(IC50:1.03 nM)。它在趋化性分析中显示活性 (IC50:6.24 nM)。它表现出良好的稳定性，且无细胞毒性。可用作化学探针。
T7156	NIBR189 化合物NIBR189	1599432-08-2
T7156	NIBR189是 EBI2（GPR183）小分子拮抗剂(IC50:11 nM)。